Community guidelines for GPCR ligand bias: IUPHAR review 32

Cited by (234)

Items 201–234 of 234

1. Cryo-EM elucidation of stoichiometric plasticity, asymmetric ligand recognition and allosteric coupling in human P2X2/3 heterotrimeric channels
   Dong-Ping Wang, Wanbiao Chen, Xiao-Na Yang, Meng-Yang Sun, Ai-Xin Zhang, Yuan Gao, Xi Chen, Bin Cui, Xing Zhou, Yu Gao et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
2. Potassium depolarized rat uterus in response to oxytocin and its structural analogues: kinetic analysis
   V. Pliška, Denis Crankshaw · 2026 · Canadian Journal of Physiology and Pharmacology
3. GPCR kinases shape ACKR4 functions via differential C-terminal phosphorylation
   Oliver J. Gerken, Rebecca Warmers, Clara Hild, Niklas Kielkopf, Nicola Catone, Roland Bruderer, Daniel F. Legler · 2026 · Nature Communications
4. Ligand-Based and Structure-Based Drug Design for G Protein-Coupled Receptors
   Hanumanthappa Krishnappa Makari, Geetanjali Sageena, D S N B K Prasanth · 2026 · Springer eBooks
5. GPCR Drug Development from Preclinical Insights to Clinical Applications
   Vaibhavkumar Patel, Maitree Chauhan, Arya Nair, Kinjal Prahaladbhai Patel, Prashant Tiwari, Sunil Kumar Kadiri, Babita Kaundal · 2026 · Springer eBooks
6. Comparative analysis reveals molecular adaptation of mammalian HCA2 to microbial metabolites
   Franziska Bischof, Petra Krumbholz, Gunnar Kleinau, Patrick Scheerer, Claudia Stäubert · 2026 · iScience
7. NLRs and STANDs: a class of enthalpy and entropy dual-driven allosteric switches varying information entropies
   Peng Liu · 2026 · Progress in Biophysics and Molecular Biology
8. PN6047 Demonstrates Broad Preclinical Efficacy in Headache Models as a Novel Delta-Opioid Receptor Agonist
   Yaseen Awad-Igbaria, Yanping Zhang, Mattin Aframian, Guido C. Faas, Andrew Charles, Serapio M. Baca, Emily M. Jutkiewicz, Bengt von Mentzer, John R. Traynor, David Kendall et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
9. Discovery of Small Molecule Ligands Targeting Orphan G Protein-Coupled Receptors GPR3, GPR6, and GPR12
   Xiaochen Tian, Saghir Ali, Jones A. Addiah-Nickson, Haiying Chen, John A. Allen, Jia Zhou · 2026 · Journal of Medicinal Chemistry
10. Impact of Time, Temperature, and Conformational Changes on the Characterization of Cardiotonic Steroid–Na+/K+-ATPase Interactions
    Pedro Azalim-Neto, Leandro Augusto Barbosa, Cristóforo Scavone, Luis Eduardo M. Quintas · 2026 · The Journal of Membrane Biology
11. Mechanisms and Manifestations of Ligand Bias in Signaling: Focus on Receptor Tyrosine Kinases
    Ryan J. Schuck, Tanaya Roy, Ana-Nicoleta Bondar, P. Krejci, Kalina Hristova · 2026 · Chemical Reviews
12. G protein signaling capabilities at the bradykinin 2 receptor
    Shradha V. Darira, Laurie P. Sutton · 2026 · Naunyn-Schmiedeberg s Archives of Pharmacology
13. GLP-1-based multipharmacology: Biased signaling as a determinant of therapeutic efficacy
    Wenzhuo Li, Jiahui Yan, Fenghui Zhao, Dehua Yang · 2026 · Annual reports in medicinal chemistry
14. Ligand-Dependent Affinity but State-Dominated Efficacy in Structure-Based GPCR Pharmacology Prediction
    Jianxiang Huang, Xin Qiao, Chunhao Zhu, Xiaobing Lan, Shaoyong Lu · 2026 · Journal of Medicinal Chemistry
15. Orphan GPCRs in diabetes mellitus: metabolic control, inflammation, and drug development
    Chandrabose Sureka, Vikraman Muniyandi, Ayman Geddawy, Thiyagarajan Ramesh, Akshaya Murugesan, Meenakshisundaram Kandhavelu · 2026 · Frontiers in Endocrinology
16. Ligand bias in the EGF receptor system
    LINDA JOY PIKE · 2026 · Philosophical Transactions of the Royal Society B Biological Sciences
17. The promise of biased ligands in therapeutics
    Dylan Scott Eiger, Jeffrey S. Smith, Sudarshan Rajagopal · 2026 · Pharmacological Reviews
18. Microswitch-Guided Sampling for the Detection of Ligand Signaling Bias in GPCR Systems
    Paulina Dragan, Dorota Latek · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
19. High-affinity ELR+ CXC chemokines display balanced G protein-, GRK- and β-arrestin-associated transducer engagement at the viral G protein-coupled receptor ORF74
    QianQian Kong, Brent Van Bosstraeten, Steven De Jonghe, Dominique Schols, Tom Van Loy · 2026 · Frontiers in Pharmacology
20. Beyond the tongue: The emerging role of system bias and biased signaling in bitter taste receptor (TAS2R) function and nutrition
    A.U. Mueller, Phil Richter, G. Andersen, V. Palacino Chacon, Veronika Somoza · 2026 · Trends in Food Science & Technology
21. Mapping the N/OFQ(1−13)-NH2 Address Domain to Identify G Protein-Biased NOP Receptor Agonists
    Giulio Meneguzzo, Erika Morrone, Daniele Scarpa, Alessandra Rizzo, Erika Marzola, Antonella Ciancetta, Davide Illuminati, Valentina Albanese, Tiziano De Ventura, Delia Preti et al. · 2026 · Journal of Medicinal Chemistry
22. Design and Development of New Dual Target Agents, Cannabinoid Subtype 2 Receptor (CB2R) Agonists, and Fatty Acid Amide Hydrolase (FAAH) Inhibitors against Neurodegeneration
    Giovanni Graziano, Francesco Mastropasqua, Annalisa Fanizzi, M. Papadopoulos, Antonio Laghezza, Mariachiara Mammone, Gabriella Rosanna Musillo, Giuseppe Felice Mangiatordi, Jose Manuel Brea, Marı́a Isabel Loza et al. · 2026 · Journal of Medicinal Chemistry
23. Gut microbiota-derived small molecules, peptides, and proteins in GPCR signaling: current evidence for β-arrestin involvement
    Yushan Hu, Yiru Liu, Haiyan Yao, Siteng Wang, Yice Gao, Ruixue Li, Hui Sun · 2026 · Frontiers in Microbiology
24. Development of Potent G Protein Pathway-Biased GPR183 Agonists
    Kaustubh R. Bhuskute, Asmita Manandhar, Viktoria M. S. Kjær, Francesco Casartelli, Gertrud M. Hjortø, Maria Ioanna Koutsaki, Udhayabhaskar Sathyanarayanan, Emilia Hjortkilde, Rita Turcio, METTE MARIE ROSENKILDE et al. · 2026 · Journal of Medicinal Chemistry
25. Atomic, structural and molecular insights into GPCR ligand binding and signalling
    Katarina Nemec, Bálint Mészáros, Georgios Skiniotis, Scott C. Blanchard, M. Madan Babu · 2026 · Nature Reviews Molecular Cell Biology
26. Biased signaling of endothelial GPCRs as a therapeutic frontier in atherosclerosis
    Durlav Chowdhury, Saptarshi Mukherjee, Priyanka Dubey, Sarvesh K. Paliwal, Devi Prasad Pandey, Surendra Haribhau Bodakhe · 2026 · Journal of Receptors and Signal Transduction
27. Innovative Approach Reveals How Receptors Control G Protein State Equilibria
    Alexandre Bouyssou, Mélanie Da Silva, Julien Soulé, Ludovic Fabre, Laurent Lamarque, Rémy Sounier, Thierry Durroux, Sébastien Granier, Thomas Roux, Elodie Dupuis et al. · 2026 · Advanced Science
28. Structure–signal relationships at κ-opioid receptor (KOR) revealed by bicyclo[2.2.2]octene enamide derivatives
    Ruburika Nagao, Keita Kajino, Ryoji Kise, Shun Yokoi, Tomoya Sugai, Risako Katamoto, Riko Suzuki, Mitsuki Hashimoto, Shigeto Hirayama, Takatsugu Hirokawa et al. · 2026 · European Journal of Medicinal Chemistry
29. BindingDB Entry 50015822: Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation.
    BindingDB · 2023 · UC San Diego
30. BindingDB Entry 50019888: Exploring Structural Determinants of Bias among D4 Subtype-Selective Dopamine Receptor Agonists.
    BindingDB · 2024 · UC San Diego
31. BindingDB Entry 50017311: Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
    BindingDB · 2023 · UC San Diego
32. FAIRsharing record for: Information system for G protein-coupled receptors
    FAIRsharing Team, Albert Kooistra · 2015 · FAIRsharing.org
33. BindingDB Entry 50021325: The formyl peptide receptors FPR1 and FPR2 as targets for inflammatory disorders: recent advances in the development of small-molecule agonists.
    BindingDB · 2025 · UC San Diego
34. The Potency Problem in GPCR Biased Agonism
    Cassandra J. Hatzipantelis · 2026 · ACS Chemical Neuroscience