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Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Open accessAbstract
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids that act as extracellular signals. The signalling properties are mediated by 7‐transmembrane GPCRs, constituent members of which have continued to be identified after their initial discovery in the mid‐1990s. Here we briefly review this class of receptors, with a particular emphasis on their protein and gene nomenclatures that reflect their cognate ligands. There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA 1 – LPA6 and italicized gene names LPAR1‐LPAR6 (human) and Lpar1‐Lpar6 (non‐human). There are five sphingosine 1‐phosphate (S1P) receptors: protein names S1P 1‐S1P 5 and italicized gene names S1PR1‐S1PR5 (human) and S1pr1‐S1pr5 (non‐human). Recent additions to the lysophospholipid receptor family have resulted in the proposed names for a lysophosphatidyl inositol (LPI) receptor – protein name LPI 1 and gene name LPIR1 (human) and Lpir1 (non‐human) – and three lysophosphatidyl serine receptors – protein names LyPS 1, LyPS 2, LyPS 3 and gene names LYPSR1‐LYPSR3 (human) and Lypsr1‐Lypsr3 (non‐human) along with a variant form that does not appear to exist in humans that is provisionally named LyPS 2L. This nomenclature incorporates previous recommendations from the International U nion of B asic and C linical P harmacology, the H uman G enome O rganization, the Gene Nomenclature Committee, and the M ouse G enome I nformatix.
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Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity
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Metadata
- Authors
- Kihara, Y., Maceyka, M., Spiegel, S., & Chun, J.
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2014-07-12
- Volume
- 171
- Issue
- 15
- Pages
- 3575-3594
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W1549006420
- Cited by
- 324
- References
- 212
- FWCI
- 11.44
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
