Trials and tribulations of skin iontophoresis in therapeutics
Open accessAbstract
Iontophoresis is a method of non‐invasive transdermal drug delivery based on the transfer of charged molecules using a low‐intensity electric current. Both local and systemic administration are possible; however, the skin pharmacokinetics of iontophoretically delivered drugs is complex and difficult to anticipate. The unquestionable theoretical advantages of the technique make it attractive in several potential applications. After a brief review of the factors influencing iontophoresis, we detail the current applications of iontophoresis in therapeutics and the main potential applications under investigation, including systemic and topical drugs and focusing on the treatment of scleroderma‐related ulcerations. Finally, we address the issue of safety, which could be a limitation to the routine clinical use of iontophoresis.
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There remains a need to ensure that the administered current intensity does not cause cathodal vasodilation or erythema, leading to discomfort to the athlete.
“However, there remains a need to ensure that the administered current intensity does not cause cathodal vasodilation or erythema, leading to discomfort to the athlete.22”
From Wearable sensors for monitoring the physiological and biochemical profile of the athlete (2019) · cites this paper as [22]
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Wearable sensors for monitoring the physiological and biochemical profile of the athlete
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- Authors
- Roustit, M., Blaise, S., & Cracowski, J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Roustit, Matthieu
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2013-12-20
- Volume
- 77
- Issue
- 1
- Pages
- 63-71
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- PMC
- PMC3895348
- OpenAlex
- W1585344386
- Cited by
- 136
- References
- 71
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 13 · 2023: 14 · 2022: 19 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 7 · 2015: 7 · 2014: 3
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Clinical Pharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- iontophoresis, transdermal drug delivery, skin pharmacokinetics, electric current, systemic drug administration, topical administration, non-invasive drug delivery
- MeSH terms
- Administration, Cutaneous, Analgesics, Anesthetics, Local, Pharmaceutical Preparations, Humans, Iontophoresis, Models, Biological, Scleroderma, Localized, Skin Absorption, Skin Ulcer, Vasoconstrictor Agents, Vasodilator Agents, Drug Delivery Systems
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