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The natural product argentatin C attenuates postoperative pain via inhibition of voltage‐gated sodium and T‐type voltage‐gated calcium channels
Abstract
Background and Purpose: Postoperative pain occurs in as many as 70% of surgeries performed worldwide. Postoperative pain management still relies on opioids despite their negative consequences, resulting in a public health crisis. Therefore, it is important to develop alternative therapies to treat chronic pain. Natural products derived from medicinal plants are potential sources of novel biologically active compounds for development of safe analgesics. In this study, we screened a library of natural products to identify small molecules that target the activity of voltage‐gated sodium and calcium channels that have important roles in nociceptive sensory processing. Experimental Approach: Fractions derived from the Native American medicinal plant, Parthenium incanum, were assessed using depolarization‐evoked calcium influx in rat dorsal root ganglion (DRG) neurons. Further separation of these fractions yielded a cycloartane‐type triterpene identified as argentatin C, which was additionally evaluated using whole‐cell voltage and current‐clamp electrophysiology, and behavioural analysis in a mouse model of postsurgical pain. Key Results: Argentatin C blocked the activity of both voltage‐gated sodium and low‐voltage‐activated (LVA) calcium channels in calcium imaging assays. Docking analysis predicted that argentatin C may bind to Na V 1.7–1.9 and Ca V 3.1–3.3 channels. Furthermore, argentatin C decreased Na+ and T‐type Ca 2+ currents as well as excitability in rat and macaque DRG neurons, and reversed mechanical allodynia in a mouse model of postsurgical pain. Conclusion and Implications: These results suggest that the dual effect of argentatin C on voltage‐gated sodium and calcium channels supports its potential as a novel treatment for painful conditions.
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Argentatins have immunomodulatory, anti-inflammatory and analgesic activities.
“have previously been shown to have immunomodulatory [13], anti‐inflammatory [14, 15, 16] and analgesic [17] activities”
From Synergistic Potential of Argentatins A and B to Improve 5‐Fluorouracil Cytotoxicity in Colorectal Cancer Cell Models (2024) · cites this paper as [17]
Citations
Cites
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000410 · Cited by 5,939
Accurate prediction of protein structures and interactions using a 3-track network
Baek, M., DiMaio, F., Anishchenko, I., Dauparas, J., Ovchinnikov, S., Lee, G. R., Wang, J., Cong, Q., Kinch, L. N., Schaeffer, R. D., et al. (2021) · doi:10.1101/2021.06.14.448402 · Cited by 5,549
Curtis, M. J., Alexander, S., Cirino, G., Docherty, J. R., George, C. H., Giembycz, M. A., Hoyer, D., Insel, P. A., Izzo, A. A., Ji, Y., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14153 · Cited by 1,338
Automated design of ligands to polypharmacological profiles
Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X.-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., et al. (2012) · Nature · doi:10.1038/nature11691 · Cited by 832
Parra-Delgado, H., García-Pillado, F., Sordo, M., Ramírez-Apan, T., Martínez-Vázquez, M., & Ostrosky-Wegman, P. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.024 · Cited by 29
Anti-inflammatory and Cytotoxic Cycloartanes from Guayule ( Parthenium Argentatum )
Flores-Rosete, G., & Martínez-Vázquez, M. (2008) · Natural Product Communications · doi:10.1177/1934578x0800300318 · Cited by 11
Flagged first, then by citations
Research works printed but not linked: 61
- 10.1111/bph.15538 · DOI
- 10.1111/bph.15537 · DOI
- 10.1111/bph.15543 · DOI
- 10.1111/bph.15539 · DOI
- 10.1126/science.abj8754 · DOI · Paper page
- 10.1085/jgp.91.3.421 · DOI
- 10.1097/j.pain.0000000000001385 · DOI
- 10.1152/physrev.00052.2017 · DOI · Paper page
- 10.1007/s00709-019-01411-0 · DOI
- 10.1021/acschemneuro.8b00617 · DOI
- 10.1016/j.trsl.2021.01.002 · DOI
- 10.1126/scitranslmed.abh1314 · DOI
- Castetter E. F., 1936, Ethnobiological studies in the American Southwest
- 10.1016/0165-0270(94)90144-9 · DOI
- 10.3390/molecules20011610 · DOI
- 10.1038/nature05413 · DOI
- 10.1172/JCI33297 · DOI
- 10.1073/pnas.1610531113 · DOI
- 10.1073/pnas.2110932119 · DOI
- 10.1097/j.pain.0000000000000147 · DOI
- 10.1021/jm0306430 · DOI · Paper page
- 10.1113/jphysiol.2003.047357 · DOI
- 10.3390/healthcare9030333 · DOI
- 10.1208/s12248-020-00472-x · DOI
- 10.1111/jnc.12070 · DOI
- 10.1177/1744806918765808 · DOI
- 10.1002/mrc.1260240611 · DOI
- 10.7554/eLife.48118 · DOI
- 10.1111/bph.15178 · DOI · Paper page
- 10.1007/s10822-013-9644-8 · DOI
- Martinez M., 1969, Las Plantas Medicinales de Mexico
- 10.1126/scitranslmed.aay9056 · DOI
- 10.1097/j.pain.0000000000000555 · DOI
- 10.1111/bph.13737 · DOI
- 10.1073/pnas.0404915101 · DOI
- 10.1016/j.bmc.2005.10.038 · DOI
- 10.1016/j.bmcl.2004.12.038 · DOI
- 10.1097/00000542-200310000-00041 · DOI
- 10.1097/pr9.0000000000000588 · DOI
- Powell A. M., 1998, Trees and shrubs of the trans‐pecos and adjacent areas
- 10.1055/s-0043-123472 · DOI
- Rodriguez‐Hahn L. R. D. V. A., 1970, Structure of argentatines A, B, and C from Parthenium argentatum, Revista Latinoamericana de Quimica, 1, 24
- Romo de Vivar A., 1986, X‐ray crystallographic studies of incaline and argentatine B., Revista Latinoamericana de Quimica, 17, 7
- 10.1021/acschemneuro.7b00200 · DOI
- 10.1186/s13041-020-00676-4 · DOI
- Schrödinger, LLC, 2018, The PyMOL Molecular Graphics System, Version 2.0
- Schrödinger, LLC, 2020, Schrödinger Release 2020‐4
- 10.1021/acschemneuro.9b00166 · DOI
- 10.1126/science.aaw2493 · DOI
- 10.1523/JNEUROSCI.1049-18.2018 · DOI
- 10.1017/s0265021507003031 · DOI · Paper page
- 10.4155/fmc-2016-0232 · DOI
- 10.1007/s40263-014-0151-9 · DOI
- 10.1016/s0140-6736(08)60878-8 · DOI
- 10.1016/j.cell.2012.03.041 · DOI
- 10.1021/np200769q · DOI
- 10.1021/acsomega.1c01714 · DOI
- 10.1124/pr.114.009654 · DOI
- 10.1038/s41586-019-1801-3 · DOI
- 10.1186/s13041-020-00616-2 · DOI
- 10.1021/acschemneuro.9b00547 · DOI
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Sánchez‐Olivares, P., Silva‐Nolasco, A. M., de la Cruz‐Morcillo, M. A., García‐Martínez, M. M., Pinedo‐Serrano, A., Carmona, M., & Galán‐Moya, E. M. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70294 · Cited by 5
Metadata
- Authors
- Duran, P., Loya‐López, S., Ran, D., Tang, C., Calderon‐Rivera, A., Gomez, K., Stratton, H. J., Huang, S., Xu, Y., Wijeratne, E. M. K., Perez‐Miller, S., Shan, Z., Cai, S., Gabrielsen, A. T., Dorame, A., Masterson, K. A., Alsbiei, O., Madura, C. L., Luo, G., Moutal, A., Streicher, J., Zamponi, G. W., Gunatilaka, A. A. L., & Khanna, R.
- Affiliations
- New York University (US)
- University of Arizona (US)
- Hunan Normal University (CN)
- Department of Molecular Pathobiology, College of Dentistry New York University New York New York USA
- University of Calgary (CA)
- NYU Langone Health (US)
- Corresponding author
- Khanna, Rajesh
- ORCID
- Venue
- British Journal of Pharmacology
- Publisher
- Wiley
- Published
- 2023-01-15
- Volume
- 180
- Issue
- 9
- Pages
- 1267-1285
- ISSN
- 0007-1188 (ISSN-L)
- 1476-5381
- OpenAlex
- W4306392786
- Cited by
- 19
- References
- 6
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 7 · 2023: 4
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA042852, DA050364, DA050364‐01)
- National Institute of Neurological Disorders and Stroke (NS098772, NS120663)
- University of Arizona
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- postoperative pain, voltage-gated sodium channels, T-type calcium channels, cycloartane triterpenoids, dorsal root ganglion neurons, mechanical allodynia, opioid alternatives, nociception
- MeSH terms
- Animals, Calcium, Ganglia, Spinal, Pain, Postoperative, Postoperative Pain, Sodium, Rats, Sprague-Dawley, Calcium Channels, T-Type, Mice, Rats, Voltage-Gated Sodium Channels
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