The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Development and validation of the International Hidradenitis Suppurativa Severity Score System ( IHS 4), a novel dynamic scoring system to assess HS severity
Open accessAbstract
BACKGROUND: A validated tool for the dynamic severity assessment of hidradenitis suppurativa/acne inversa (HS) is lacking. OBJECTIVES: To develop and validate a novel dynamic scoring system to assess the severity of HS. METHODS: A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Strengths and weaknesses of HS4 were examined by a multicentre prospective study. Multivariate logistic regression, discriminant analysis and receiver operating characteristic curves, as well as examination for correlation (Spearman's rho) and agreement (Cohen's kappa) with existing scores, were engaged to recognize the variables for a new International HS4 (IHS4) that was established by a second Delphi round. RESULTS: Consensus HS4 was based on number of skin lesions, number of skin areas involved and Dermatology Life Quality Index (DLQI), and was evaluated by a sample of 236 patients from 11 centres. Subsequently, a multivariate regression model calculated adjusted odds ratios for several clinical signs. Nodules, abscesses and draining tunnels resulted as the scoring variables. Three candidate scores were presented to the second Delphi round. The resulting IHS4 score is arrived at by the number of nodules (multiplied by 1) plus the number of abscesses (multiplied by 2) plus the number of draining tunnels (multiplied by 4). A total score of 3 or less signifies mild, 4-10 signifies moderate and 11 or higher signifies severe disease. Cohen's kappa was fair (κ = 0·32) compared with Hurley classification, and moderate (κ = 0·49) compared with Expert Opinion. Correlation was good (ρ > 0·6) with Hurley classification, Expert Opinion, Physician's Global Assessment and Modified Sartorius score, and moderate for DLQI (ρ = 0·36). CONCLUSIONS: The novel IHS4 is a validated tool to dynamically assess HS severity and can be used both in real-life and the clinical trials setting.
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Citations
Cites
Comorbidities of hidradenitis suppurativa (acne inversa)
Fimmel, S., & Zouboulis, C. C. (2010) · Dermato-Endocrinology · doi:10.4161/derm.2.1.12490 · Cited by 245
Cited by
Sabat, R., Jemec, G. B. E., Matusiak, Ł., Kimball, A. B., Prens, E., & Wolk, K. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0149-1 · Cited by 573
Self-citationNguyen, T. V., Damiani, G., Orenstein, L. A. V., Hamzavi, I., & Jemec, G. B. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16677 · Cited by 391
Self-citationUnmet medical needs in chronic, non-communicable inflammatory skin diseases
Ujiie, H., Rosmarin, D., Schön, M. P., Ständer, S., Boch, K., Metz, M., Maurer, M., Thaci, D., Schmidt, E., Cole, C., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.875492 · Cited by 158
“It is a dynamic score based on the number of nodules, abscesses, and draining tunnels and allows dividing the severity of the disease into mild, moderate, severe (131).”
BackgroundHidradenitis Suppurativa: Where We Are and Where We Are Going
Scala, E., Cacciapuoti, S., Garzorz-Stark, N., Megna, M., Marasca, C., Seiringer, P., Volz, T., Eyerich, K., & Fabbrocini, G. (2021) · Cells · doi:10.3390/cells10082094 · Cited by 135
New and Emerging Targeted Therapies for Hidradenitis Suppurativa
Markota Čagalj, A., Marinović, B., & Bukvić Mokos, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073753 · Cited by 74
Metadata
- Authors
- Zouboulis, C. C., Tzellos, T., Kyrgidis, A., Jemec, G. B. E., Bechara, F. G., Giamarellos‐Bourboulis, E. J., Ingram, J. R., Kanni, T., Karagiannidis, I., Martorell, A., Matusiak, Ł., Pinter, A., Prens, E. P., Presser, D., Schneider‐Burrus, S., von Stebut, E., Szepietowski, J. C., Zee, H. H., Wilden, S. M., Sabat, R., the European Hidradenitis Suppurativa Foundation Investigator Group, Sinclair, R., Vekic, D., Haes, P., Marmol, V., Alavi, A., Gulliver, W., Nassif, A., Nikolakis, G., Podda, M., Antoniou, C., Delli, F. S., Dessinioti, C., Patsatsi, A., Trigoni, A. P., Zisimou, C., Bettoli, V., Garcovich, S., Boer, J., Horváth, B., Ingvarsson, G., Puig, L., Hunger, R. E., Emtestam, L., Danby, F. W., & Kimball, A. B.
- Venue
- British Journal of Dermatology
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-10-30
- Volume
- 177
- Issue
- 5
- Pages
- 1401-1409
- ISSN
- 0007-0963 (ISSN-L)
- 1365-2133
- OpenAlex
- W2694182897
- Cited by
- 493
- References
- 1
- FWCI
- 28.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zouboulis, C. C., Tzellos, T., Kyrgidis, A., Jemec, G. B. E., Bechara, F. G., Giamarellos‐Bourboulis, E. J., Ingram, J. R., Kanni, T., Karagiannidis, I., Martorell, A., Matusiak, Ł., Pinter, A., Prens, E. P., Presser, D., Schneider‐Burrus, S., von Stebut, E., Szepietowski, J. C., Zee, H. H., Wilden, S. M., . . . Kimball, A. B. (2017). Development and validation of the International Hidradenitis Suppurativa Severity Score System ( IHS 4), a novel dynamic scoring system to assess HS severity. British Journal of Dermatology. https://doi.org/10.1111/bjd.15748
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