Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790
Open accessAbstract
Peptides derived from alpha s1- and beta-caseins by the Lactobacillus helveticus CP790 proteinase were investigated for their inhibitory activities against angiotensin I-converting enzyme. The antihypertensive effect of casein hydrolysates in strain SHR spontaneously hypertensive rats was also investigated. Both alpha s1- and beta-casein hydrolysates inhibited this enzyme. Some of these peptides showed enzyme inhibitory activity, and one of them from beta-casein inhibited the enzyme greatly; the concentration of an angiotensin I-converting enzyme inhibitor needed to inhibit 50% of the enzyme activity was 4 microM. The hydrolysate of casein demonstrated antihypertensive activity in spontaneously hypertensive rats at an orally administered dosage of 15 mg/kg of body weight. MILK fermented with L. helveticus CP790, containing about .3% peptides, also showed antihypertensive activity in SHR rats with 5 ml/kg of body weight (15 mg of peptide/kg); however, the milk fermented with L. helveticus CP791, a variant defective for proteinase activity, did not show this activity. Results suggested that the peptides liberated from casein by the proteinase in the culture medium showed antihypertensive effect in SHR rats.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some strains of L. helveticus such as CP790, CP53, and PR4 are able to hydrolyze both αs1- and β-casein.
“Some strains of L. helveticus such as CP790 (Yamamoto et al., 1994), CP53 (Ono et al., 1997), and PR4 (Di Cagno et al., 2006) are able to hydrolyze both αs1- and β-casein.”
From Lactobacillus helveticus: the proteolytic system (2013) · cites this paper as Yamamoto et al., 1994
Cites
Church, F., Swaisgood, H. E., Porter, D. H., & Catignani, G. L. (1983) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(83)81926-2 · Cited by 1,551 · see citing works
Cushman, D. W., Cheung, H. S., Sabo, E. F., & Ondetti, M. A. (1977) · Biochemistry · doi:10.1021/bi00644a014 · Cited by 893 · see citing works
Angiotensin I converting enzyme.
Erdös, E. G. (1975) · Circulation Research · doi:10.1161/01.res.36.2.247 · Cited by 555 · see citing works
Ondetti, M. A., Williams, N. J., Sabo, E. F., PLUSCEC, J., Weaver, E. R., & Kocy, O. (1971) · Biochemistry · doi:10.1021/bi00798a004 · Cited by 521 · see citing works
Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom
Ferreira, S. H., Bartelt, D. C., & Greene, L. J. (1970) · Biochemistry · doi:10.1021/bi00815a005 · Cited by 515 · see citing works
Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom
J.P. (1971) · Toxicon · doi:10.1016/0041-0101(71)90098-5 · Cited by 480 · see citing works
Maruyama, S., Nakagomi, K., Tomizuka, N., & Suzuki, H. (1985) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1985.10866901 · Cited by 201 · see citing works
(1981) · Cited by 154 · see citing works
Antihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats
Karaki, H., Kunio, D., SUGANO, S., Hideyo, U., Ryuji, S., Umeji, M., & Takemoto, S. (1990) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0742-8413(90)90023-3 · Cited by 135 · see citing works
Maruyama, S., Mitachi, H., Tanaka, H., Tomizuka, N., & Suzuki, H. (1987) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.51.1581 · Cited by 126 · see citing works
Casein utilization by lactococci
Smid, E. J., Poolman, B., & Konings, W. N. (1991) · Applied and Environmental Microbiology · doi:10.1128/aem.57.9.2447-2452.1991 · Cited by 119 · see citing works
Angiotensin I-Converting Enzyme Inhibitory Activity of the C-Terminal Hexapeptide of αs1-Casein
Maruyama, S., Mitachi, H., Awaya, J., Kurono, M., Tomizuka, N., & Suzuki, H. (1987) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1987.10868415 · Cited by 115 · see citing works
Khalid, N. M., & Marth, E. H. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.2.381-388.1990 · Cited by 114 · see citing works
Meyer, J., & Jordi, R. (1987) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(87)80068-1 · Cited by 104 · see citing works
Yamamoto, N., Akino, A., & Takano, T. (1993) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124247 · Cited by 91 · see citing works
Self-citationMaruyama, S., Mitachi, H., Awaya, J., Kurono, M., Tomizuka, N., & Suzuki, H. (1987) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.51.2557 · Cited by 88 · see citing works
Specificity of a cell wall proteinase from Streptococcus lactis NCDO763 towards bovine β-casein
Monnet, V., Bars, D. L., & Gripon, J. C. (1986) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1986.tb01681.x · Cited by 71 · see citing works
Maruyama, S., Miyoshi, S., Kaneko, T., & Tanaka, H. (1989) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.53.1077 · Cited by 64 · see citing works
Properties and specificity of a cell-wall proteinase from <i>Lactobacillus helveticus</i>
ZEVACO, C., & GRIPON, J.-C. (1988) · Le Lait · doi:10.1051/lait:1988425 · Cited by 60 · see citing works
Purification and Characterization of an Antihypertensive Compound fromLactohacillus casei
Sawada, H., Furushiro, M., Hirai, K., Motoike, M., Watanabe, T., & Yokokura, T. (1990) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1990.10870492 · Cited by 55 · see citing works
Maruyama, S., Mitachi, H., Tanaka, H., Tomizuka, N., & Suzuki, H. (1987) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1987.10868244 · Cited by 48 · see citing works
Purification and Characterization of an Aminopeptidase from Lactobacillus helveticus LHE-511
Miyakawa, H., Kobayashi, S., Shimamura, S., & TOMITA, M. (1992) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(92)77734-0 · Cited by 46 · see citing works
Purification and characterization of an antihypertensive compound from Lactobacillus casei.
Sawada, H., Furushiro, M., HIRAI, K., Motoike, M., Watanabe, T., & Yokokura, T. (1990) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.54.3211 · Cited by 38 · see citing works
Furushiro, M., Sawada, H., Hirai, K., Motoike, M., Sansawa, H., Kobayashi, S., Watanuki, M., & Yokokura, T. (1990) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.54.2193 · Cited by 34 · see citing works
Monnet, V., Bars, D. L., Neviani, E., Neviani, E., & Gripon, J. C. (1987) · Le Lait · doi:10.1051/lait:198713 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Bioactive peptides: Production and functionality
Korhonen, H. J. T., & Pihlanto, A. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.10.012 · Cited by 1,765 · see citing works
Purification and Characterization of Angiotensin I-Converting Enzyme Inhibitors from Sour Milk
Nakamura, Y., Yamamoto, N., Sakai, K., Ōkubo, A., Yamazaki, S., & Takano, T. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76689-9 · Cited by 838 · see citing works
Self-citationBioactive milk peptides: a prospectus.
Clare, D. A., & Swaisgood, H. E. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)74983-6 · Cited by 718 · see citing works
Bioactive peptides derived from bovine whey proteins
Pihlanto-Leppälä, A. (2000) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(01)00003-6 · Cited by 606 · see citing works
Bioactive peptides and proteins from foods: indication for health effects.
Möller, N. P., Scholz-Ahrens, K. E., Roos, N., & Schrezenmeir, J. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0710-2 · Cited by 595 · see citing works
Wu, J., Aluko, R. E., & Nakai, S. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051263l · Cited by 562 · see citing works
Nakamura, Y., Yamamoto, N., Sakai, K., & Takano, T. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76745-5 · Cited by 556 · see citing works
Self-citationLi, G., Le, G., Shi, Y., & Shrestha, S. (2004) · Nutrition Research · doi:10.1016/j.nutres.2003.10.014 · Cited by 554 · see citing works
Antihypertensive peptides: Production, bioavailability and incorporation into foods
Hernández‐Ledesma, B., Contreras, M. D. M., & Recio, I. (2010) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2010.11.001 · Cited by 510 · see citing works
A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects
Hata, Y., Yamamoto, M., Ohni, M., Nakajima, K., Nakamura, Y., & Takano, T. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.767 · Cited by 508 · see citing works
Self-citationCompositional, technological and nutritional aspects of dromedary camel milk
haj, O. A. A., & Alkanhal, H. A. (2010) · International Dairy Journal · doi:10.1016/j.idairyj.2010.04.003 · Cited by 487 · see citing works
Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme
Fitzgerald, R. J., & Meisel, H. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500002221 · Cited by 472 · see citing works
Caseins as source of bioactive peptides
Silva, S. V., & Malcata, F. X. (2004) · International Dairy Journal · doi:10.1016/j.idairyj.2004.04.009 · Cited by 439 · see citing works
Beyond gut feelings: how the gut microbiota regulates blood pressure
Marques, F. Z., Mackay, C. R., & Kaye, D. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.120 · Cited by 400 · see citing works
Maeno, M., Yamamoto, N., & Takano, T. (1996) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(96)76487-1 · Cited by 392 · see citing works
Self-citationLópez‐Fandiño, R., Otte, J., & Camp, J. V. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2006.06.004 · Cited by 385 · see citing works
Lee, S., Qian, Z., & Kim, S. (2009) · Food Chemistry · doi:10.1016/j.foodchem.2009.04.086 · Cited by 366 · see citing works
Phelan, M., Aherne, A., Fitzgerald, R. J., & O’Brien, N. M. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.06.001 · Cited by 354 · see citing works
Gobbetti, M., Stepaniak, L., De Angelis, M., Corsetti, A., & Di Cagno, R. (2002) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690290825538 · Cited by 344 · see citing works
Wu, J., & Ding, X. (2002) · Food Research International · doi:10.1016/s0963-9969(01)00131-4 · Cited by 344 · see citing works
Gobbetti, M., Ferranti, P., Smacchi, E., Goffredi, F., & Addeo, F. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.9.3898-3904.2000 · Cited by 343 · see citing works
Abubakar, A., Saito, T., Kitazawa, H., Kawai, Y., & Itoh, T. (1998) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(98)75878-3 · Cited by 330 · see citing works
Bioactive peptides of animal origin: a review
Bhat, Z. F., Kumar, S., & Bhat, H. F. (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-015-1731-5 · Cited by 308 · see citing works
Meisel, H., & Bockelmann, W. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002063805780 · Cited by 284 · see citing works
Foltz, M., Meynen, E., Bianco, V., van Platerink, C. J., Koning, T. M. G., & Kloek, J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.4.953 · Cited by 271 · see citing works
Minervini, F., Algaron, F., Rizzello, C. G., Fox, P. F., Monnet, V., & Gobbetti, M. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.9.5297-5305.2003 · Cited by 270 · see citing works
Angiotensin I-converting-enzyme-inhibitory and antimicrobial bioactive peptides.
Gobbetti, M., Minervini, F., & Rizzello, C. G. (2004) · International Journal of Dairy Technology · doi:10.1111/j.1471-0307.2004.00139.x · Cited by 268 · see citing works
Yamamoto, N., Maeno, M., & Takano, T. (1999) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(99)75364-6 · Cited by 266 · see citing works
Self-citationHernández‐Ledesma, B., Quirós, A., Amigo, L., & Recio, I. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.12.012 · Cited by 258 · see citing works
Mullally, M. M., Meisel, H., & Fitzgerald, R. J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01503-7 · Cited by 253 · see citing works
Casein-Derived Antimicrobial Peptides Generated by Lactobacillus acidophilus DPC6026
Hayes, M., Ross, R. P., Fitzgerald, G. F., Hill, C., & Stanton, C. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.3.2260-2264.2006 · Cited by 250 · see citing works
Identification of antioxidant and ACE‐inhibitory peptides in fermented milk
Hernández‐Ledesma, B., Miralles, B., Amigo, L., Ramos, M., & Recio, I. (2005) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2063 · Cited by 248 · see citing works
ACE-inhibitory activity of probiotic yoghurt
Donkor, O. N., Henriksson, A., Singh, T. K., Vasiljevic, T., & Shah, N. P. (2007) · International Dairy Journal · doi:10.1016/j.idairyj.2007.02.009 · Cited by 247 · see citing works
Novel casein-derived peptides with antihypertensive activity
Contreras, M. D. M., Carrón, R., Montero, M. J., Ramos, M., & Recio, I. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.05.004 · Cited by 244 · see citing works
Lactobacillus helveticus: the proteolytic system
Griffiths, M. W., & Tellez, A. M. (2013) · Frontiers in Microbiology · doi:10.3389/fmicb.2013.00030 · Cited by 241 · see citing works
“Bioactivity Strain References Antihypertensive CP790 Wakai and Yamamoto, 2012 CP611 CP615 JCM1006 JCM1004 CNRZ32 Kilpi et al., 2007 CM4 Ueno et al., 2004 R211 Leclerc et al., 2002 R389 Leclerc et al., 2002 LMG 11474 Vermeirssen et al., 2003 LBK-16H Seppo et al., 2003 Immunomodulatory 5089 Laffineur et al., 1996 389 Ma…”
BackgroundInfluentialFunctional Microorganisms for Functional Food Quality
Gobbetti, M., Cagno, R. D., & Angelis, M. D. (2010) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.499770 · Cited by 241 · see citing works
Angiotensin-Converting Enzyme Inhibitory Activity of Peptides Derived from Caprine Kefir
Quirós, A., Hernández-Ledesma, B., Ramos, M., Amigo, L., & Recio, I. (2005) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(05)73032-0 · Cited by 237 · see citing works
Marcone, S., Belton, O., & Fitzgerald, D. J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13002 · Cited by 235 · see citing works
Peptides From Milk Proteins and Their Properties
Kilara, A., & Panyam, D. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390251138 · Cited by 230 · see citing works
Korhonen, H. T., & Pihlanto, A. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780363112 · Cited by 229 · see citing works
Proteolytic enzymes of lactic acid bacteria
Law, J., & Haandrikman, A. (1997) · International Dairy Journal · doi:10.1016/0958-6946(95)00073-9 · Cited by 225 · see citing works
Bioactive peptides and proteins
Pihlanto, A., & Korhonen, H. T. (2003) · Advances in food and nutrition research · doi:10.1016/s1043-4526(03)47004-6 · Cited by 220 · see citing works
Arihara, K., Nakashima, Y., Mukai, T., Ishikawa, S., & Itoh, M. (2001) · Meat Science · doi:10.1016/s0309-1740(00)00108-x · Cited by 219 · see citing works
Mullally, M. M., Meisel, H., & Fitzgerald, R. J. (1997) · International Dairy Journal · doi:10.1016/s0958-6946(97)00018-6 · Cited by 216 · see citing works
Saâdi, S., Saari, N., Anwar, F., Hamid, A. A., & Ghazali, H. M. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.12.003 · Cited by 212 · see citing works
LeBlanc, J. G., Matar, C., Valdéz, J. C., LeBlanc, J., & Perdigon, G. (2002) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(02)74360-9 · Cited by 210 · see citing works
Antihypertensive peptides derived from food proteins
Yamamoto, N. (1997) · Biopolymers · doi:10.1002/(sici)1097-0282(1997)43:2 · Cited by 210 · see citing works
Hernández‐Ledesma, B., Amigo, L., Ramos, M., & Recio, I. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf034997b · Cited by 208 · see citing works
Hayes, M., Stanton, C., Fitzgerald, G. F., & Ross, R. P. (2007) · Biotechnology Journal · doi:10.1002/biot.200700045 · Cited by 204 · see citing works
Bioactive peptides in dairy products
Choi, J.-W., Sabikhi, L., Hassan, A. N., & Anand, S. K. (2011) · International Journal of Dairy Technology · doi:10.1111/j.1471-0307.2011.00725.x · Cited by 192 · see citing works
Pihlanto, A., Virtanen, T., & Korhonen, H. J. T. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.07.003 · Cited by 190 · see citing works
Milk Peptides and Blood Pressure1,
Jauhiainen, T., & Korpela, R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.825s · Cited by 186 · see citing works
Ebner, J., Arslan, A. A., Fedorova, M., Hoffmann, R., Küçükçetin, A., & Pischetsrieder, M. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.01.005 · Cited by 183 · see citing works
Meisel, H. (1997) · Livestock Production Science · doi:10.1016/s0301-6226(97)00083-3 · Cited by 183 · see citing works
Antihypertensive and antimicrobial bioactive peptides from milk proteins
., E. M. H., & Chand, R. (2007) · European Food Research and Technology · doi:10.1007/s00217-007-0689-6 · Cited by 182 · see citing works
Otte, J., Shalaby, S. M., Zakora, M., Pripp, A. H., & El‐Shabrawy, S. A. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2006.05.011 · Cited by 181 · see citing works
Papadimitriou, C. S., Vafopoulou-Mastrojiannaki, A., SILVA, S., Gomes, A., Malcata, F. X., & Alichanidis, E. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.04.028 · Cited by 179 · see citing works
Milk and the metabolic syndrome
Pfeuffer, M., & Schrezenmeir, J. (2006) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00265.x · Cited by 173 · see citing works
Pan, D., Cao, J., Guo, H., & Zhao, B. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.07.011 · Cited by 171 · see citing works
Transepithelial Transport of Oligopeptides in the Human Intestinal Cell, Caco-2
Shimizu, M., Tsunogai, M., & Arai, S. (1997) · Peptides · doi:10.1016/s0196-9781(97)00002-8 · Cited by 165 · see citing works
Biological activity of peptides purified from fish skin hydrolysates
Abuine, R., Rathnayake, A. U., & Byun, H. (2019) · Fisheries and aquatic sciences · doi:10.1186/s41240-019-0125-4 · Cited by 165 · see citing works
Biofunctional Properties of Bioactive Peptides of Milk Origin
., E. M. H., Chand, R., & Kapila, S. (2008) · Food Reviews International · doi:10.1080/87559120802458198 · Cited by 161 · see citing works
Peptidomic analysis reveals proteolytic activity of kefir microorganisms on bovine milk proteins
Dallas, D. C., Citerne, F., Tian, T., Silva, V. L. M., Kalanetra, K. M., Frese, S. A., Robinson, R. C., Mills, D. A., & Barile, D. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.10.116 · Cited by 160 · see citing works
Angiotensin‐I‐converting enzyme inhibitory peptides from tryptic hydrolysate of bovine αS2‐casein
Tauzin, J., Miclo, L., & Gaillard, J. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03576-7 · Cited by 157 · see citing works
Antihypertensive Peptides from Milk Proteins
Jäkälä, P., & Vapaatalo, H. (2010) · Pharmaceuticals · doi:10.3390/ph3010251 · Cited by 156 · see citing works
Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men
Mizushima, S.-I. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.03.674 · Cited by 155 · see citing works
Hayes, M., Stanton, C., Slattery, H., O’Sullivan, Ó., Hill, C., Fitzgerald, G. F., & Ross, R. P. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00096-07 · Cited by 154 · see citing works
Gouda, K. G. M., Gowda, L. R., Rao, A. G. A., & Prakash, V. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060264q · Cited by 148 · see citing works
Antihypertensive Peptides Derived from Bovine Casein and Whey Proteins
Saito, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-74087-4_12 · Cited by 147 · see citing works
Rai, A. K., Sanjukta, S., & Jeyaram, K. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1068736 · Cited by 147 · see citing works
Health-Promoting Properties of Lactobacillus helveticus
Taverniti, V., & Guglielmetti, S. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00392 · Cited by 147 · see citing works
The potential role of milk-derived peptides in cardiovascular disease
Phelan, M., & Kerins, D. M. (2011) · Food & Function · doi:10.1039/c1fo10017c · Cited by 146 · see citing works
Amorim, F. G., Coitinho, L. B., Dias, A. T., Friques, A. G. F., Monteiro, B. L., de Rezende, L. C. D., Pereira, T. D. M. C., Campagnaro, B. P., Pauw, E. D., Vasquez, E. C., et al. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.01.010 · Cited by 145 · see citing works
Bioactive peptides in dairy products: synthesis and interaction with proteolytic enzymes
Smacchi, E., & Gobbetti, M. (2000) · Food Microbiology · doi:10.1006/fmic.1999.0302 · Cited by 145 · see citing works
Purification and Identification of antihypertensive peptides in Spanish dry-cured ham
Escudero, E., Mora, L., Fraser, P. D., Aristoy, M., Arihara, K., & Toldrá, F. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.10.019 · Cited by 144 · see citing works
Guo, Y., Pan, D., & Tanokura, M. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.09.041 · Cited by 143 · see citing works
Antihypertensive activity of casein-enriched milk fermented by Lactobacillus helveticus
Leclerc, P.-L., Gauthier, S. F., Bachelard, H., Santuré, M., & Roy, D. (2002) · International Dairy Journal · doi:10.1016/s0958-6946(02)00125-5 · Cited by 143 · see citing works
Tsai, J. S., Lin, Y. S., Pan, B. S., & Chen, T. J. (2006) · Process Biochemistry · doi:10.1016/j.procbio.2005.12.026 · Cited by 142 · see citing works
Robert, M.-C., Razaname, A., Mutter, M., & Juillerat, M. A. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049510t · Cited by 142 · see citing works
Antihypertensive activity of milk fermented by Enterococcus faecalis strains isolated from raw milk
Muguerza, B., Ramos, M., Sánchez, E., Manso-Silván, M. A., Miguel, M., Aleixandre, A., Delgado, M. A., & Recio, I. (2005) · International Dairy Journal · doi:10.1016/j.idairyj.2005.01.001 · Cited by 139 · see citing works
Nielsen, M. S., Martinussen, T., Flambard, B., Sørensen, K. I., & Otte, J. (2008) · International Dairy Journal · doi:10.1016/j.idairyj.2008.10.003 · Cited by 139 · see citing works
Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides
López‐Expósito, I., Quirós, A., Amigo, L., & Recio, I. (2007) · Le Lait · doi:10.1051/lait:2007019 · Cited by 138 · see citing works
Milk Protein Hydrolysates and Bioactive Peptides
Nongonierma, A. B., O’Keeffe, M. B., & Fitzgerald, R. J. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2800-2_15 · Cited by 138 · see citing works
Health-Related Aspects of Milk Proteins.
Davoodi, S. H., Shahbazi, R., Esmaeili, S., Sohrabvandi, S., Mortazavian, A. M., Jazaeri, S., & Taslimi, A. (2016) · PubMed Central · Cited by 135 · see citing works
Byun, H., & Kim, S. (2002) · BMB Reports · doi:10.5483/bmbrep.2002.35.2.239 · Cited by 134 · see citing works
Smacchi, E., & Gobbetti, M. (1998) · Enzyme and Microbial Technology · doi:10.1016/s0141-0229(97)00261-5 · Cited by 134 · see citing works
Muralitharan, R. R., Jama, H. A., Xie, L., Peh, A., Snelson, M., & Marques, F. Z. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14473 · Cited by 131 · see citing works
Moayedi, A. A., Mora, L., Aristoy, M., Safari, M., Hashemi, M., & Toldrá, F. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.01.033 · Cited by 125 · see citing works
Bioactive substances in milk with properties decreasing risk of cardiovascular diseases
Pfeuffer, M., & Schrezenmeir, J. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500002385 · Cited by 125 · see citing works
Broadbent, J. R., Cai, H., Larsen, R. L., Hughes, J. E., Welker, D. L., De Carvalho, V. G., Tompkins, T. A., Ardö, Y., Vogensen, F., De Lorentiis, A., et al. (2011) · Journal of Dairy Science · doi:10.3168/jds.2010-4068 · Cited by 124 · see citing works
Xu, Y., Li, Y., Bao, T., Zheng, X., Chen, W., & Wang, J. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.10.053 · Cited by 123 · see citing works
Nejati, F., Rizzello, C. G., Cagno, R. D., Sheikh‐Zeinoddin, M., Diviccaro, A., Minervini, F., & Gobbetti, M. (2012) · LWT · doi:10.1016/j.lwt.2012.09.017 · Cited by 121 · see citing works
Lassoued, I., Mora, L., Barkia, A., Aristoy, M., Nasri, M., & Toldrá, F. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.06.016 · Cited by 121 · see citing works
Chen, Y., Liu, W., Xue, J., Yang, J., Chen, X., Shao, Y., Kwok, L., Bilige, M., Lai, M., & Zhang, H. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-7962 · Cited by 121 · see citing works
Chen, G., Tsai, J., & Pan, B. S. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2006.07.004 · Cited by 121 · see citing works
Vermeirssen, V., Camp, J. V., Decroos, K., Wijmelbeke, L. V., & Verstraete, W. (2003) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(03)73621-2 · Cited by 121 · see citing works
Tsai, J., Chen, T.-J., Pan, B. S., Gong, S.-D., & Chung, M.-Y. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.06.039 · Cited by 120 · see citing works
Rojas-Ronquillo, R., Cruz-Guerrero, A. E., Flores-Nájera, A., Rodríguez-Serrano, G. M., Gómez‐Ruiz, L., Reyes‐Grajeda, J. P., Jiménez‐Guzmán, J., & García‐Garibay, M. (2012) · International Dairy Journal · doi:10.1016/j.idairyj.2012.05.002 · Cited by 119 · see citing works
Original features of cell-envelope proteinases of Lactobacillus helveticus. A review
Sadat-Mekmene, L., Genay, M., Atlan, D., Lortal, S., & Gagnaire, V. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.01.039 · Cited by 119 · see citing works
Chen, Y., Wang, Z., Chen, X.-T., Liu, Y., Zhang, H., & Sun, T. (2010) · Journal of Dairy Science · doi:10.3168/jds.2009-2672 · Cited by 116 · see citing works
- Authors
- Yamamoto, N., Akino, A., & Takano, T.
- Affiliations
- Calpis Co., Ltd. (Japan) (JP)
- ORCID
- Yamamoto, Naoyuki
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 1994-04
- Volume
- 77
- Issue
- 4
- Pages
- 917-922
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W2165457361
- Cited by
- 418
- References
- 25
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 10 · 2023: 17 · 2022: 12 · 2021: 6 · 2020: 22 · 2019: 16 · 2018: 13 · 2017: 16 · 2016: 20 · 2015: 22 · 2014: 15 · 2013: 12 · 2012: 22
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
- Keywords
- antihypertensive peptides, casein hydrolysate, Lactobacillus helveticus, extracellular protease, angiotensin-converting enzyme inhibition, αs1-casein, β-casein, spontaneously hypertensive rats, fermented milk, bioactive peptides
- MeSH terms
- Amino Acid Sequence, Animals, Caseins, Fermentation, Hydrolysis, Hypertension, Lactobacillus, Male, Milk, Molecular Sequence Data, Peptide Fragments, Endopeptidases, Rats, Inbred SHR, Rats, Inbred WKY, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review