The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Neuropsychiatric symptoms and quality of life in Spanish patients with Alzheimer’s disease during the COVID‐19 lockdown
Open accessAbstract
BACKGROUND AND PURPOSE: The COVID-19 epidemic is affecting almost all individuals worldwide, and patients with Alzheimer's disease (AD) and amnesic mild cognitive impairment (MCI) are particularly at risk due to their characteristics and age. We analysed the impact of the pandemic on these patients' neuropsychiatric symptoms and their quality of life after 5 weeks of lockdown in Spain. METHODS: A total of 40 patients with a diagnosis of MCI (n = 20) or mild AD (n = 20) from the Cognitive Stimulation Program of the Cognitive Disorders Unit were evaluated. All patients had undergone a previous evaluation during the month before the lockdown, and were re-evaluated after 5 weeks of lockdown. The Neuropsychiatric Inventory (NPI) and EuroQol-5D questionnaire (EQ-5D) were used to assess neuropsychiatric symptoms in patients and the quality of life in patients as well in caregivers. RESULTS: The mean (SD) total baseline NPI score was 33.75 (22.28), compared with 39.05 (27.96) after confinement (P = 0.028). The most frequently affected neuropsychiatric symptoms were apathy [4.15 (3.78) vs. 5.75 (4.02); P = 0.002] and anxiety [3.95 (3.73) vs. 5.30 (4.01); P = 0.006] in patients with MCI, and apathy [2.35 (2.70) vs. 3.75 (3.78); P = 0.036], agitation [0.45 (1.14) vs. 1.50 (2.66); P = 0.029] and aberrant motor behaviour [1.25 (2.86) vs. 2.00 (2.93); P = 0.044] in patients with AD. We did not observe differences in EQ-5D scores during the re-evaluation. The 30% of patients and 40% of caregivers reported a worsening of the patients' health status during confinement. CONCLUSIONS: The results of this study show the worsening of neuropsychiatric symptoms in patients with AD and MCI during 5 weeks of lockdown, with agitation, apathy and aberrant motor activity being the most affected symptoms.
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In the citing paper
“Lara et al. (26) observed that comparable changes, especially in apathy, occurred in both patients with mild cognitive impairment, and dementia due to AD.”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [26]
In the citing paper
“The majority of these studies included standardised tools to assess the presence and severity of neuropsychiatric symptoms, mostly the Neuropsychiatric Inventory (NPI) (23, 26, 27).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [26]
In the citing paper
“although changes in symptom severity were found to be similar between patients with mild cognitive impairment and dementia (26).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [26]
Citations
Cites
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Albert, M. S., DeKosky, S. T., Dickson, D., Dubois, B., Feldman, H. H., Fox, N. C., Gamst, A., Holtzman, D. M., Jagust, W. J., Petersen, R. C., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.008 · Cited by 10,152 · cited 12×
“The COVID epidemic is affecting individuals worldwide, and Alzheimer’s disease (AD) and amnesic mild cognitive impairment (MCI) patients are at risk due to their characteristics and age.”
MethodInfluentialThe Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · cited 1×
“The NPI concerns the severity and frequency of the following 12 domains of behavioural functioning: delusions, hallucinations, agitation/aggression, dysphoria, anxiety, euphoria, apathy, disinhibition, irritability/lability, aberrant motor activity, night-time behavioural disturbances, and appetite and eating abnormal…”
BackgroundOutbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle
Lu, H., Stratton, C. W., & Tang, Y. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25678 · Cited by 3,497
Ho, C. S., Chee, C. Y., & Ho, R. C. (2020) · Annals of the Academy of Medicine, Singapore · doi:10.47102/annals-acadmedsg.202043 · Cited by 1,699
Ho, C. S. H., Chee, C. Y., & Ho, R. (2020) · PubMed · Cited by 1,354
Troyer, E. A., Kohn, J. N., & Hong, S. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.04.027 · Cited by 964
COVID ‐19 and Older Adults: What We Know
Shahid, Z., Kalayanamitra, R., McClafferty, B., Kepko, D., Ramgobin, D., Patel, R. J., Aggarwal, C. S., Vunnam, R., Sahu, N., Bhatt, D., et al. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16472 · Cited by 958
Cited by
Sorted by citations
Assessment and characterisation of post‐COVID‐19 manifestations
Kamal, M., Abo Omirah, M., Hussein, A., & Saeed, H. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.13746 · Cited by 603
“finding after monitoring neuropsychiatric symptoms of Alzheimer's and mild cognitive impaired subjects whose were infected with the new coronavirus [18].”
BackgroundImpact of the COVID-19 Pandemic on Older Adults: Rapid Review
Lebrasseur, A., Fortin-Bédard, N., Lettre, J., Raymond, É., Bussières, È.-L., Lapierre, N., Faieta, J. M., Vincent, C., Duchesne, L., Ouellet, M., et al. (2021) · JMIR Aging · doi:10.2196/26474 · Cited by 445
Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia
Cagnin, A., Lorenzo, R. D., Marra, C., Bonanni, L., Cupidi, C., Laganà, V., Rubino, E., Vacca, A., Provero, P., Isella, V., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.578015 · Cited by 380
Psychological Health and Physical Activity Levels during the COVID-19 Pandemic: A Systematic Review
Violant, V., Jiménez, G. G., González, C. S. G., Muñoz‐Violant, S., Rodríguez, M. J., Sansano-Nadal, O., & Guerra-Balic, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249419 · Cited by 372
“For example, individuals with Alzheimer’s disease and mild cognitive impairments showed increased apathy, unusual motor activity, and agitation [42].”
BackgroundManca, R., De Marco, M., & Venneri, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.585540 · Cited by 227
Metadata
- Authors
- Lara, B., Carnes, A., Dakterzada, F., Benitez, I., & Piñol‐Ripoll, G.
- Affiliations
- Hospital Universitari de Santa Maria (ES)
- Hospital Universitari Arnau de Vilanova (ES)
- Corresponding author
- Piñol‐Ripoll, G.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2020-06-24
- Volume
- 27
- Issue
- 9
- Pages
- 1744-1747
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- PMC
- PMC7283827
- OpenAlex
- W3026319603
- Cited by
- 197
- References
- 12
- Citations by year
- 2025: 10 · 2024: 18 · 2023: 19 · 2022: 68 · 2021: 60 · 2020: 21
- FWCI
- 30.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositori ObertUDL (University of Lleida) (acceptedVersion)
- Funders
- Agència de Gestió d'Ajuts Universitaris i de Recerca (FI_B100153, SLT008/18)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Keywords
- Alzheimer's disease, amnestic mild cognitive impairment, neuropsychiatric symptoms, COVID-19 lockdown, quality of life, apathy, anxiety, agitation, caregiver burden, cognitive stimulation, Spain, EuroQol-5D, Neuropsychiatric Inventory, caregiver anxiety
- MeSH terms
- COVID-19, Aged, Aged, 80 and over, Alzheimer Disease, Anxiety, Female, Humans, Male, Neuropsychological Tests, Psychomotor Agitation, Quality of Life, Quarantine, Surveys and Questionnaires, Spain, Apathy, Pandemics
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