The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis
Open accessAbstract
Nasopharyngeal cancer (NPC) is an endemic type of head and neck cancer with a high rate of cervical lymph node metastasis. Metastasis is the major cause of death in NPC patients. Increasing evidence indicates that exosomes play a pivotal role in promoting cancer metastasis by enhancing angiogenesis and ECM degradation. Matrix metalloproteinase 13 is an important kind of matrix proteinase that is often overexpressed in various tumors and increases the risk of metastasis. However, little is known about the potential role of MMP 13‐containing exosomes in NPC. In this study, we found that MMP 13 was overexpressed in NPC cells and exosomes purified from conditioned medium (CM) as well as NPC patients’ plasma. Transwell analysis revealed that MMP 13‐containing exosomes facilitated the metastasis of NPC cells. Furthermore, si RNA inhibited the effect of MMP 13‐containing exosomes on tumor cells metastasis as well as angiogenesis. The current findings provided novel insight into the vital role of MMP 13‐containing exosomes in NPC progression which might offer unique insights for potential therapeutic strategies for NPC progressions.
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Mu, W., Rana, S., & Zöller, M. (2013) · Neoplasia · doi:10.1593/neo.13786 · Cited by 248
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Metadata
- Authors
- You, Y., Shan, Y., Chen, J., Yue, H., You, B., Shi, S., Li, X., & Cao, X.
- Venue
- Cancer Science
- Publisher
- Wiley
- Published
- 2015-10-13
- Volume
- 106
- Issue
- 12
- Pages
- 1669-1677
- ISSN
- 1347-9032 (ISSN-L)
- 1349-7006
- OpenAlex
- W1898690520
- Cited by
- 176
- References
- 1
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- You, Y., Shan, Y., Chen, J., Yue, H., You, B., Shi, S., Li, X., & Cao, X. (2015). Matrix metalloproteinase 13‐containing exosomes promote nasopharyngeal carcinoma metastasis. Cancer Science. https://doi.org/10.1111/cas.12818
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
