Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients: Efficacy & complications of polynucleotide filler
Open accessAbstract
Aging well has become the new target of preventative medicine, and aesthetic dermatology can contribute to this request. The polynucleotide (PN) containing products not only fill the space, but improve tissue regeneration, resulting in more natural tissue regeneration. Five Korean women received four times injections of long-chain PN filler in two-week intervals for skin rejuvenation. About 0.05 mL of material was injected in 40 points of one-side cheek. The pore and skin thickness were markedly improved in the patients in their 30s, whereas skin tone, melanin, wrinkles, and sagging were noticeably improved for patients in their 40s. There are no serious side effects. In conclusion, intradermal long-chain PN filler injection seems to be an effective and safe treatment for skin rejuvenation.
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PN is derived from the testes of fishes such as salmon or trout.
“PN, derived from the testes of fishes such as salmon or trout, typically consists of relatively longer chains [21,22].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [22]
The Introduction says PN filler products are derived from the germ cells of salmon and other fish. It does not specify testes or name trout, so it supports the fish origin but not those details. (LLM, conf=0.85)
Experimental — accuracy not yet measuredPNs have high biocompatibility and biodegradability, favorable safety profiles, and low immunogenicity, making them suitable as facial fillers.
“Their high biocompatibility and biodegradability, accompanied by favorable safety profiles and low immunogenicity, also make them suitable as facial fillers [22,24,31,152,161,167].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [22]
The Discussion reports use of a PN filler for facial skin rejuvenation and concludes that it seems safe, based on five patients. It does not establish high biocompatibility, biodegradability, or low immunogenicity, or identify those properties as reasons PNs are suitable as facial fillers. (LLM, conf=0.88)
Experimental — accuracy not yet measured
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Cited by
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Kim, J. H., Kwon, T.-R., Lee, S. E., Jang, Y. N., Han, H. S., Mun, S. K., & Kim, B. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-61952-w · Cited by 53 · see citing works
Self-citationThe effectiveness of polynucleotides in esthetic medicine: a systematic review
Lampridou, S., Bassett, S., Cavallini, M., & Christopoulos, G. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16721 · Cited by 41 · see citing works
Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Park, K. Y., Seok, J., Rho, N. K., Kim, B. J., & Kim, M. N.
- Affiliations
- Chung-Ang University (KR)
- Leaders Aesthetic Laser and Cosmetic Surgery Center; Seoul Korea
- Corresponding author
- Kim, Beom Joon
- Venue
- Dermatologic Therapy
- Publisher
- Hindawi Limited
- Published
- 2015-11-02
- Volume
- 29
- Issue
- 1
- Pages
- 37-40
- ISSN
- 1396-0296 (ISSN-L)
- OpenAlex
- W1960246696
- Cited by
- 72
- References
- 0
- Citations by year
- 2026: 24 · 2025: 18 · 2024: 12 · 2023: 8 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dermatologic Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- skin rejuvenation, intradermal injection, facial aging, wrinkle reduction, skin thickness, tissue regeneration, cosmetic dermatology, treatment complications
- MeSH terms
- Dermal Fillers, Adult, Age Factors, Cosmetic Techniques, Esthetics, Female, Humans, Injections, Intradermal, Middle Aged, Polynucleotides, Rejuvenation, Skin, Time Factors, Skin Aging, Treatment Outcome, Patient Satisfaction
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