Cited by 36Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsEndometriosis Research and Treatment

A randomized controlled trial of a lifestyle intervention with longitudinal follow‐up on ovarian dysmorphology in women with polycystic ovary syndrome

Kazemi, Maryam, Pierson, Roger A., McBreairty, Laura E., Chilibeck, Philip D., Zello, Gordon A., Chizen, Donna R.·2020·Clinical Endocrinology

Abstract

Objective: Effects of lifestyle modification on reproductive function in polycystic ovary syndrome (PCOS) remain poorly elucidated. We compared the effects of a pulse‐based diet (lentils, beans, split peas and chickpeas) with Therapeutic Lifestyle Changes (TLC) diet on ultrasonographic markers of ovarian morphology, hyperandrogenism and menstrual irregularity in PCOS. Design: Randomized controlled trial. Patients: Women with PCOS (18‐35 years). Measurements: Thirty women randomized to the pulse‐based and 31 to TLC groups completed a 16‐week intervention without energy restriction. Groups performed aerobic exercise (minimum of 5 days/wk; 45 minutes/d) and received health counselling (monthly) and longitudinal follow‐up. Follicle numbers per ovary (FNPO, 2‐9 mm), ovarian volume (OV), free androgen index (FAI) and menstrual cycle length were measured pre‐ and postintervention. Results: Follicle numbers per ovary (mean change ± SD, −10 ± 15), OV (−2.7 ± 4.8 mL), FAI (−3 ± 2) and menstrual cycle length (−13 ± 47 days) decreased over time in both groups (All: P < .01), without group‐by‐time interactions (All: P ≥ .13). Attrition rate was 33.7% and comparable between groups ( P = .94). Adherence to diet intervention negatively correlated with changes in FNPO (r=−0.54), OV (r=−0.35) and FAI ( r = −.29) in pooled groups (All: P ≤ .04). Groups maintained reduced OV, FNPO, FAI and menstrual cycles 6 months postintervention; however, decreased FNPO and FAI at 16 weeks tended to revert to baseline levels 12 months postintervention in both groups (All: P ≤ .05). Conclusions: Both interventions improved ovarian dysmorphology, hyperandrogenism and menstrual irregularity in PCOS, and no diet appeared to be superior at improving reproductive outcomes. Our observations highlight the importance of longitudinal surveillance for sustainable adherence to newly adopted healthy lifestyle behaviours and reproductive health in PCOS (ClinicalTrials.gov identifier, NCT01288638).

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Crossref · 10.1111/cen.14179

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  • Both low GI pulse-based and Therapeutic Lifestyle Changes interventions improved ovarian dysmorphology (follicle numbers per ovary, ovarian volume), hyperandrogenism, and menstrual irregularity in women with PCOS, with some benefits maintained 6 months postintervention.

    “Both interventions improved ovarian dysmorphology (follicle numbers per ovary, ovarian volume), hyperandrogenism, and menstrual irregularity, with some of the benefits maintained 6 months postintervention [31].”

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Authors
Kazemi, M., Pierson, R. A., McBreairty, L. E., Chilibeck, P. D., Zello, G. A., & Chizen, D. R.
Affiliations
University of Saskatchewan (CA)
Corresponding author
Chizen, Donna R.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2020-03-16
Volume
92
Issue
6
Pages
525-535
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
OpenAlex
W3008012589
Cited by
36
References
38
Citations by year
2026: 5 · 2025: 7 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 6
FWCI
5.07
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Saskatchewan Health Research Foundation
  • Saskatchewan Pulse Growers (G00014962 ‐ SPCD ‐ Effect of a Pulse‐Based Diet)
  • Canada Foundation for Innovation (29638)
  • Agriculture and Agri-Food Canada (G00011676)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords
polycystic ovary syndrome, lifestyle intervention, aerobic exercise, ovarian morphology, ovarian volume, free androgen index, hyperandrogenism, menstrual irregularity, dietary adherence, reproductive function, longitudinal follow-up
MeSH terms
Female, Follow-Up Studies, Humans, Life Style, Polycystic Ovary Syndrome, Hyperandrogenism

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