Dendritic ion channelopathy in acquired epilepsy
Open accessAbstract
Summary: Ion channel dysfunction or “channelopathy” is a proven cause of epilepsy in the relatively uncommon genetic epilepsies with Mendelian inheritance. But numerous examples of acquired channelopathy in experimental animal models of epilepsy following brain injury have also been demonstrated. Our understanding of channelopathy has grown due to advances in electrophysiology techniques that have allowed the study of ion channels in the dendrites of pyramidal neurons in cortex and hippocampus. The apical dendrites of pyramidal neurons comprise the vast majority of neuronal surface membrane area, and thus the majority of the neuronal ion channel population. Investigation of dendritic ion channels has demonstrated remarkable plasticity in ion channel localization and biophysical properties in epilepsy, many of which produce hyperexcitability and may contribute to the development and maintenance of the epileptic state. Herein we review recent advances in dendritic physiology and cell biology, and their relevance to epilepsy.
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In models of temporal lobe epilepsy there is a reduction in the expression of voltage-gated ion channels including Kv1.1.
“Consistent with these results, in models of temporal lobe epilepsy there is a reduction in the expression of voltage-gated ion channels including Kv1.1 (30,31,36).”
From Analysis of proteins that rapidly change upon mechanistic/mammalian target of rapamycin complex 1 (mTORC1) repression identifies parkinson protein 7 (PARK7) as a novel protein aberrantly expressed in tuberous sclerosis complex (TSC) (2016) · cites this paper as [36]
The A-type K+ channels section (page unavailable) reports reduced Kv4.2 expression in chronically epileptic rats, and the HCN channels section reports diminished HCN1 expression in acquired epilepsy models. These support the general point that ion-channel expression is reduced in such models, but our copy does not report a reduction in Kv1.1 expression. (LLM, conf=0.88)
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- Authors
- Poolos, N. P., & Johnston, D.
- Affiliations
- University of Washington (US)
- The University of Texas at Austin (US)
- Corresponding author
- Poolos, Nicholas P.
- Venue
- Epilepsia
- Publisher
- Wiley
- Published
- 2012-12
- Volume
- 53
- Issue
- s9
- Pages
- 32-40
- ISSN
- 0013-9580 (ISSN-L)
- 1528-1167
- PMC
- PMC3531827
- OpenAlex
- W2138971707
- Cited by
- 75
- References
- 5
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 22 · 2022: 4 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 8 · 2014: 6 · 2013: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epilepsia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (MH048432, NS050229)
- National Institute of Mental Health (MH048432, R01MH094839, R01MH048432, MH-094839)
- National Institute of Neurological Disorders and Stroke (R21NS077477, NS050229, R01NS050229, R56NS050229, NS077477)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dendritic ion channels, acquired epilepsy, channelopathies, pyramidal neurons, dendritic plasticity, neuronal hyperexcitability, hippocampus, cerebral cortex, brain injury
- MeSH terms
- Animals, Dendrites, Epilepsy, Humans, Ion Channels, Potassium Channels, Pyramidal Cells, Calcium Channels, T-Type, Channelopathies, Cyclic Nucleotide-Gated Cation Channels, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
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