The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects
Open accessAbstract
Emerging work demonstrates the dual regulation of mitochondrial function by hydrogen sulfide (H 2 S), including, at lower concentrations, a stimulatory effect as an electron donor, and, at higher concentrations, an inhibitory effect on cytochrome C oxidase. In the current article, we overview the pathophysiological and therapeutic aspects of these processes. During cellular hypoxia/acidosis, the inhibitory effect of H 2 S on complex IV is enhanced, which may shift the balance of H 2 S from protective to deleterious. Several pathophysiological conditions are associated with an overproduction of H 2 S (e.g. sepsis), while in other disease states H 2 S levels and H 2 S bioavailability are reduced and its therapeutic replacement is warranted (e.g. diabetic vascular complications). Moreover, recent studies demonstrate that colorectal cancer cells up‐regulate the H 2 S‐producing enzyme cystathionine β‐synthase (CBS), and utilize its product, H 2 S, as a metabolic fuel and tumour‐cell survival factor; pharmacological CBS inhibition or genetic CBS silencing suppresses cancer cell bioenergetics and suppresses cell proliferation and cell chemotaxis. In the last chapter of the current article, we overview the field of H 2 S‐induced therapeutic ‘suspended animation’, a concept in which a temporary pharmacological reduction in cell metabolism is achieved, producing a decreased oxygen demand for the experimental therapy of critical illness and/or organ transplantation. Linked Articles: This article is part of a themed issue on Mitochondrial Pharmacology: Energy, Injury & Beyond. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2014.171.issue‐8
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Citations
Cites
Oxidative stress and diabetic complications
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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
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The role of mitochondria in protection of the heart by preconditioning
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Targeting aspartate aminotransferase in breast cancer
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Cited by
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Cirino, G., Szabo, C., & Papapetropoulos, A. (2023) · Physiological Reviews · doi:10.1152/physrev.00028.2021 · Cited by 553
Self-citationSzabo, C., Ransy, C., Módis, K., Andriamihaja, M., Murghes, B., Coletta, C., Olah, G., Yanagi, K., & Bouillaud, F. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12369 · Cited by 440
Self-citationSzabo, C., & Papapetropoulos, A. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014050 · Cited by 423
Self-citationHydrogen sulfide: An endogenous regulator of the immune system
Dilek, N., Papapetropoulos, A., Toliver-Kinsky, T., & Szabo, C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105119 · Cited by 292
Self-citationEffects of hydrogen sulfide on mitochondrial function and cellular bioenergetics
Paul, B. D., Snyder, S. H., & Kashfi, K. (2021) · Redox Biology · doi:10.1016/j.redox.2020.101772 · Cited by 284
Metadata
- Authors
- Módis, K., Bos, E. M., Calzia, E., van Goor, H., Coletta, C., Papapetropoulos, A., Hellmich, M. R., Radermacher, P., Bouillaud, F., & Szabo, C.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2014-03-28
- Volume
- 171
- Issue
- 8
- Pages
- 2123-2146
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1516260708
- Cited by
- 163
- References
- 12
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
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