The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Prognosis of the infected diabetic foot ulcer: a 12‐month prospective observational study
Open accessAbstract
Aims: To determine clinical outcomes and explore prognostic factors related to ulcer healing in people with a clinically infected diabetic foot ulcer. Methods: This multicentre, prospective, observational study reviewed participants’ data at 12 months after culture of a diabetic foot ulcer requiring antibiotic therapy. From participants’ notes, we obtained information on the incidence of wound healing, ulcer recurrence, lower extremity amputation, lower extremity revascularization and death. We estimated the cumulative incidence of healing at 6 and 12 months, adjusted for lower extremity amputation and death using a competing risk analysis, and explored the relationship between baseline factors and healing incidence. Results: In the first year after culture of the index ulcer, 45/299 participants (15.1%) had died. The ulcer had healed in 136 participants (45.5%), but recurred in 13 (9.6%). An ipsilateral lower extremity amputation was recorded in 52 (17.4%) and revascularization surgery in 18 participants (6.0%). Participants with an ulcer present for ~2 months or more had a lower incidence of healing (hazard ratio 0.55, 95% CI 0.39 to 0.77), as did those with a PEDIS (perfusion, extent, depth, infection, sensation) perfusion grade of ≥2 (hazard ratio 0.37, 95% CI 0.25 to 0.55). Participants with a single ulcer on their index foot had a higher incidence of healing than those with multiple ulcers (hazard ratio 1.90, 95% CI 1.18 to 3.06). Conclusions: Clinical outcomes at 12 months for people with an infected diabetic foot ulcer are generally poor. Our data confirm the adverse prognostic effect of limb ischaemia, longer ulcer duration and the presence of multiple ulcers.
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Cites
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A Proportional Hazards Model for the Subdistribution of a Competing Risk
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Statistical Analysis with Missing Data
Little, R. J. A., & Rubin, D. B. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/9781119013563 · Cited by 8,473
Preventing Foot Ulcers in Patients With Diabetes
Singh, N. (2005) · JAMA · doi:10.1001/jama.293.2.217 · Cited by 3,097
Lipsky, B. A., Berendt, A. R., Cornia, P. B., Pile, J. C., Peters, E. J. G., Armstrong, D. G., Deery, H. G., Embil, J. M., Joseph, W. S., Karchmer, A. W., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis346 · Cited by 1,766
Self-citationPrompers, L., Huijberts, M., Apelqvist, J., Jude, E., Piaggesi, A., Bakker, K., Edmonds, M., Holstein, P., Jirkovska, A., Mauricio, D., et al. (2007) · Diabetologia · doi:10.1007/s00125-006-0491-1 · Cited by 1,023
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Self-citationAmputation and Mortality in New-Onset Diabetic Foot Ulcers Stratified by Etiology
Moulik, P. K., Mtonga, R., & Gill, G. V. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.491 · Cited by 613
Neuropathic Diabetic Foot Ulcers
Boulton, A. J. M., Kirsner, R. S., & Vileikyte, L. (2004) · New England Journal of Medicine · doi:10.1056/nejmcp032966 · Cited by 592
Cited by
Diabetic Foot Ulcers: A Review
Armstrong, D. G., Tan, T.-W., Boulton, A. J. M., & Bus, S. A. (2023) · JAMA · doi:10.1001/jama.2023.10578 · Cited by 1,928
Senneville, É., Albalawi, Z., van Asten, S. A., Abbas, Z. G., Allison, G., Aragón‐Sánchez, J., Embil, J. M., Lavery, L. A., Alhasan, M., Oz, O., et al. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3687 · Cited by 498
Senneville, É., Albalawi, Z., van Asten, S. A., Abbas, Z. G., Allison, G., Aragón-Sánchez, J., Embil, J. M., Lavery, L. A., Alhasan, M., Oz, O., et al. (2023) · Clinical Infectious Diseases · doi:10.1093/cid/ciad527 · Cited by 192
Disparities in outcomes of patients admitted with diabetic foot infections.
Tan, T.-W., Shih, C.-D., Concha-Moore, K. C., Diri, M. M., Hu, B., Marrero, D., Zhou, W., & Armstrong, D. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211481 · Cited by 111
Classification of foot ulcers in people with diabetes: a systematic review.
Monteiro‐Soares, M., Hamilton, E. J., Russell, D. A., Srisawasdi, G., Boyko, E. J., Mills, J. L., Jeffcoate, W., & Game, F. (2024) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3645 · Cited by 59
Metadata
- Authors
- Ndosi, M., Wright‐Hughes, A., Brown, S., Backhouse, M., Lipsky, B. A., Bhogal, M., Reynolds, C., Vowden, P., Jude, E. B., Nixon, J., & Nelson, E. A.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2017-11-20
- Volume
- 35
- Issue
- 1
- Pages
- 78-88
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2766300169
- Cited by
- 287
- References
- 27
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ndosi, M., Wright‐Hughes, A., Brown, S., Backhouse, M., Lipsky, B. A., Bhogal, M., Reynolds, C., Vowden, P., Jude, E. B., Nixon, J., & Nelson, E. A. (2018). Prognosis of the infected diabetic foot ulcer: a 12‐month prospective observational study. Diabetic Medicine. https://doi.org/10.1111/dme.13537
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