The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Milk‐derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis
Open accessAbstract
Bioactive peptides derived from milk proteins are food components that, in addition to their nutritional value, retain many biological properties and have therapeutic effects in several health disorders, including cardiovascular disease. Amongst these, atherosclerosis is the underlying cause of heart attack and strokes. It is a progressive dyslipidaemic and inflammatory disease where accumulation of oxidized lipids and inflammatory cells leads to the formation of an atherosclerotic plaque in the vessel wall. Milk‐derived bioactive peptides can be released during gastrointestinal digestion, food processing or by enzymatic and bacterial fermentation and are considered to promote diverse beneficial effects such as lipid lowering, antihypertensive, immnomodulating, anti‐inflammatory and antithrombotic effects. In this review, an overview of the diverse biological effects of these compounds is given, particularly focusing on their beneficial properties on cardiovascular disease and proposing novel mechanisms of action responsible for their bioactivity. Attempts to prevent cardiovascular diseases target modifications of several risk factors such as high blood pressure, obesity, high blood concentrations of lipids or insulin resistance. Milk‐derived bioactive peptides are a source of health‐enhancing components and the potential health benefit of these compounds has a growing commercial potential. Consequently, they have been incorporated as ingredients in functional foods, as dietary supplements and as pharmaceuticals to promote health and reduce risk of chronic diseases.
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Cites
Chinetti, G., Fruchart, J.-C., & Staels, B. (2000) · Inflammation Research · doi:10.1007/s000110050622 · Cited by 954
Hernández-Ledesma, B., Dávalos, A., Bartolomé, B., & Amigo, L. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf048626m · Cited by 634
Grundy, S. M., Balady, G. J., Criqui, M. H., Fletcher, G., Greenland, P., Hiratzka, L. F., Houston-Miller, N., Kris-Etherton, P., Krumholz, H. M., LaRosa, J., et al. (1998) · Circulation · doi:10.1161/01.cir.97.18.1876 · Cited by 609
Yamamoto, N., Akino, A., & Takano, T. (1994) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(94)77026-0 · Cited by 418
Casein peptide release and passage to the blood in humans during digestion of milk or yogurt.
Chabance, B., Marteau, P., Rambaud, J. C., Migliore-Samour, D., Boynard, M., Perrotin, P., Guillet, R., Jollès, P., & Fiat, A. M. (1998) · Biochimie · doi:10.1016/s0300-9084(98)80022-9 · Cited by 324
Regulation of cytokine release from mononuclear cells by the iron- binding protein lactoferrin
Crouch, S., Slater, K., & Fletcher, J. (1992) · Blood · doi:10.1182/blood.v80.1.235.235 · Cited by 294
Calbet, J. A. L., & Holst, J. J. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0448-4 · Cited by 288
Kappacin, a novel antibacterial peptide from bovine milk.
Malkoski, M., Dashper, S. G., O'Brien-Simpson, N. M., Talbo, G. H., Macris, M., Cross, K. J., & Reynolds, E. C. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.8.2309-2315.2001 · Cited by 216
Kayser, H., & Meisel, H. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00207-4 · Cited by 203
Sheep κ-casein peptides inhibit platelet aggregation.
Qian, Z.-Y., Jollès, P., Migliore-Samour, D., Schoentgen, F., & Fiat, A.-M. (1995) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(95)00047-f · Cited by 63
Cited by
Cicero, A. F. G., Fogacci, F., & Colletti, A. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13608 · Cited by 317
Zhang, X., Chen, X., Xu, Y., Yang, J., Du, L., Li, K., & Zhou, Y. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-020-00527-y · Cited by 195
Dairy bioactive proteins and peptides: a narrative review
Auestad, N., & Layman, D. K. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab097 · Cited by 153
Bioactive peptides from milk: Animal determinants and their implications in human health
Vargas-Bello-Pérez, E., Márquez-Hernández, R. I., & Hernández-Castellano, L. E. (2019) · Journal of Dairy Research · doi:10.1017/s0022029919000384 · Cited by 97
Metadata
- Authors
- Marcone, S., Belton, O., & Fitzgerald, D. J.
- Venue
- British Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 2016-06-17
- Volume
- 83
- Issue
- 1
- Pages
- 152-162
- ISSN
- 0306-5251 (ISSN-L)
- 1365-2125
- OpenAlex
- W2346688577
- Cited by
- 234
- References
- 11
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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