Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community‐dwelling men
Abstract
Summary: Objectives: Lower circulating androgens and poorer lung function are associated with increased cardiovascular risk and mortality in men. The association between androgens and lung function is unclear. We tested the hypothesis that circulating testosterone (T) and its metabolites dihydrotestosterone (DHT) and oestradiol (E2) are differentially associated with lung function in men. Methods: Early‐morning serum T, DHT and E2 were assayed using mass spectrometry in 1768 community‐dwelling men from Busselton, Western Australia. Forced expiratory volume in 1 s (FEV 1) and forced vital capacity (FVC) were measured using spirometry. Linear regression models adjusting for age, height, smoking, exercise, body mass index, respiratory conditions and cardiovascular risk factors were used. Results: Mean age was 50.1 ± 16·8 years. 16·0% were current smokers, 14·1% reported a history of asthma and 2·7% reported chronic obstructive pulmonary disease. Current smokers had higher T compared with never smokers (age‐adjusted mean 14·5 vs 13·5 nmol/l, P = 0·002) and higher E2 (65·3 vs 60·1 pmol/l, P = 0·017). In fully adjusted analyses, T was associated with FEV 1 (51 ml per 1 SD increase, P < 0·001) as was DHT (62 ml, P < 0·001), E2 was not (P = 0·926). Similar results were seen for FVC (T: 76 ml, P < 0·001; DHT: 65 ml, P < 0·001; E2 P = 0·664). Higher DHT was marginally associated with the ratio FEV 1/FVC (0·3% per 1 SD increase, P = 0·047). Conclusions: Both T and DHT were independently associated with higher FEV 1 and FVC in predominantly middle‐aged community‐dwelling men. Androgens may contribute to, or be biomarkers for, better lung function in men. Further research is needed to clarify whether androgens preserve lung function in ageing men.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The current findings are largely consistent with past efforts to estimate the number of caregivers who have died of COVID-19.
“The current findings are largely consistent with past efforts to estimate the number of caregivers who have died of COVID-19 [14]; [19].”
From Parental and Other Caregiver Loss Due to COVID-19 in the United States: Prevalence by Race, State, Relationship, and Child Age (2023) · cites this paper as [19]
Cites
Standardization of Spirometry, 1994 Update. American Thoracic Society
(1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.3.7663792 · Cited by 6,572 · see citing works
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760 · see citing works
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861 · see citing works
21st-Century Hazards of Smoking and Benefits of Cessation in the United States
Jha, P., Ramasundarahettige, C., Landsman, V., Rostron, B., Thun, M., Anderson, R. N., McAfee, T., & Peto, R. (2013) · New England Journal of Medicine · doi:10.1056/nejmsa1211128 · Cited by 1,767 · see citing works
Ding, E. L., Song, Y., Malik, V. S., & Liu, S. (2006) · JAMA · doi:10.1001/jama.295.11.1288 · Cited by 1,354 · see citing works
Endogenous Testosterone and Mortality in Men: A Systematic Review and Meta-Analysis
Araujo, A. B., Dixon, J. M., Suarez, E. A., Murad, M. H., Guey, L. T., & Wittert, G. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1137 · Cited by 671 · see citing works
Holman, C. D. J., Bass, J. A., Rosman, D. L., Smith, M. B., Semmens, J. B., Glasson, E. J., Brook, E. L., Trutwein, B., Rouse, I. L., Watson, C. R., et al. (2008) · Australian Health Review · doi:10.1071/ah080766 · Cited by 507 · see citing works
Schols, A. M. W. J., Soeters, P. B., Mostert, R., Pluymers, R. J., & Wouters, E. F. �. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.4.7551381 · Cited by 461 · see citing works
Effects of Testosterone and Resistance Training in Men with Chronic Obstructive Pulmonary Disease
Casaburi, R. H., Bhasin, S., Cosentino, L. M., Pórszász, J., Somfay, A., Lewis, M. I., Fournier, M., & Storer, T. W. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200305-617oc · Cited by 388 · see citing works
Fink, H. A., Ewing, S. K., Ensrud, K. E., Barrett-Connor, E., Taylor, B. C., Cauley, J. A., & Orwoll, E. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0173 · Cited by 319 · see citing works
Harwood, D. T., & Handelsman, D. J. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.09.003 · Cited by 243 · see citing works
Self-citationBrand, J. S., Rovers, M. M., Yeap, B. B., Schneider, H. J., Tuomainen, T., Haring, R., Corona, G., Onat, A., Maggio, M. G., Bouchard, C., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100409 · Cited by 213 · see citing works
Self-citationYeap, B. B., Alfonso, H. S., Chubb, S. A. P., Handelsman, D. J., Hankey, G. J., Almeida, O. P., Golledge, J., Norman, P. E., & Flicker, L. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3272 · Cited by 188 · see citing works
Self-citationYeap, B. B., Alfonso, H., Chubb, S. A. P., Handelsman, D. J., Hankey, G. J., Norman, P. E., & Flicker, L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2265 · Cited by 155 · see citing works
Self-citationCauley, J. A., Ewing, S. K., Taylor, B. C., Fink, H. A., Ensrud, K. E., Bauer, D. C., Barrett-Connor, E. L., Marshall, L. M., & ORWOLL, E. S. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2635 · Cited by 126 · see citing works
Endocrinological disturbances in chronic obstructive pulmonary disease
Creutzberg, E. C., & Casaburi, R. H. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004610 · Cited by 113 · see citing works
Svartberg, J. B., Aasebø, U., Hjalmarsen, A., Sundsfjord, J., & Jorde, R. (2004) · Respiratory Medicine · doi:10.1016/j.rmed.2004.02.015 · Cited by 111 · see citing works
Endogenous testosterone levels and smoking in men. The fifth Tromsø study
Svartberg, J., & Jorde, R. (2007) · International Journal of Andrology · doi:10.1111/j.1365-2605.2006.00720.x · Cited by 111 · see citing works
Effect of cigarette smoking on levels of bioavailable testosterone in healthy men
ENGLISH, K. M., PUGH, P. J., PARRY, H., SCUTT, N. E., CHANNER, K. S., & JONES, T. H. (2001) · Clinical Science · doi:10.1042/cs1000661 · Cited by 107 · see citing works
Yeap, B. B., Alfonso, H. S., Chubb, S. A. P., Hankey, G. J., Handelsman, D. J., Golledge, J., Almeida, O. P., Flicker, L. A., & Norman, P. E. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2664 · Cited by 94 · see citing works
Self-citationNon‐genomic effect of testosterone on airway smooth muscle
Kouloumenta, V., Hatziefthimiou, A. A., Paraskeva, E., Gourgoulianis, K., & Molyvdas, P. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706936 · Cited by 85 · see citing works
Changes in the prevalence of asthma in adults since 1966: the Busselton health study
James, A. L., Knuiman, M. W., Divitini, M., Hui, J., Hunter, M. L., Palmer, L. J., Maier, G., & Musk, A. W. (2009) · European Respiratory Journal · doi:10.1183/09031936.00194308 · Cited by 84 · see citing works
Self-citationCombined effect of lung function level and decline increases morbidity and mortality risks
Allison, P., Marott, J. L., Lange, P., Martin, C. J., Shankar, A., Petsonk, E. L., & Hnizdo, E. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9750-2 · Cited by 81 · see citing works
Cigarette smoking has a positive and independent effect on testosterone levels
Wang, W., Yang, X., Liang, J., Liao, M., Zhang, H., Qin, X., Mo, L., Lv, W., & Mo, Z. (2013) · Hormones · doi:10.14310/horm.2002.1445 · Cited by 79 · see citing works
Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease
Karadag, F., Ozcan, H., Karul, A., Yilmaz, M., & Çildağ, O. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01501.x · Cited by 76 · see citing works
Hypogonadism in chronic obstructive pulmonary disease
Balasubramanian, V. P., & Naing, S. (2012) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e32834feb37 · Cited by 68 · see citing works
Svartberg, J. B., Schirmer, H., Medbø, A., Melbye, H., & Aasebø, U. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-006-9095-9 · Cited by 65 · see citing works
Montaño, L. M., Espinoza, J., Flores‐Soto, E., Chávez, J., & Perusquı́a, M. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0074 · Cited by 65 · see citing works
Age and secular trends in risk factors for cardiovascular disease in Busselton
Knuiman, M. W., Jamrozik, K. D., Welborn, T. A., Bulsara, M. K., Divitini, M., & Whittall, D. E. (1995) · Australian Journal of Public Health · doi:10.1111/j.1753-6405.1995.tb00389.x · Cited by 64 · see citing works
Self-citationRisk factors for androgen decline in older males: lifestyle, chronic diseases and drugs.
Isidori, A. M., & Lenzi, A. (2005) · PubMed · Cited by 62 · see citing works
Yeap, B. B., Knuiman, M. W., Divitini, M., Handelsman, D. J., Beilby, J. P., Beilin, J., McQuillan, B., & Hung, J. (2014) · Clinical Endocrinology · doi:10.1111/cen.12407 · Cited by 60 · see citing works
Self-citationKIMURA, Y., Suzuki, T., Kaneko, C., Darnel, A. D., Akahira, J., Ebina, M., Nukiwa, T., & Sasano, H. (2003) · Clinical Science · doi:10.1042/cs20030236 · Cited by 55 · see citing works
Akram, O. N., Bursill, C. A., Desai, R., Heather, A. K., Kazlauskas, R., Handelsman, D. J., & Lambert, G. C. (2011) · Analytical Chemistry · doi:10.1021/ac102845y · Cited by 52 · see citing works
Self-citationBordallo, J., de Boto, M. J. G., Meana, C., Velasco, L., Bordallo, C., Suárez, L., Cantabrana, B., & Sánchez, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.10.039 · Cited by 36 · see citing works
Androgen Physiology, Pharmacology, and Abuse
Handelsman, D. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00137-4 · Cited by 25 · see citing works
Self-citationRisk factors for respiratory symptoms in adults: The B usselton H ealth S tudy
James, A. L., Knuiman, M. W., Divitini, M., Hui, J., Hunter, M. L., Mulrennan, S. A., & Musk, A. W. (2013) · Respirology · doi:10.1111/resp.12147 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission
Stolz, D., Mkorombindo, T., Schumann, D., Agustí, A. G. N., Ash, S. Y., Bafadhel, M., Bai, C., Chalmers, J. D., Criner, G. J., Dharmage, S. C., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01273-9 · Cited by 714 · see citing works
Sex Bias in Asthma Prevalence and Pathogenesis
Shah, R., & Newcomb, D. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02997 · Cited by 228 · see citing works
Dhindsa, S., Zhang, N., McPhaul, M. J., Wu, Z. R., Ghoshal, A. K., Erlich, E. C., Mani, K. M., Randolph, G. J., Edwards, J. R., Mudd, P. A., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.11398 · Cited by 163 · see citing works
Commentary: Testosterone, a key hormone in the context of COVID-19 pandemic
Pozzilli, P., & Lenzi, A. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154252 · Cited by 162 · see citing works
Sex Steroid Hormones and Asthma in a Nationwide Study of U.S. Adults
Han, Y., Forno, E., & Celedon, J. C. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201905-0996oc · Cited by 143 · see citing works
Han, M. K., Arteaga‐Solis, E., Blenis, J., Bourjeily, G. R., Clegg, D. J., DeMeo, D. L., Duffy, J. F., Gaston, B., Heller, N. M., Hemnes, A. R., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0168ws · Cited by 97 · see citing works
Becerra-Díaz, M., Song, M., & Heller, N. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01698 · Cited by 84 · see citing works
Testosterone in males with COVID‐19: A 7‐month cohort study
Salonia, A., Pontillo, M., Capogrosso, P., Gregori, S., Carenzi, C., Ferrara, A. M., Rowe, I., Boeri, L., Larcher, A., Ramirez, G. A., et al. (2021) · Andrology · doi:10.1111/andr.13097 · Cited by 80 · see citing works
Severe asthma during childhood and adolescence: A longitudinal study
Ross, K. R., Gupta, R., DeBoer, M. D., Zein, J., Phillips, B. R., Mauger, D. T., Li, C., Myers, R., Phipatanakul, W., Fitzpatrick, A. M., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.09.030 · Cited by 72 · see citing works
Baldassarri, M., Picchiotti, N., Fava, F., Fallerini, C., Benetti, E., Daga, S., Valentino, F., Doddato, G., Furini, S., Giliberti, A., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103246 · Cited by 62 · see citing works
Testosterone replacement therapy and hospitalization rates in men with COPD
Baillargeon, J., Urban, R. J., Zhang, W., Zaiden, M. F., Javed, Z., Sheffield‐Moore, M., Kuo, Y., & Sharma, G. (2018) · Chronic Respiratory Disease · doi:10.1177/1479972318793004 · Cited by 56 · see citing works
Li, S., Zhao, Y., Yang, Y., Wang, X., Nie, M., Wu, X., Mao, J., & Veglio, F. (2020) · International Journal of Endocrinology · doi:10.1155/2020/4732021 · Cited by 56 · see citing works
Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality
Brandi, M. L., & Giustina, A. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.09.003 · Cited by 49 · see citing works
Salciccia, S., Giudice, F. D., Gentile, V., Mastroianni, C. M., Pasculli, P., Lascio, G. D., Ciardi, M. R., Sperduti, I., Maggi, M., BERARDINIS, E. D., et al. (2020) · Endocrine · doi:10.1007/s12020-020-02515-x · Cited by 50 · see citing works
Elevated Testosterone Is Associated with Decreased Likelihood of Current Asthma Regardless of Sex
Bulkhi, A. A., Shepard, K. V., Casale, T. B., & Cardet, J. C. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.05.022 · Cited by 47 · see citing works
Sex hormones and allergies: exploring the gender differences in immune responses
Gutiérrez-Brito, J. A., Lomelí-Nieto, J. Á., Muñóz-Valle, J. F., Oregon‐Romero, E., Corona-Angeles, J. A., & Hernández‐Bello, J. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2024.1483919 · Cited by 44 · see citing works
Serum free testosterone and asthma, asthma hospitalisations and lung function in British adults
Han, Y., Yan, Q., Ge, Y., Chen, W., Forno, E., & Celedon, J. C. (2020) · Thorax · doi:10.1136/thoraxjnl-2020-214875 · Cited by 44 · see citing works
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma
Zein, J., Gaston, B. M., Bazeley, P. S., DeBoer, M. D., Igo, R. P., Bleecker, E. R., Meyers, D. A., COMHAIR, S. A. A., Marozkina, N. V., Cotton, C. U., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918819117 · Cited by 43 · see citing works
Marozkina, N. V., Zein, J., DeBoer, M. D., Logan, L., Veri, L., Ross, K. R., & Gaston, B. M. (2019) · Pulmonary Therapy · doi:10.1007/s41030-019-00101-9 · Cited by 42 · see citing works
Hormonal Effects on Asthma, Rhinitis, and Eczema
Weare-Regales, N., Chiarella, S. E., Cardet, J. C., Prakash, Y. S., & Lockey, R. F. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.04.002 · Cited by 40 · see citing works
Chiarella, S. E., Cardet, J. C., & Prakash, Y. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.12.007 · Cited by 40 · see citing works
Testosterone's Role in COVID-19
Auerbach, J. M., & Khera, M. (2021) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2021.03.004 · Cited by 41 · see citing works
Menopause, lung function and obstructive lung disease outcomes: a systematic review
Campbell, B., Davis, S. R., Abramson, M. J., Mishra, G. D., Handelsman, D. J., Perret, J. L., & Dharmage, S. C. (2017) · Climacteric · doi:10.1080/13697137.2017.1392504 · Cited by 37 · see citing works
Self-citationResztak, J., Choe, J., Nirmalan, S., Wei, J., Bruinsma, J., Houpt, R., Alazizi, A., Mair-Meijers, H. E., Wen, X., Slatcher, R. B., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35742-z · Cited by 31 · see citing works
Testosterone-to-estradiol ratio and lung function in a prospective study of Puerto Rican youth
Han, Y., Forno, E., Witchel, S. F., Manni, M. L., Acosta‐Pérez, E., CANINO, G. J., & Celedon, J. C. (2021) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2021.04.013 · Cited by 27 · see citing works
Examining Male Predominance of Severe COVID-19 Outcomes: A Systematic Review
Twitchell, D. K., Christensen, M. B., Hackett, G. I., Morgentaler, A., Saad, F., & Pastuszak, A. W. (2022) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2022.0006 · Cited by 29 · see citing works
Lung function changes over 8 years and testosterone markers in both sexes: UK Biobank
Lenoir, A., Fuertes, E., Real, F. G., Leynaert, B., van der Plaat, D. A., & Jarvis, D. (2020) · ERJ Open Research · doi:10.1183/23120541.00070-2020 · Cited by 27 · see citing works
Association of Male Hypogonadism With Risk of Hospitalization for COVID-19
Dhindsa, S., Champion, C. D., Deol, E. S., Lui, M., Campbell, R. G., Newman, J., Yeggalam, A., Nadella, S., Ahir, V., Shrestha, E., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.29747 · Cited by 24 · see citing works
Treglia, D., Cutuli, J. J., Arasteh, K., & Bridgeland, J. (2023) · Journal of Community Health · doi:10.1007/s10900-022-01160-x · Cited by 19 · see citing works
Low serum DHEA-S is associated with impaired lung function in women
Pesce, G., Triebner, K., van der Plaat, D. A., Courbon, D., Hustad, S., Sigsgaard, T., Nowak, D., Heinrich, J., Antó, J. M., Arenas, S. D., et al. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100389 · Cited by 19 · see citing works
Wasti, B., Chen, Z., He, Y., Duan, W., Liu, S., & Xiang, X. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7097797 · Cited by 18 · see citing works
Salciccia, S., Giudice, F. D., Eisenberg, M. L., Mastroianni, C. M., BERARDINIS, E. D., Ricciuti, G. P., Maggi, M., & Sciarra, A. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820969019 · Cited by 16 · see citing works
Association of perfluoroalkyl substances with pulmonary function in adolescents (NHANES 2007–2012)
Shi, S., Ding, Y., Wu, B., Hu, P., Chen, M., Dong, N., Vinturache, A., Gu, H., Dong, X., & Ding, G. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26119-w · Cited by 15 · see citing works
Health Disparities in Environmental and Occupational Lung Disease
Brigham, E. P., Allbright, K., & Harris, D. A. (2020) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2020.08.009 · Cited by 16 · see citing works
Asthma Risk Among Individuals With Androgen Receptor Deficiency
Gaston, B. M., Marozkina, N. V., Newcomb, D. C., Sharifi, N., & Zein, J. (2021) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2021.0281 · Cited by 16 · see citing works
Higher premorbid serum testosterone predicts COVID-19-related mortality risk in men
Yeap, B. B., Marriott, R. J., Manning, L. A., Dwivedi, G., Hankey, G. J., Wu, F. C. W., Nicholson, J. K., & Murray, K. (2022) · European Journal of Endocrinology · doi:10.1530/eje-22-0104 · Cited by 14 · see citing works
Self-citationAssociation of testosterone therapy with disease progression in older males with COVID‐19
Baillargeon, J., Kuo, Y., Westra, J. R., López, D. S., Urban, R. J., Williams, S. B., & Raji, M. A. (2022) · Andrology · doi:10.1111/andr.13193 · Cited by 12 · see citing works
Sex matters: the frequently overlooked importance of considering sex in computational models
Burrowes, K., Ruppage, M., Lowry, A., & Zhao, D. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1186646 · Cited by 11 · see citing works
Endogenous inhibitory mechanisms in asthma
Chiarella, S. E., & Barnes, P. J. (2023) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2023.100135 · Cited by 12 · see citing works
Du, D., Bi, R., Xu, D., Liu, L., Hu, X., Zeng, T., Shen, Y., & Luo, F. (2024) · International Journal of COPD · doi:10.2147/copd.s463849 · Cited by 10 · see citing works
van der Plaat, D. A., Lenoir, A., Dharmage, S. C., Potts, J., Real, F. G., Shaheen, S. O., Jarvis, D., Minelli, C., & Leynaert, B. (2024) · Thorax · doi:10.1136/thorax-2023-220374 · Cited by 8 · see citing works
HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma
Zein, J., Gaston, B. M., Bazeley, P. S., DeBoer, M. D., Jr Igo, R. P., Bleecker, E. R., Meyers, D. A., Comhair, S. A. A., Marozkina, N. V., Cotton, C. U., et al. (2020) · Yearbook of pediatric endocrinology · doi:10.1530/ey.17.8.12 · Cited by 7 · see citing works
Parwanto, E. (2017) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20173535 · Cited by 6 · see citing works
Sex steroid hormones and asthma in males: a state-of-the-art review
Ermiş, S. S. Ö., Ercan, S., Malmhäll, C., Adesoba, H., Salisu, M., Bossios, A., Rådinger, M., Kankaanranta, H., & Nwaru, B. I. (2025) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2025.2501276 · Cited by 5 · see citing works
Liu, Y., Huang, C., Du, J., Lan, G., Du, X., Sun, Y., & Shi, G. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.915159 · Cited by 5 · see citing works
Kim, D. K., Park, J. J., Yang, W. J., Doo, S. W., & Kim, J. H. (2022) · Journal of Korean Medical Science · doi:10.3346/jkms.2022.37.e237 · Cited by 3 · see citing works
Huang, Y., Li, W., Sun, M., Duan, X., Wang, Y.-T., Zhang, L.-X., Xin, Z.-H., Yun, Z., Fan, B., & Li, X. (2022) · Asian Journal of Andrology · doi:10.4103/aja202246 · Cited by 4 · see citing works
Shorter Androgen Receptor PolyQ Alleles Protect Against Life-Threatening COVID-19 Disease in MalesPreprint
Baldassarri, M., Picchiotti, N., Fava, F., Fallerini, C., Benetti, E., Daga, S., Valentino, F., Doddato, G., Furini, S., Giliberti, A., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3692488 · Cited by 4 · see citing works
Androgens are a Key Factor Affecting Immune Related Diseases
Zou, H., Zhao, J., Xu, H., Chen, W., Cao, R., & Ma, Y. (2025) · The World Journal of Men s Health · doi:10.5534/wjmh.240292 · Cited by 2 · see citing works
Peripubertal changes in asthma
Silva, A. E., Ferrante, G., Silveyra, P., Čustović, A., Grutta, S. L., & Forno, E. (2026) · American Journal of Respiratory and Critical Care Medicine · doi:10.1093/ajrccm/aamag373 · Cited by 2 · see citing works
Association between sleep duration and lung function among U.S. adults
Li, J., Qian, X., Ding, G., & Zhang, Y. (2024) · BMC Public Health · doi:10.1186/s12889-024-21024-4 · Cited by 2 · see citing works
Kling, J. M., & Williams, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816569-0.00014-0 · Cited by 1 · see citing works
Testosterone Therapy and Diaphragm Performance in a Male Patient with COVID-19: A Case Report
Martins, G. A. R., Verdeal, J. C. R., Tostes, H., Silva, A. R. O., Tessarollo, B., Rocha, N. N., Rocco, P. R. M., & Silva, P. L. (2022) · Diagnostics · doi:10.3390/diagnostics12020535 · Cited by 1 · see citing works
Is it safe to delay testosterone replacement therapy in pandemic times?
Fácio, F. N., & Spessoto, L. C. F. (2020) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.66.s2.3
Hypothalamo–Pituitary–Testicular Axis Function in Systemic Diseases and Effects of Medications
Wittert, G., Yeap, B. B., & Grossmann, M. (2022) · doi:10.1093/med/9780198870197.003.0492
Self-citationEffect of Gender on Pulmonary Diseases
Aydın, A., & Yorgancıoğlu, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-22483-6_140-1
Genetic susceptibility to severe COVID-19 in men: The impact of androgen receptor CAG repeat length
Eskandarinezhad, A., Moradkhani, A., Azami, M., Shafiei, E., Hasani, S., Aghaei, A., Moradi, N., Ghafouri, S., Sigari, N., & Azarnezhad, A. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102299
Kling, J. M., & Williams, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-26712-3.00004-5
The testosterone paradox in asthma
Bossé, Y. (2026) · Frontiers in Allergy · doi:10.3389/falgy.2026.1740307
Hansen, E. S. H., Håkansson, K. E. J., Brustad, N., Meteran, H., Ascanius, P., McDonald, V. M., Juul, A., & Ulrik, C. S. (2026) · Respiratory Medicine · doi:10.1016/j.rmed.2026.108910
Randomized study of the effects of testosterone administration on severity of asthma in horses
Ruault, C., Mainguy‐Seers, S., Leduc, L., Juette, T., St‐Jean, G., & Lavoie, J. (2026) · Journal of Veterinary Internal Medicine · doi:10.1093/jvimsj/aalag187
- Authors
- Mohan, S. S., Knuiman, M. W., Divitini, M. L., James, A. L., Musk, A. W., Handelsman, D. J., Beilin, J., Hunter, M., & Yeap, B. B.
- Affiliations
- The University of Western Australia (AU)
- The University of Sydney (AU)
- Royal Perth Hospital (AU)
- Corresponding author
- Yeap, Bu B.
- Venue
- Clinical Endocrinology
- Publisher
- Wiley
- Published
- 2015-03-05
- Volume
- 83
- Issue
- 2
- Pages
- 268-276
- ISSN
- 0300-0664 (ISSN-L)
- 1365-2265
- OpenAlex
- W2103831745
- Cited by
- 61
- References
- 36
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 12 · 2021: 9 · 2020: 15 · 2019: 3 · 2018: 3 · 2017: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- National Health and Medical Research Council (1021326)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testosterone, dihydrotestosterone, estradiol, androgens, lung function, FEV1, forced vital capacity, community-dwelling men, smoking, FEV1/FVC ratio, older men
- MeSH terms
- Adult, Aged, Androgens, Asthma, Cardiovascular Diseases, Estradiol, Forced Expiratory Volume, Humans, Lung, Male, Middle Aged, Respiratory Function Tests, Risk Factors, Smoking, Mass Spectrometry, Spirometry, Dihydrotestosterone, Testosterone, Vital Capacity, Western Australia, Body Mass Index, Linear Models, Pulmonary Disease, Chronic Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
