The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Review article: the human intestinal virome in health and disease
Open accessAbstract
Summary: Background: The human virome consists of animal‐cell viruses causing transient infections, bacteriophage (phage) predators of bacteria and archaea, endogenous retroviruses and viruses causing persistent and latent infections. High‐throughput, inexpensive, sensitive sequencing methods and metagenomics now make it possible to study the contribution dsDNA, ssDNA and RNA virus‐like particles make to the human virome, and in particular the intestinal virome. Aim: To review and evaluate the pioneering studies that have attempted to characterise the human virome and generated an increased interest in understanding how the intestinal virome might contribute to maintaining health, and the pathogenesis of chronic diseases. Methods: Relevant virome‐related articles were selected for review following extensive language‐ and date‐unrestricted, electronic searches of the literature. Results: The human intestinal virome is personalised and stable, and dominated by phages. It develops soon after birth in parallel with prokaryotic communities of the microbiota, becoming established during the first few years of life. By infecting specific populations of bacteria, phages can alter microbiota structure by killing host cells or altering their phenotype, enabling phages to contribute to maintaining intestinal homeostasis or microbial imbalance (dysbiosis), and the development of chronic infectious and autoimmune diseases including HIV infection and Crohn's disease, respectively. Conclusions: Our understanding of the intestinal virome is fragmented and requires standardised methods for virus isolation and sequencing to provide a more complete picture of the virome, which is key to explaining the basis of virome‐disease associations, and how enteric viruses can contribute to disease aetiologies and be rationalised as targets for interventions.
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Citations
Cites
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The human gut virome: inter-individual variation and dynamic response to diet
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“The protective effects of the virome may explain recent findings with respect to treatment of patients with Clostridium difficile infections with sterile faecal filtrates: based on the published protocol, the faecal filtrates used in the study are likely to have contained phages in addition to the “bacterial debris, p…”
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Cited by
Bacteriophages of the Human Gut: The “Known Unknown” of the Microbiome
Shkoporov, A. N., & Hill, C. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.01.017 · Cited by 767
Sorbara, M. T., & Pamer, E. G. (2019) · Mucosal Immunology · doi:10.1038/s41385-018-0053-0 · Cited by 320
Cytokine Tuning of Intestinal Epithelial Function
Andrews, C., McLean, M. H., & Durum, S. K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01270 · Cited by 319
Gut Microbiota beyond Bacteria—Mycobiome, Virome, Archaeome, and Eukaryotic Parasites in IBD
Matijašić, M., Meštrović, T., Čipčić Paljetak, H., Perić, M., Barešić, A., & Verbanac, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082668 · Cited by 284
Bacteriophages in Natural and Artificial Environments
Batinovic, S., Wassef, F., Knowler, S. A., Rice, D. T. F., Stanton, C. R., Rose, J., Tucci, J., Nittami, T., Vinh, A., Drummond, G. R., et al. (2019) · Pathogens · doi:10.3390/pathogens8030100 · Cited by 253
Paediatric functional abdominal pain disorders
Thapar, N., Benninga, M. A., Crowell, M. D., Di Lorenzo, C., Mack, I., Nurko, S., Saps, M., Shulman, R. J., Szajewska, H., van Tilburg, M. A. L., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00222-5 · Cited by 221
Immunogenicity of bacteriophages
Champagne-Jorgensen, K., Luong, T., Darby, T., & Roach, D. R. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.04.008 · Cited by 115
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Buchynskyi, M., Kamyshna, I., Halabitska, I., Petakh, P., Kunduzova, O., Oksenych, V., & Kamyshnyi, O. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1577724 · Cited by 30
Agolino, G., Cristofolini, M., Vaccalluzzo, A., Tagliazucchi, D., Cattivelli, A., Pino, A., Caggia, C., Solieri, L., & Randazzo, C. L. (2025) · Biomolecules · doi:10.3390/biom15010086 · Cited by 19
Metadata
- Authors
- Carding, S. R., Davis, N., & Hoyles, L.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2017-09-04
- Volume
- 46
- Issue
- 9
- Pages
- 800-815
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2751684444
- Cited by
- 247
- References
- 10
- FWCI
- 17.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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