The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Nanopore sequencing: Review of potential applications in functional genomics
Abstract
Molecular biology has been led by various measurement technologies, and increased throughput has developed omics analysis. The development of massively parallel sequencing technology has enabled access to fundamental molecular data and revealed genomic and transcriptomic signatures. Nanopore sequencers have driven such evolution to the next stage. Oxford Nanopore Technologies Inc. provides a new type of single molecule sequencer using protein nanopore that realizes direct sequencing without DNA synthesizing or amplification. This nanopore sequencer can sequence an ultra‐long read limited by the input nucleotide length, or can determine DNA/RNA modifications. Recently, many fields such as medicine, epidemiology, ecology, and education have benefited from this technology. In this review, we explain the features and functions of the nanopore sequencer, introduce various situations where it has been used as a critical technology, and expected future applications.
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Cites
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Minimap2: Pairwise alignment for nucleotide sequences
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BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs
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Coming of age: ten years of next-generation sequencing technologies
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The sequence of sequencers: The history of sequencing DNA
Heather, J. M., & Chain, B. (2016) · Genomics · doi:10.1016/j.ygeno.2015.11.003 · Cited by 1,397 · cited 1×
“Latest in the line of DNA sequencers are the nanopore sequencers (Heather & Chain, 2016; Jain, Olsen, Paten, & Akeson, 2016; Mardis, 2013), successfully commercialized by Oxford Nanopore Technologies (ONT) (Brown & Clarke, 2016).”
MethodBulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files
Payne, A., Holmes, N., Rakyan, V., & Loose, M. (2019) · Bioinformatics · doi:10.1093/bioinformatics/bty841 · Cited by 326
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Mobile real-time surveillance of Zika virus in Brazil
Faria, N. R., Sabino, E. C., Nunes, M. R. T., Alcantara, L. C. J., Loman, N. J., & Pybus, O. G. (2016) · Genome Medicine · doi:10.1186/s13073-016-0356-2 · Cited by 195
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Chen, I.-M. A., Chu, K., Palaniappan, K., Ratner, A., Huang, J., Huntemann, M., Hajek, P., Ritter, S., Varghese, N., Seshadri, R., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa939 · Cited by 445
Multicomponent nature underlies the extraordinary mechanical properties of spider dragline silk
Kono, N., Nakamura, H., Mori, M., Yoshida, Y., Ohtoshi, R., Malay, A. D., Pedrazzoli Moran, D. A., Tomita, M., Numata, K., & Arakawa, K. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107065118 · Cited by 99
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Metadata
- Authors
- Kono, N., & Arakawa, K.
- Venue
- Development, Growth & Differentiation
- Publisher
- Wiley
- Published
- 2019-04-29
- Volume
- 61
- Issue
- 5
- Pages
- 316-326
- ISSN
- 0012-1592 (ISSN-L)
- 1440-169X
- OpenAlex
- W2942826041
- Cited by
- 313
- References
- 8
- FWCI
- 16.17
- Type
- journal article
- Language
- en
- Open access
- closed
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