The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antibiotic treatment of biofilm infections
Open accessAbstract
Bacterial biofilms are associated with a wide range of infections, from those related to exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such as those occurring in the lungs of cystic fibrosis patients. Biofilms are recalcitrant to antibiotic treatment due to multiple tolerance mechanisms (phenotypic resistance). This causes persistence of biofilm infections in spite of antibiotic exposure which predisposes to antibiotic resistance development (genetic resistance). Understanding the interplay between phenotypic and genetic resistance mechanisms acting on biofilms, as well as appreciating the diversity of environmental conditions of biofilm infections which influence the effect of antibiotics are required in order to optimize the antibiotic treatment of biofilm infections. Here, we review the current knowledge on phenotypic and genetic resistance in biofilms and describe the potential strategies for the antibiotic treatment of biofilm infections. Of note is the optimization of PK/PD parameters in biofilms, high‐dose topical treatments, combined and sequential/alternate therapies or the use antibiotic adjuvants.
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Mermel, L. A., Allon, M., Bouza, E., Craven, D. E., Flynn, P., O'Grady, N. P., Raad, I. I., Rijnders, B. J. A., Sherertz, R. J., & Warren, D. K. (2009) · Clinical Infectious Diseases · doi:10.1086/599376 · Cited by 3,638
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858
Cited by
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Biofilm and wound healing: from bench to bedside
Goswami, A. G., Basu, S., Banerjee, T., & Shukla, V. K. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01121-7 · Cited by 178
Strategies for combating antibiotic resistance in bacterial biofilms
Grooters, K. E., Ku, J. C., Richter, D. M., Krinock, M. J., Minor, A., Li, P., Kim, A., Sawyer, R., & Li, Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1352273 · Cited by 156
Cepas, V., López, Y., Gabasa, Y., Martins, C. B., Ferreira, J. D., Correia, M. J., Santos, L. M. A., Oliveira, F., Ramos, V., Reis, M., et al. (2019) · Antibiotics · doi:10.3390/antibiotics8020077 · Cited by 48
Metadata
- Authors
- Ciofu, O., Rojo‐Molinero, E., Macià, M. D., & Oliver, A.
- Venue
- APMIS
- Publisher
- Wiley
- Published
- 2017-04
- Volume
- 125
- Issue
- 4
- Pages
- 304-319
- ISSN
- 0903-4641 (ISSN-L)
- 1600-0463
- OpenAlex
- W2606104114
- Cited by
- 422
- References
- 2
- FWCI
- 12.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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