Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons
Abstract
Most mammalian central neurons receive synaptic input over complicated dendritic arbors. Therefore, timing of synaptic information should vary with synapse location. However, I report that temporal summation at CA1 pyramidal somata does not depend on the location of synaptic input. This spatial normalization of temporal integration requires a dendritic hyperpolarization-activated current (lh). Shaping of synaptic activity by deactivating a nonuniform lh could counterbalance filtering by dendrites and effectively remove location-dependent variability in temporal integration, thus enhancing synchronization of neuronal populations and functional capabilities of the hippocampal CA1 region.
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Distal EPSPs in CA1 neurons are locally attenuated by active properties of dendrites, including high density of HCN1 channels in distal dendrites.
“Second, distal EPSPs in CA1 neurons are locally attenuated by the active properties of the dendrites, including the presence of a very high density of HCN1 channels in the distal dendrites, which act as a depolarizing shunt conductance (George et al., 2009; Magee, 1999).”
From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Magee, 1999
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- Authors
- Magee, J. C.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Magee, Jeffrey C.
- ORCID
- Magee, Jeffrey C.
- Venue
- Nature Neuroscience
- Published
- 1999-06
- Volume
- 2
- Issue
- 6
- Pages
- 508-514
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- DOI
- 10.1038/9158
- OpenAlex
- W2020505352
- Cited by
- 617
- References
- 30
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 18 · 2023: 14 · 2022: 19 · 2021: 21 · 2020: 26 · 2019: 14 · 2018: 26 · 2017: 15 · 2016: 22 · 2015: 31 · 2014: 18 · 2013: 33 · 2012: 29
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Update notices
- erratum (1999-09-01)
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS35865)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- hyperpolarization-activated current, dendritic integration, temporal summation, CA1 pyramidal neurons, neuronal synchronization
- MeSH terms
- Animals, Dendrites, Electric Conductivity, Electric Stimulation, Hippocampus, Neurons, Synapses, Time Factors, Rats, Sprague-Dawley, Excitatory Postsynaptic Potentials, Rats
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