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Molecular weaponry: diverse effectors delivered by the Type VI secretion system
Open accessAbstract
The Type VI secretion system is a widespread bacterial nanomachine, used to deliver toxins directly into eukaryotic or prokaryotic target cells. These secreted toxins, or effectors, act on diverse cellular targets, and their action provides the attacking bacterial cell with a significant fitness advantage, either against rival bacteria or eukaryotic host organisms. In this review, we discuss the delivery of diverse effectors by the Type VI secretion system, the modes of action of the so-called 'anti-bacterial' and 'anti-eukaryotic' effectors, the mechanism of self-resistance against anti-bacterial effectors and the evolutionary implications of horizontal transfer of Type VI secretion system-associated toxins. Whilst it is likely that many more effectors remain to be identified, it is already clear that toxins delivered by this secretion system represent efficient weapons against both bacteria and eukaryotes.
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Cites
Lery, L. M., Frangeul, L., Tomas, A., Passet, V., Almeida, A. S., Bialek-Davenet, S., Barbe, V., Bengoechea, J. A., Sansonetti, P., Brisse, S., et al. (2014) · BMC Biology · doi:10.1186/1741-7007-12-41 · Cited by 181
Cited by
Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P.-S., Taniki, N., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0333-1 · Cited by 425
The Type VI secretion system: a versatile bacterial weapon
Coulthurst, S. (2019) · Microbiology · doi:10.1099/mic.0.000789 · Cited by 346
Self-citationHayes, B. K., Harper, M., Venugopal, H., Lewis, J. M., Wright, A., Lee, H.-C., Steele, J. R., Steer, D. L., Schittenhelm, R. B., Boyce, J. D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52950-x · Cited by 15
Archaeal type six secretion system mediates contact-dependent antagonism
Zachs, T., Malit, J. J. L., Xu, J., Schürch, A., Sivabalasarma, S., Nußbaum, P., Albers, S.-V., & Pilhofer, M. (2024) · Science Advances · doi:10.1126/sciadv.adp7088 · Cited by 12
Metadata
- Authors
- Alcoforado Diniz, J., Liu, Y., & Coulthurst, S. J.
- Venue
- Cellular Microbiology
- Publisher
- Wiley
- Published
- 2015-11-03
- Volume
- 17
- Issue
- 12
- Pages
- 1742-1751
- ISSN
- 1462-5814 (ISSN-L)
- 1462-5822
- OpenAlex
- W1899329792
- Cited by
- 172
- References
- 1
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Alcoforado Diniz, J., Liu, Y., & Coulthurst, S. J. (2015). Molecular weaponry: diverse effectors delivered by the Type VI secretion system. Cellular Microbiology. https://doi.org/10.1111/cmi.12532
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