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Cited by 82Bone health and osteoporosis researchAdipokines, Inflammation, and Metabolic DiseasesBone Metabolism and Diseases

The effects of aerobic exercise training on serum osteocalcin, adipocytokines and insulin resistance on obese young males

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Kim, Yu‐Sik, Nam, Ji Sun, Yeo, Dong‐Wook, Kim, Kyung Rae, Suh, Sang‐Hoon, Ahn, Chul Woo·2015·Clinical Endocrinology
DOI 10.1111/cen.12601
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Abstract

OBJECTIVE: Osteocalcin has been proposed to be a novel link between bone and energy metabolism. Previous studies showed its relations to exercise, body fat and glucose metabolism, but their interrelationship remains inconslusive. We evaluated the changes in osteocalcin level following 8-week exercise programme and assessed how they are related to concomitant changes in body fat composition, insulin resistance and various adipocytokines in a single centre, randomized and prospective design. STUDY DESIGN AND METHODS: A total of 39 young obese, otherwise healthy males were randomly assigned to control (n = 10) and exercise (n = 29) groups. Subjects in Exercise group were on 8-week supervised exercise training programme of four sessions per week. Body fat compositions were analysed using whole body bone mineral density, various metabolic parameters, osteocalcin and adipocytokines were assessed from fasting blood samples before and after 8-week exercise programme. RESULTS: Body fat reduction following exercise significantly increased serum total (1·51 ± 0·36 vs 1·69 ± 0·39 mmol/l, P = 0·01, baseline vs postexercise) and undercarboxylated osteocalcin level (0·44 ± 0·14 vs 0·64 ± 0·26 mmol/l, P < 0·01), and the increase in osteocalcin was in negative correlations with changes in body weight, BMI and body fat percentage as well as HOMA-IR and leptin (all P < 0·05). The changes in osteocalcin and leptin were not independent predictors of changes in insulin resistance and osteocalcin, respectively. CONCLUSIONS: In a physiological axis of bone-fat-energy metabolism, exercise-induced body fat reduction and improved insulin sensitivity were accompanied by an increase in serum osteocalcin and leptin levels, but other factors also seem to be involved in this interrelationship.

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Crossref · 10.1111/cen.12601

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  • Osteocalcin, mainly synthesized and released by osteoblasts, is involved in increasing muscular mitochondria, inhibiting myoblast proliferation and bone formation, and regulating energy homeostasis, and is known to increase during 8-week treadmill running in obese young males.

    “Osteocalcin, mainly synthesized and released by osteoblasts, is involved in increasing muscular mitochondria, inhibiting myoblast proliferation and bone formation, and regulating energy homeostasis, known to increase during 8-week treadmill running (65–75% VO2max per session, four sessions per week) in obese young males [137].”

    From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [137]

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Authors
Kim, Y., Nam, J. S., Yeo, D., Kim, K. R., Suh, S., & Ahn, C. W.
Affiliations
  • Department of Internal Medicine Yonsei University College of Medicine Seoul Korea
  • Yonsei University (KR)
  • Laboratory of Physiological Hygene and Exercise Science School of Kinesiology University of Minnesota Minneapolis MN USA
Corresponding author
  • Suh, Sang‐Hoon
  • Ahn, Chul Woo
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2014-11-04
Volume
82
Issue
5
Pages
686-694
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/cen.12601
OpenAlex
W2006249005
Cited by
82
References
33
Citations by year
2026: 2 · 2025: 7 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 9 · 2016: 5 · 2015: 7
FWCI
7.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
osteocalcin, aerobic exercise training, obesity, insulin resistance, adipokines, leptin, undercarboxylated osteocalcin, fat loss, young men, HOMA-IR
MeSH terms
Adult, Cross-Sectional Studies, Energy Metabolism, Humans, Insulin Resistance, Male, Obesity, Prospective Studies, Exercise, Osteocalcin, Body Mass Index, Leptin, Adiposity, Adipokines, Young Adult

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