Cited by 21Liver Disease Diagnosis and TreatmentDiabetes, Cardiovascular Risks, and LipoproteinsChronic Kidney Disease and Diabetes

Mechanisms, screening modalities and treatment options for individuals with non‐alcoholic fatty liver disease and type 2 diabetes

Hydes, T. J., Summers, N., Brown, E., Alam, U., Thomaides‐Brears, H., Wilding, J. P. H., Cuthbertson, D. J.·2020·Diabetic Medicine

Abstract

Non‐alcoholic fatty liver disease (NAFLD) exists as a spectrum of disease ranging from excessive accumulation of fat within the liver (simple steatosis), inflammation (non‐alcoholic steatohepatitis) through to fibrosis, cirrhosis and end‐stage liver disease. There is also an increased risk of hepatocellular carcinoma. The principal risk factor for NAFLD is overweight or obesity, along with type 2 diabetes, and NAFLD itself is also a risk factor for incident type 2 diabetes. Overweight/obesity is synergistic with alcohol consumption in causing progressive and insidious liver damage. Recent consensus advocates a change in nomenclature from NAFLD to ‘metabolic associated fatty liver disease’ (MAFLD), reflective of the associated metabolic abnormalities (insulin resistance/type 2 diabetes and metabolic syndrome components). Additional extra‐hepatic manifestations of NAFLD include cardiovascular disease, chronic kidney disease and certain cancers. Unlike other micro‐ and macrovascular complications of type 2 diabetes, systematic screening or surveillance protocols have not been widely adopted in routine diabetes care to assess for presence/severity of NAFLD. Various screening tools are available (non‐invasive tests and biochemical indices) combined with imaging techniques (e.g. transient elastography) to detect steatosis and more importantly advanced fibrosis/cirrhosis to facilitate appropriate surveillance. Liver biopsy may be sometimes necessary. Treatment options for type 2 diabetes, including lifestyle interventions (dietary change and physical activity), glucose‐lowering therapies and metabolic surgery, can modulate hepatic steatosis and to a lesser extent fibrosis. Awareness of the impact of liver disease on the choice of glucose‐lowering medications in individuals with type 2 diabetes is also critical.

Integrity signals

Registry

Crossref · 10.1111/dme.14356

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Once MASLD progresses beyond steatosis to steatohepatitis with fibrosis, there is substantial risk of cirrhosis, liver failure, and hepatocellular carcinoma.

    “Once MASLD progresses beyond steatosis to steatohepatitis with fibrosis, there is substantial risk of cirrhosis, liver failure, and hepatocellular carcinoma.124,125”

    From Definition and diagnostic criteria of clinical obesity (2025) · cites this paper as [125]

  • The presence of MASLD is associated with a higher risk of type 2 diabetes and cardiovascular disease.

    “The presence of MASLD is also associated with a higher risk of type 2 diabetes (and is present in ~70% of people with type 2 diabetes) and cardiovascular disease.125”

    From Definition and diagnostic criteria of clinical obesity (2025) · cites this paper as [125]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Hydes, T. J., Summers, N., Brown, E., Alam, U., Thomaides‐Brears, H., Wilding, J. P. H., & Cuthbertson, D. J.
Affiliations
  • University Hospital Southampton NHS Foundation Trust (GB)
  • Aintree University Hospitals NHS Foundation Trust (GB)
  • University of Liverpool (GB)
  • Perpsectum Gemini One Oxford UK
Corresponding author
Hydes, T. J.
Venue
Diabetic Medicine
Publisher
Wiley
Published
2020-07-13
Volume
37
Issue
11
Pages
1793-1806
ISSN
  • 0742-3071 (ISSN-L)
  • 1464-5491
OpenAlex
W3040248250
Cited by
21
References
50
Citations by year
2026: 4 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3
FWCI
0.33
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetic Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords
non-alcoholic fatty liver disease, type 2 diabetes, metabolic-associated fatty liver disease, NAFLD screening, liver fibrosis, liver cirrhosis, hepatocellular carcinoma, obesity, insulin resistance, metabolic syndrome, transient elastography, liver biopsy, glucose-lowering therapy, metabolic surgery, lifestyle intervention, cardiovascular risk, chronic kidney disease, extrahepatic manifestations
MeSH terms
Glucagon-Like Peptide-1 Receptor, Sodium-Glucose Transporter 2 Inhibitors, Glucagon-Like Peptide-1 Receptor Agonists, Alanine Transaminase, Aspartate Aminotransferases, Biopsy, Diabetes Mellitus, Type 2, Diet Therapy, gamma-Glutamyltransferase, Humans, Hypoglycemic Agents, Liver, Magnetic Resonance Imaging, Mass Screening, Obesity, Platelet Count, Risk Factors, Severity of Illness Index, Exercise, Metabolic Syndrome, Thiazolidinediones, Bariatric Surgery, Elasticity Imaging Techniques, Non-alcoholic Fatty Liver Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review