Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins.
Abstract
The in vitro modulation of the proliferation of human peripheral blood lymphocytes of different synthetic peptides derived from milk proteins was investigated. Therefore, proliferation changes were followed up after incorporation of BrdU into the DNA, and the influence on protein biosynthesis was measured using the [3 H]leucine incorporation test. Tyr‐Gly and Tyr‐Gly‐Gly significantly enhanced (maximal 90 and 35%, respectively) the proliferation of PBL. For β‐casomorphin‐7 and β‐casokinin‐10, lymphocyte proliferation was suppressed at lower concentrations, but stimulated at higher concentrations (≥10−7 mol/l). Protein synthesis was stimulated (maxima at 25%) only with Tyr‐Gly and Tyr‐Gly‐Gly. The findings point to a need for further studies on the possible function of peptides derived from milk proteins as orally bioavailable immunopotentiatory compounds.
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Proliferation of human peripheral blood lymphocytes is induced by the k-casein and alpha lactalbumin fragment Tyr-Gly-Gly.
“proliferation of human peripheral blood lymphocytes is induced by the k-casein and alpha lactalbumin fragment Tyr-Gly-Gly (Kayser and Meisel, 1996; Sharma et al., 2011).”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Kayser and Meisel, 1996
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- Authors
- Kayser, H., & Meisel, H.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1996-03-25
- Volume
- 383
- Issue
- 1-2
- Pages
- 18-20
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1999372506
- Cited by
- 203
- References
- 13
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 11 · 2015: 5 · 2014: 11 · 2013: 9 · 2012: 8
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- bovine milk proteins, lymphocyte proliferation, peripheral blood lymphocytes, beta-casomorphin-7, protein synthesis, immunopotentiators, oral bioavailability, immunomodulation
- MeSH terms
- Amino Acid Sequence, Bromodeoxyuridine, Caseins, Cell Division, Concanavalin A, Dipeptides, DNA, Endorphins, Humans, Leucine, Lymphocyte Activation, Lymphocytes, Milk Proteins, Molecular Sequence Data, Oligopeptides, Peptide Fragments
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