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Cited by 271

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Adverse reactions to snake antivenom, and their prevention and treatment

Open access
de Silva, H. Asita, Ryan, Nicole M., de Silva, H. Janaka·2016·British Journal of Clinical Pharmacology

Abstract

Antivenom is the mainstay of treatment of snakebite envenoming. However, adverse reactions to snake antivenom that is available are common in many parts of the world where snakebite is prevalent. Both acute (anaphylactic or pyrogenic) and delayed (serum sickness type) reactions occur. Acute reactions are usually mild but severe systemic anaphylaxis may develop, often within an hour or so of exposure to antivenom. Serum sickness after antivenom has a delayed onset between 5 and 14 days after its administration. Ultimately, the prevention reactions will depend mainly on improving the quality of antivenom. Until these overdue improvements take place, doctors will have to depend on pharmacological prophylaxis, where the search for the best prophylactic agent is still on‐going, as well as careful observation of patients receiving antivenom in preparation for prompt management of acute as well as delayed reactions when they occur.

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Registry

Crossref · 10.1111/bcp.12739

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Metadata

Authors
de Silva, H. A., Ryan, N. M., & de Silva, H. J.
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
2015-09-16
Volume
81
Issue
3
Pages
446-452
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
OpenAlex
W1950381803
Cited by
271
References
30
FWCI
7.81
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Adverse reactions to snake antivenom, and their prevention and treatment. https://app.cochat.ai/papers/10.1111/bcp.12739
The paper
de Silva, H. A., Ryan, N. M., & de Silva, H. J. (2016). Adverse reactions to snake antivenom, and their prevention and treatment. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.12739

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.