Cited by 46Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryOphthalmology and Eye Disorders

Graves’ disease following immune reconstitution or immunomodulatory treatment: should we manage it any differently?

Weetman, Anthony P.·2014·Clinical Endocrinology

Abstract

Graves' disease and other disorders of thyroid function may occur following treatment with novel anticancer agents or during periods of lymphocyte recovery after lymphopenia. There are three main settings for such lymphocyte reconstitution: recovery after a bone marrow or haematopoietic stem cell transplant, alemtuzumab treatment and the use of highly active antiretroviral therapy (HAART) for human immunodeficiency virus infection. The available evidence suggests that Graves' disease behaves as normal in most of these cases and should be treated conventionally, but it may follow a more favourable course in those receiving alemtuzumab or HAART. As spontaneous or drug-induced remission may be more likely in these two settings, first-line treatment should usually consist of an antithyroid drug.

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Crossref · 10.1111/cen.12427

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Authors
Weetman, A. P.
Affiliations
University of Sheffield (GB)
Corresponding author
Weetman, Anthony P.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2014-04-09
Volume
80
Issue
5
Pages
629-632
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
OpenAlex
W1969069960
Cited by
46
References
30
Citations by year
2025: 2 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 2
FWCI
4.29
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
Keywords
Graves' disease, immune reconstitution, immunomodulatory therapy, alemtuzumab, highly active antiretroviral therapy, HIV infection, hematopoietic stem cell transplantation, bone marrow transplantation, lymphopenia, drug-induced thyroid dysfunction, antithyroid drugs, drug-induced remission
MeSH terms
Alemtuzumab, Bone Marrow Cells, Endocrinology, Graves Disease, Humans, Immune System, Lymphocytes, Lymphopenia, Neoplasms, Remission Induction, Hematopoietic Stem Cell Transplantation, Antiretroviral Therapy, Highly Active, Antibodies, Monoclonal, Humanized

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