CoChat
Sign Up
Cited by 25Abdominal vascular conditions and treatmentsGastrointestinal motility and disordersGastrointestinal disorders and treatments

Review article: the pharmacological causes of colon ischaemia

Open access
Vodusek, Ziga, Feuerstadt, Paul, Brandt, Lawrence J.·2019·Alimentary Pharmacology & Therapeutics
DOI 10.1111/apt.15052
Open this paper in CoChat — free accountOpen PDF

Abstract

Summary: Background: Colon ischaemia is the most common ischaemic disorder of the gastrointestinal system, can affect any segment of the colon, and may present with a range of symptoms. Diagnosis can be challenging due to symptom overlap with other conditions, varied aetiology, and often rapid and self‐resolving course. Aim: To review comprehensively the literature regarding the pharmacological aetiologies of colonic ischaemia to enhance the understanding of the various mechanisms of disease, presentations, distribution, and outcomes. Methods: A PubMed search for “colon ischaemia” and “ischaemic colitis” alone as well as in combination with various known pharmacologic causes was performed. Only the highest quality and relevant literature was included in this review. The quality of the literature for each association was rated by the authors and a consensus was made when discrepancies were encountered. Only associations that were deemed “moderate” or “strong” were included. Results: The literature considering pharmacologically associated colonic ischaemia is diverse, lacks codification and is characterised by numerous case reports and case series. Constipation‐inducing drugs, digoxin, hormonal therapies, illicit drugs, immunomodulators, laxatives, and NSAIDs were strongly associated with colonic ischaemia. Antimicrobials, appetite suppressants, chemotherapies, decongestants, diuretics, ergot alkaloids, serotonin agents, statins, and vasopressor agents were moderately associated. Conclusions: Patients presenting with abdominal pain, diarrhoea, or bloody stool need to be evaluated for the possibility of this condition and treated accordingly. Timely diagnosis is necessary to improve patient outcomes. This review aims to increase awareness among clinicians regarding the presentation of pharmacologically induced colonic ischaemia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/apt.15052

Cites

158 of 158 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Iatrogenic intestinal ischemia can occur post-surgically, due to dislodgement of intravascular devices, and secondary to use of certain medications.

    “Iatrogenic intestinal ischemia can occur post-surgically (abdominal aortic aneurysm surgery, colectomy, bypass surgery), due to dislodgement of intravascular devices, and secondary to use of certain medications–estrogen, digoxin, danazol, alosetron, pseudo ephedrine, vasopressin, Gold, psychotropic drugs, sumatriptan, serotoninergic agonists and anatagonists immunomodulators, laxatives and non-st”

    From Ischemic bowel disease in 2021. (2021) · cites this paper as [7]

    Section 6 (Summary of Treatment) states that medication use can cause colon ischaemia, and section 5.9 (Vasopressor agents) describes risk in patients receiving vasopressin after cardiopulmonary bypass. The review does not substantiate ischaemia caused by dislodged intravascular devices or the broader list of post-surgical causes in the citing sentence. Page numbers were not supplied in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Part of this paper’s reference list could not be split into single entries.

Flagged first, then by citations

Research works printed but not linked: 4

  1. Saez Gonzalez E, Diaz Jaime FC, Blazquez Martinez MT, et al. Olan- zapine-induced ischemic colitis. Rev Esp Enferm Dig. 2016;108:507- 509.
  2. Bourhis F, Riard P, Danel V, et al. Digitalis poisoning with severe ischemic colitis: a favorable course after treatment with specific antibodies. Gastroenterol Clin Biol. 1990;14:95.
  3. Boza C, Dagnino B, Garrido AM, et al. Ischemic colitis induced by cocaine. Clinical case. Rev Med Chil. 2002;130:667-670.
  4. Holubar SD, Hassinger JP, Dozois EJ, et al. Methamphetamine coli- tis: a rare case of ischemic colitis in a young patient. Arch Surg. 2009;144:780-782.

Cited by

Sorted by citations

Related

Authors
Vodusek, Z., Feuerstadt, P., & Brandt, L. J.
Affiliations
  • Quinnipiac University (US)
  • Yale University (US)
  • Albert Einstein College of Medicine (US)
Corresponding author
Feuerstadt, Paul
ORCID
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2018-11-22
Volume
49
Issue
1
Pages
51-63
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/apt.15052
OpenAlex
W2901562649
Cited by
25
References
158
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 6
FWCI
0.83
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Alimentary Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Seres Therapeutics
Topics
  • Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Gastrointestinal disorders and treatments
Keywords
ischemic colitis, drug-induced colitis, nonsteroidal anti-inflammatory drugs, laxatives, digoxin, hormone therapy, immunomodulators, illicit drugs, statins, vasopressors, ergot alkaloids, antimicrobial agents, appetite suppressants, decongestants, diuretics, hematochezia, abdominal pain, diarrhea
MeSH terms
Anti-Inflammatory Agents, Non-Steroidal, Colon, Constipation, Humans, Abdominal Pain, Colitis, Ischemic, Laxatives

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review