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Acromegaly management in the Nordic countries: A Delphi consensus survey

Arlien‐Søborg, Mai C., Dal, Jakob, Heck, Ansgar, Stochholm, Kirstine, Husted, Eigil, Feltoft, Claus Larsen, Rasmussen, Åse Krogh, Feldt‐Rasmussen, Ulla, Andreassen, Mikkel, Klose, Marianne Christina, Nielsen, Torben Leo, Andersen, Marianne Skovsager, Christensen, Louise Lehmann, Krogh, Jesper, Jarlov, Anne, Bollerslev, Jens, Nermoen, Ingrid, Oksnes, Marianne, Dahlqvist, Per, Olsson, Tommy, Berinder, Katarina, Hoybye, Charlotte, Petersson, Maria, Akerman, Anna‐karin, Wahlberg, Jeanette, Ekman, Bertil, Engstrom, Britt Eden, Johannsson, Gudmundur, Ragnarsson, Oskar, Olsson, Daniel, Sigurjónsdóttir, Helga Ágústa, Fougner, Stine Lyngvi, Matikainen, Niina, Vehkavaara, Satu, Metso, Saara, Jaatinen, Pia, Hämäläinen, Päivi, Rintamäki, Reeta, Yliaska, Iina, Immonen, Heidi, Mäkimattila, Sari, Cederberg‐Tamminen, Henna, Viukari, Marianna, Nevalainen, Pasi, Nuutila, Pirjo, Schalin‐Jäntti, Camilla, Burman, Pia, Jørgensen, Jens Otto Lunde·2024·Clinical Endocrinology
DOI 10.1111/cen.15095
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Abstract

Objective: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Several guidelines and recommendations on treatment algorithms and follow‐up exist. However, not all recommendations are strictly evidence‐based. To evaluate consensus on the treatment and follow‐up of patients with acromegaly in the Nordic countries. Methods: A Delphi process was used to map the landscape of acromegaly management in Denmark, Sweden, Norway, Finland, and Iceland. An expert panel developed 37 statements on the treatment and follow‐up of patients with acromegaly. Dedicated endocrinologists (n = 47) from the Nordic countries were invited to rate their extent of agreement with the statements, using a Likert‐type scale (1−7). Consensus was defined as ≥80% of panelists rating their agreement as ≥5 or ≤3 on the Likert‐type scale. Results: Consensus was reached in 41% (15/37) of the statements. Panelists agreed that pituitary surgery remains first line treatment. There was general agreement to recommend first‐generation somatostatin analog (SSA) treatment after failed surgery and to consider repeat surgery. In addition, there was agreement to recommend combination therapy with first‐generation SSA and pegvisomant as second‐ or third‐line treatment. In more than 50% of the statements, consensus was not achieved. Considerable disagreement existed regarding pegvisomant monotherapy, and treatment with pasireotide and dopamine agonists. Conclusion: This consensus exploration study on the management of patients with acromegaly in the Nordic countries revealed a relatively large degree of disagreement among experts, which mirrors the complexity of the disease and the shortage of evidence‐based data.

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Cited by 4

Research works printed but not linked: 44

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Metadata

Authors
Arlien‐Søborg, M. C., Dal, J., Heck, A., Stochholm, K., Husted, E., Feltoft, C. L., Rasmussen, Å. K., Feldt‐Rasmussen, U., Andreassen, M., Klose, M. C., Nielsen, T. L., Andersen, M. S., Christensen, L. L., Krogh, J., Jarlov, A., Bollerslev, J., Nermoen, I., Oksnes, M., Dahlqvist, P., Olsson, T., Berinder, K., Hoybye, C., Petersson, M., Akerman, A., Wahlberg, J., Ekman, B., Engstrom, B. E., Johannsson, G., Ragnarsson, O., Olsson, D., Sigurjónsdóttir, H. Á., Fougner, S. L., Matikainen, N., Vehkavaara, S., Metso, S., Jaatinen, P., Hämäläinen, P., Rintamäki, R., Yliaska, I., Immonen, H., Mäkimattila, S., Cederberg‐Tamminen, H., Viukari, M., Nevalainen, P., Nuutila, P., Schalin‐Jäntti, C., Burman, P., & Jørgensen, J. O. L.
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2024-06-12
Volume
101
Issue
3
Pages
263-273
ISSN
  • 0300-0664
  • 1365-2265
DOI
10.1111/cen.15095
Cited by
4
Language
en
Licence
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Funders
Pfizer

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CoChat. (2026). Citation check: Acromegaly management in the Nordic countries: A Delphi consensus survey. https://app.cochat.ai/papers/10.1111/cen.15095
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Arlien‐Søborg, M. C., Dal, J., Heck, A., Stochholm, K., Husted, E., Feltoft, C. L., Rasmussen, Å. K., Feldt‐Rasmussen, U., Andreassen, M., Klose, M. C., Nielsen, T. L., Andersen, M. S., Christensen, L. L., Krogh, J., Jarlov, A., Bollerslev, J., Nermoen, I., Oksnes, M., Dahlqvist, P., . . . Jørgensen, J. O. L. (2024). Acromegaly management in the Nordic countries: A Delphi consensus survey. Clinical Endocrinology. https://doi.org/10.1111/cen.15095

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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