Cited by 128Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

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Pancreatic β-cell identity in diabetes

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Remedi, M. S., Emfinger, C.·2016·Diabetes, Obesity and Metabolism

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Abstract

Recovery of functional β‐cell mass continues to be an ongoing challenge in treating diabetes. Initial work studying β‐cells suggested apoptotic β‐cell death as a main contributor for the loss of β‐cell mass in diabetes. Restoration of β‐cells either by transplant or stimulating proliferation of remaining β‐cells or precursors would then logically be a viable therapeutic option for diabetes. However, recent work has highlighted the inherent β‐cell plasticity and the critical role of loss of β‐cell identity in diabetes, and has suggested that β‐cells fail to maintain a fully differentiated glucose‐responsive and drug‐responsive state, particularly in diabetic individuals with poorly controlled, long‐lasting periods of hyperglycaemia. Understanding the underlying mechanisms of loss of β‐cell identity and conversion in other cell types, as well as how to regain their mature differentiated functional state, is critical to develop novel therapeutic strategies to prevent or reverse these processes. In this review, we discuss the role of plasticity and loss of β‐cell identity in diabetes, the current understanding of mechanisms involved in altering this mature functional β‐cell state and potential progresses to identify novel therapeutic targets providing better opportunities for slowing or preventing diabetes progression.

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
(1998) · The Lancet · doi:10.1016/s0140-6736(98)07019-6 · Cited by 20,023
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.
Turner, R. C., Fox, C., Matthews, McElroy, H. H., Cull, C. A., Holman, R. R., Neil, P., Hadden, D. R., Wright, D., Manley, E., et al. (1998) · The Lancet · Cited by 8,419
Dietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children
Gupta, A., & Uribarri, J. (2016) · Hormone Research in Paediatrics · doi:10.1159/000444053 · Cited by 4,023
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
Kahn, S. E., Haffner, S. M., Heise, M. A., Herman, W. H., Holman, R. R., Jones, N. P., Kravitz, B. G., Lachin, J. M., O'Neill, M. C., Zinman, B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa066224 · Cited by 2,962
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Islet cell failure in type 2 diabetes
Prentki, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29103 · Cited by 1,690
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
Talchai, C., Xuan, S., Lin, H. V., Sussel, L., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.07.029 · Cited by 1,415
Glucolipotoxicity: fuel excess and β-cell dysfunction
Poitout, V., & Robertson, R. P. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0023 · Cited by 1,092
Type 2 diabetes across generations: from pathophysiology to prevention and management
Nolan, C. J., Damm, P., & Prentki, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60614-4 · Cited by 923
β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetesPreprint
Ahlgren, U., Jönsson, J., Jönsson, L., Simu, K., & Edlund, H. (1998) · Genes & Development · doi:10.1101/gad.12.12.1763 · Cited by 918
Type 2 Diabetes-a Matter of ß-Cell Life and Death?
Rhodes, C. J. (2005) · Science · doi:10.1126/science.1104345 · Cited by 903
Effect of intensive insulin therapy on β-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial
Weng, J., Li, Y., Xu, W., Shi, L., Zhang, Q., Zhu, D., Hu, Y., Zhou, Z., Yan, X., Tian, H., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60762-x · Cited by 780
Pancreatic β‐cell mass in European subjects with type 2 diabetes
Rahier, J., Guiot, Y., Goebbels, R. M., Sempoux, C., & Henquin, J. C. (2008) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00969.x · Cited by 756
β-Cell Failure in Diabetes and Preservation by Clinical Treatment
WAJCHENBERG, B. L. (2007) · Endocrine Reviews · doi:10.1210/10.1210/er.2006-0038 · Cited by 722
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients
Sakuraba, H., Mizukami, H., Yagihashi, N., Wada, R., Hanyu, C., & Yagihashi, S. (2002) · Diabetologia · doi:10.1007/s125-002-8248-z · Cited by 699
Recovery from diabetes in mice by β cell regeneration
Nir, T., Melton, D. A., & Dor, Y. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32959 · Cited by 595
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
Cinti, F., Bouchi, R., Kim-Muller, J. Y., Ohmura, Y., Sandoval, P. R., Masini, M., Marselli, L., Suleiman, M., Ratner, L. E., Marchetti, P., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2860 · Cited by 574
Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes
Jonas, J., Sharma, A., Hasenkamp, W. M., ILKOVA, H. M., Patanè, G., Laybutt, D. R., Bonner‐Weir, S., & Weir, G. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14112 · Cited by 567
cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2Preprint
Jhala, U. S., Canettieri, G., Screaton, R. A., Kulkarni, R., Krajewski, S., Reed, J. C., Walker, J. R., Lin, X., White, M. F., & Montminy, M. (2003) · Genes & Development · doi:10.1101/gad.1097103 · Cited by 557
Growth and Regeneration of Adult β Cells Does Not Involve Specialized Progenitors
Teta, M., Rankin, M. M., Long, S. Y., Stein, G. M., & Kushner, J. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.011 · Cited by 551
Inactivation of specific β cell transcription factors in type 2 diabetes
Guo, S., Dai, C., Guo, M., Taylor, B., Harmon, J. S., Sander, M., Robertson, R. P., Powers, A. C., & Stein, R. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65390 · Cited by 520
The Effect of Insulin Treatment on Insulin Secretion and Insulin Action in Type II Diabetes Mellitus
Garvey, W. T., Olefsky, J. M., Griffin, J., Hamman, R. F., & Kolterman, O. G. (1985) · Diabetes · doi:10.2337/diab.34.3.222 · Cited by 488
Calcineurin/NFAT signalling regulates pancreatic β-cell growth and function
Heit, J. J., Apelqvist, Å., Gu, X., Winslow, M. M., Neilson, J. R., Crabtree, G. R., & Kim, S. K. (2006) · Nature · doi:10.1038/nature05097 · Cited by 445
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
Butler, A. E., Cao-Minh, L., Galasso, R., Rizza, R. A., Corradin, A., Cobelli, C., & Butler, P. C. (2010) · Diabetologia · doi:10.1007/s00125-010-1809-6 · Cited by 435
Pancreatic β Cell Dedifferentiation in Diabetes and Redifferentiation following Insulin Therapy
Wang, Z., York, N., Nichols, C. G., & Remedi, M. S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.010 · Cited by 411
Self-citation
Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age
Rankin, M. M., & Kushner, J. A. (2009) · Diabetes · doi:10.2337/db08-1198 · Cited by 327
Control of Pancreatic β Cell Regeneration by Glucose Metabolism
Porat, S., Weinberg-Corem, N., Tornovsky-Babaey, S., Schyr, R. B., Hija, A., Stolovich-Rain, M., Dadon, D., Granot, Z., Ben-Hur, V., White, P., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.012 · Cited by 306
Combination therapies with insulin in type 2 diabetes
Yki-Järvinen, H. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.758 · Cited by 300
Islet β cell mass in diabetes and how it relates to function, birth, and death
Weir, G. C., & Bonner‐Weir, S. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12031 · Cited by 296
Life and Death of the Pancreatic β Cells
Bonner‐Weir, S. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00305-2 · Cited by 278
Induction of Long-Term Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients by Transient Intensive Insulin Treatment
Ilkova, H., Glaser, B., Tunçkale, A., Bagriaçik, N., & Cerasi, E. (1997) · Diabetes Care · doi:10.2337/diacare.20.9.1353 · Cited by 269
The replication of β cells in normal physiology, in disease and for therapy
Butler, P. C., Meier, J. J., Butler, A. E., & Bhushan, A. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0647 · Cited by 268
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose
Brereton, M. F., Iberl, M., Shimomura, K., Zhang, Q., Adriaenssens, A. E., Proks, P., Spiliotis, I. I., Dace, W., Mattis, K. K., Ramracheya, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5639 · Cited by 259
Relationship between β‐cell mass and diabetes onset
Matveyenko, A. V., & Butler, P. C. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00939.x · Cited by 249
Update of mutations in the genes encoding the pancreatic beta-cell KATPchannel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism
Flanagan, S. E., Clauin, S., Bellanné‐Chantelot, C., de Lonlay, P., Harries, L. W., Gloyn, A. L., & Ellard, S. (2008) · Human Mutation · doi:10.1002/humu.20838 · Cited by 246
Human β-Cell Proliferation and Intracellular Signaling
Kulkarni, R., Mizrachi, E.-B., Garcı́a-Ocaña, A., & Stewart, A. F. (2012) · Diabetes · doi:10.2337/db12-0018 · Cited by 243
Short-Term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes
Ryan, E. A., Imes, S., & Wallace, C. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1028 · Cited by 241
Restoration of Euglycemia and Normal Acute Insulin Response to Glucose in Obese Subjects With Type 2 Diabetes Following Bariatric Surgery
Polyzogopoulou, E., Kalfarentzos, F., Vagenakis, A. G., & Alexandrides, T. K. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1098 · Cited by 229
Diabetes mellitus—advances and challenges in human β-cell proliferation
Wang, P., Fiaschi‐Taesch, N., Vasavada, R. C., Scott, D. K., García-Ocaña, A., & Stewart, A. F. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.9 · Cited by 210
No evidence for β cell neogenesis in murine adult pancreas
Xiao, X., Chen, Z., Shiota, C., Prasadan, K. L., Guo, P., El‐Gohary, Y., Paredes, J. L., Welsh, C., Wiersch, J. C., & Gittes, G. K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66323 · Cited by 198
Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits
Spijker, H. S., Song, H., Ellenbroek, J. H., Roefs, M. M., Engelse, M. A., Bos, E., Koster, A. J., Rabelink, T. J., HANSEN, B. C., Clark, A., et al. (2015) · Diabetes · doi:10.2337/db14-1752 · Cited by 175
Beneficial Effects of Insulin on Glycemic Control and β-Cell Function in Newly Diagnosed Type 2 Diabetes With Severe Hyperglycemia After Short-Term Intensive Insulin Therapy
Chen, H.-S., Wu, T.-E., Jap, T., Hsiao, L.-C., Lee, S.-H., & Lin, H.-D. (2008) · Diabetes Care · doi:10.2337/dc08-0075 · Cited by 171
The role of aging upon β cell turnover
Kushner, J. A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64095 · Cited by 167
Cellular Plasticity within the Pancreas— Lessons Learned from Development
Puri, S., & Hebrok, M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.02.005 · Cited by 161
β-Cell Mass Dynamics and Islet Cell Plasticity in Human Type 2 Diabetes
Hanley, S. C., Austin, E. B., Assouline-Thomas, B., Kapeluto, J., Blaichman, J. I., Moosavi, M., Petropavlovskaia, M., & Rosenberg, L. C. (2010) · Endocrinology · doi:10.1210/en.2009-1277 · Cited by 160
Critical Reduction in β-Cell Mass Results in Two Distinct Outcomes over Time
Laybutt, D. R., Glandt, M., Xu, G., Ahn, Y. B., Trivedi, N., Bonner‐Weir, S., & Weir, G. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210581200 · Cited by 157
Effects of Bariatric Surgery on Glucose Homeostasis and Type 2 Diabetes
Bradley, D. P., Magkos, F., & Klein, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.114 · Cited by 154
Type 2 Diabetes, Insulin Secretion and β-Cell Mass
Ahren, B. (2005) · Current Molecular Medicine · doi:10.2174/1566524053766004 · Cited by 143
Lineage Tracing Evidence for In Vitro Dedifferentiation but Rare Proliferation of Mouse Pancreatic β-Cells
Weinberg-Corem, N., Ouziel-Yahalom, L., Knoller, S., Efrat, S., & Dor, Y. (2007) · Diabetes · doi:10.2337/db06-1654 · Cited by 140
Conversion of Mature Human β-Cells Into Glucagon-Producing α-Cells
Spijker, H. S., Ravelli, R. B. G., Mommaas, A. M., van Apeldoorn, A. A., Engelse, M. A., Zaldumbide, A., Bonner‐Weir, S., Rabelink, T. J., Hoeben, R. C., Clevers, H. C., et al. (2013) · Diabetes · doi:10.2337/db12-1001 · Cited by 138
Are we overestimating the loss of beta cells in type 2 diabetes?
Marselli, L., Suleiman, M., Masini, M., Campani, D., Bugliani, M., Syed, F., Martino, L., Focosi, D., Scatena, F., Olimpico, F., et al. (2014) · Diabetologia · doi:10.1007/s00125-013-3098-3 · Cited by 136
Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting
Jiao, Y., Le Lay, J., Yu, M., Naji, A., & Kaestner, K. H. (2014) · Diabetes · doi:10.2337/db13-1435 · Cited by 118
β-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of β-Cell Dedifferentiation and Degranulation
Butler, A. E., Dhawan, S., Hoang, J. D., Cory, M., Zeng, K., Fritsch, H., Meier, J. J., Rizza, R. A., & Butler, P. C. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3566 · Cited by 113
Impaired islet turnover in human donor pancreata with aging
Reers, C., Erbel, S., Esposito, I., Schmied, B., Büchler, M. W., Nawroth, P. P., & Ritzel, R. A. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0596 · Cited by 113
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
Dai, C., Kayton, N. S., Shostak, A., Poffenberger, G., Cyphert, H. A., Aramandla, R., Thompson, C., Papagiannis, I. G., Emfinger, C., Shiota, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83657 · Cited by 109
Self-citation
Clinical Evidence for the Earlier Initiation of Insulin Therapy in Type 2 Diabetes
Owens, D. R. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0081 · Cited by 108
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes
Girard, C. A., Wunderlich, F. T., Shimomura, K., Collins, S., Kaizik, S., Proks, P., Abdulkader, F., Clark, A., Ball, V., Zubcevic, L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35772 · Cited by 105
Regulated β-Cell Regeneration in the Adult Mouse Pancreas
Cano, D. A., Rulifson, I. C., Heiser, P. W., Swigart, L. B., Pelengaris, S., German, M. S., Evan, G. I., Bluestone, J. A., & Hebrok, M. (2007) · Diabetes · doi:10.2337/db07-0913 · Cited by 105
Secondary Consequences of β Cell Inexcitability: Identification and Prevention in a Murine Model of KATP-Induced Neonatal Diabetes Mellitus
Remedi, M. S., Kurata, H. T., Scott, A. C., Wunderlich, F. T., Rother, E., Kleinridders, A., Tong, A., Brüning, J. C., Koster, J. C., & Nichols, C. G. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.005 · Cited by 94
Self-citation
ß‐cell function and anti‐diabetic pharmacotherapy
Prato, S. D., Bianchi, C., & Marchetti, P. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.770 · Cited by 79
β-Cell failure in type 2 diabetes
Leibowitz, G., Kaiser, N., & Cerasi, E. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00094.x · Cited by 78
Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery
Arble, D. M., Sandoval, D. A., & Seeley, R. J. (2014) · Diabetologia · doi:10.1007/s00125-014-3433-3 · Cited by 74
Tolerance for ATP-Insensitive KATPChannels in Transgenic Mice
Koster, J. C., Knopp, A., Flagg, T. P., Markova, K., Sha, Q., Enkvetchakul, D., Betsuyaku, T., Yamada, K. A., & Nichols, C. G. (2001) · Circulation Research · doi:10.1161/hh2301.100342 · Cited by 71
Maintenance of β-Cell Maturity and Plasticity in the Adult Pancreas
Szabat, M., Lynn, F. C., Hoffman, B. G., Kieffer, T. J., Allan, D. W., & Johnson, J. D. (2012) · Diabetes · doi:10.2337/db11-1361 · Cited by 68
Interventions to Preserve Beta-Cell Function in the Management and Prevention of Type 2 Diabetes
Page, K. A., & Reisman, T. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0363-2 · Cited by 62
Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity
Burke, G. W., Vendrame, F., Virdi, S. K., Ciancio, G., Chen, L., Ruiz, P., Messinger, S., Reijonen, H., & Pugliese, A. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0691-5 · Cited by 62
Effects of insulin vs. glibenclamide in recently diagnosed patients with type 2 diabetes: a 4‐year follow‐up
Alvarsson, M., Sundkvist, G., Lager, I., Berntorp, K. E., Fernqvist‐Forbes, E., Steen, L., Örn, T., Holberg, M. A., Kirksæther, N., & Grill, V. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00719.x · Cited by 60
Death and Dysfunction of Transplanted β-Cells: Lessons Learned From Type 2 Diabetes?
Potter, K. J., Westwell-Roper, C. Y., Klimek-Abercrombie, A. M., Warnock, G. L., & Verchere, C. B. (2013) · Diabetes · doi:10.2337/db12-0364 · Cited by 59
Beta cells in type 2 diabetes – a crucial contribution to pathogenesis
Maedler, K. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00718.x · Cited by 53
Weighing up β-cell mass in mice and humans: Self-renewal, progenitors or stem cells?
Hanley, N. A., Hanley, K. P., Miettinen, P. J., & Otonkoski, T. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.03.001 · Cited by 37
The Effect of Early Insulin Therapy on Pancreatic β-Cell Function and Long-Term Glycemic Control in Newly Diagnosed Type 2 Diabetic Patients
Chon, S., Oh, S., Kim, S. W., Kim, J., Kim, Y. S., & Woo, J. (2010) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2010.25.3.273 · Cited by 30
Regulated and Reversible Induction of Adult Human β-Cell Replication
Takane, K. K., Kleinberger, J. W., Salim, F. G., Fiaschi‐Taesch, N., & Stewart, A. F. (2011) · Diabetes · doi:10.2337/db11-0580 · Cited by 25
Reduction of pancreatic β-cell dedifferentiation after gastric bypass surgery in diabetic rats
Qian, B., Zhou, X., Li, B., Li, B., Liu, Z., Wu, J., & Zhou, H. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju042 · Cited by 23
Experimental models of β-cell regeneration
Bonal, C., Avril, I., & Herrera, P. L. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360286 · Cited by 19
Betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans
Espes, D., Martinell, M., Liljebäck, H., & Carlsson, P. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0676-4 · Cited by 18
Restoration of sensitivity to sulfonylurea after strict glycaemic control with insulin in non-obese type 2 diabetic subjects.
Torella, R., Salvatore, T., Cozzolino, D., Giunta, R. E., Quatraro, A., & Giugliano, D. (1991) · PubMed · Cited by 13
Therapeutic Strategies to Increase Human β-Cell Growth and Proliferation by Regulating mTOR and GSK-3/β-Catenin Pathways
McDaniel, M. L. (2010) · The Open Endocrinology Journal · doi:10.2174/1874216501004010040 · Cited by 8
A 12-h intravenous insulin infusion restores the beta-cell response torpidity to sulfonylureas in patients affected by type 2 diabetes.
Sinagra, D., Greco, D., Amato, M. C., D’Acquisto, G., & Galluzzo, A. (2000) · Diabetes Care · doi:10.2337/diacare.23.12.1857 · Cited by 4

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Authors: Remedi, M. S., & Emfinger, C.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Remedi, M. S.
ORCID: Remedi, M. S.
Emfinger, C.
Venue: Diabetes, Obesity and Metabolism
Publisher: Wiley
Published: 2016-09
Volume: 18
Issue: S1
Pages: 110-116
ISSN: 1462-8902 (ISSN-L)
1463-1326
DOI: 10.1111/dom.12727
PMC: PMC5021188
OpenAlex: W2518974058
Cited by: 128
References: 80
Citations by year: 2026: 7 · 2025: 5 · 2024: 15 · 2023: 16 · 2022: 26 · 2021: 25 · 2020: 11 · 2019: 12 · 2018: 5 · 2017: 5 · 2016: 1
FWCI: 1.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 11 d)
Locations: Diabetes Obesity and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (R01 DK098584)
Diabetes Research Center (5P60 DK020579)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: beta cell plasticity, beta cell differentiation, beta-cell mass loss, beta-cell apoptosis, hyperglycemia, glucose responsiveness, drug response, diabetes treatment, beta cell regeneration
MeSH terms: Cell Plasticity, Insulin Secretion, Animals, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Insulin, Regeneration, Disease Progression, Cell Proliferation, Insulin-Secreting Cells, Mice, Cell Dedifferentiation, Cell Transdifferentiation

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Pancreatic β-cell identity in diabetes

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