CoChat
Sign Up
Cited by 57Facial Rejuvenation and Surgery TechniquesDermatologic Treatments and ResearchPeriodontal Regeneration and Treatments

The effectiveness of polynucleotides in esthetic medicine: a systematic review

Open access
Lampridou, Smaragda, Bassett, Sian, Cavallini, Maurizio, Christopoulos, George·2025·Journal of Cosmetic Dermatology
DOI 10.1111/jocd.16721PMC PMC11845969
Open this paper in CoChat — free accountOpen PDF

Abstract

Background: Polynucleotides (PN), popular in biorevitalization, show promise in the current sphere of esthetic medicine due to their regenerative properties, previously used in wound healing. Currently, research investigates their use in esthetic medicine. The aim of this review was to synthesize the existing literature, focusing on the effectiveness of PN in esthetic medicine, which is concentrated on skin rejuvenation by providing patients with multiple benefits and the least side effects. Methods: A systematic electronic search was conducted in Embase, Medline, and Cochrane to identify primary research studies evaluating the effectiveness of polynucleotides in esthetic medicine, published in English between January 01, 2010, and January 01, 2024. A narrative synthesis was reported according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. The quality of evidence was assessed using the Critical Appraisal Skills Programme checklists. PROSPERO Registration: CRD42024588712. Results: Nine studies, of low and moderate quality, were included in this review, describing a population of 219 patients receiving PN treatment. A variation was present regarding procedural characteristics, such as injection areas and techniques. Polynucleotide injections have shown promising outcomes in reducing wrinkles, improving skin texture, and enhancing elasticity, with statistically significant results in several studies. While side effects are generally mild and transient, patient satisfaction is moderate to high, suggesting PN treatment as a well‐tolerated and effective cosmetic intervention. Conclusion: Polynucleotides offer promising potential in esthetic medicine; however, there is limited consensus regarding their optimal use. Rigorous, high‐quality studies are essential to validate the effectiveness and safety of PN.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/jocd.16721

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • These observations are consistent with contemporary literature describing nucleotide-based therapies as well tolerated across a range of dermatologic applications.

    “These observations are consistent with contemporary literature describing nucleotide-based therapies as well tolerated across a range of dermatologic applications [16,18].”

    From Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials (2026) · cites this paper as [16]

    The Results (Adverse Events) report no severe adverse events and generally mild, transient side effects; the Abstract (Results) describes PN treatment as well tolerated. But the review focuses on esthetic skin rejuvenation, so it does not establish tolerability across a broader range of dermatologic applications. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Recent reviews suggest that PN-based therapies function primarily as biostimulatory agents that improve tissue quality through progressive dermal remodeling rather than immediate structural correction.

    “Recent reviews similarly suggest that PN-based therapies function primarily as biostimulatory agents that improve tissue quality through progressive dermal remodeling rather than immediate structural correction [16,17].”

    From Polynucleotides and Polydeoxyribonucleotides for Skin Rejuvenation, Postoperative Scar Prevention, and Wound Healing: A Systematic Review of Randomized Clinical Trials (2026) · cites this paper as [16]

    The Conclusions describe PN as promoting collagen production and tissue repair, and the Discussion describes a lasting improvement in skin status rather than merely immediate hydration. The Results also report skin-texture improvements over weeks to months. The review does not establish the claim’s specific contrast with immediate structural correction. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • PN has exhibited excellent tolerability in both in vitro and in vivo models, with no notable side effects reported.

    “Similarly, PN has also exhibited excellent tolerability in both in vitro and in vivo models, with no notable side effects reported [149].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [149]

    The Results (Adverse Events) report no severe adverse events, but several studies reported mild effects such as pain, edema, and pruritus. The Materials and Methods (Eligibility Criteria) exclude animal and in vitro studies, so this review does not support the claim about tolerability in both in vitro and in vivo models. (LLM, conf=0.89)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

2 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Lampridou, S., Bassett, S., Cavallini, M., & Christopoulos, G.
Affiliations
  • Imperial College London (GB)
  • Sian Aesthetics, Highgate London UK
  • Centro Diagnostico Italiano (IT)
  • University of Ulster (GB)
Corresponding author
Lampridou, Smaragda
ORCID
Venue
Journal of Cosmetic Dermatology
Publisher
Wiley
Published
2024-12-08
Volume
24
Issue
2
Pages
e16721-e16721
ISSN
  • 1473-2130 (ISSN-L)
  • 1473-2165
DOI
10.1111/jocd.16721
PMC
PMC11845969
OpenAlex
W4405151257
Cited by
41
References
21
Citations by year
2026: 31 · 2025: 10
FWCI
3.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Cosmetic Dermatology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
polynucleotides, skin rejuvenation, wrinkle reduction, skin texture, skin elasticity, cosmetic injection, patient satisfaction, treatment safety
MeSH terms
Cosmetic Techniques, Esthetics, Humans, Polynucleotides, Rejuvenation, Skin, Skin Aging, Treatment Outcome, Patient Satisfaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review