The DOI matches its Crossref record; 193 of the 193 references it cites were found in a registry or an index.
Components and regulation of nuclear transport processes
Open accessAbstract
The spatial separation of DNA replication and gene transcription in the nucleus and protein translation in the cytoplasm is a uniform principle of eukaryotic cells. This compartmentalization imposes a requirement for a transport network of macromolecules to shuttle these components in and out of the nucleus. This nucleo‐cytoplasmic transport of macromolecules is critical for both cell physiology and pathology. Consequently, investigating its regulation and disease‐associated alterations can reveal novel therapeutic approaches to fight human diseases, such as cancer or viral infection. The characterization of the nuclear pore complex, the identification of transport signals and transport receptors, as well as the characterization of the Ran system (providing the energy source for efficient cargo transport) has greatly facilitated our understanding of the components, mechanisms and regulation of the nucleo‐cytoplasmic transport of proteins in our cells. Here we review this knowledge with a specific emphasis on the selection of disease‐relevant molecular targets for potential therapeutic intervention.
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Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
Yi, R., Qin, Y., Macara, I. G., & Cullen, B. R. (2003) · Genes & Development · doi:10.1101/gad.1158803 · Cited by 3,010
Nuclear Export of MicroRNA Precursors
Lund, E., Güttinger, S., Calado, A., Dahlberg, J. E., & Kutay, U. (2004) · Science · doi:10.1126/science.1090599 · Cited by 2,714
A short amino acid sequence able to specify nuclear location
Kalderon, D., Roberts, B. L., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,507
CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals
Fornerod, M., Ohno, M., Yoshida, M., & Mattaj, I. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80371-2 · Cited by 2,081
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
BOHNSACK, M. T., CZAPLINSKI, K., & GÖRLICH, D. (2004) · RNA · doi:10.1261/rna.5167604 · Cited by 1,433
The Yeast Nuclear Pore Complex
Rout, M. P., Aitchison, J. D., Suprapto, A., Hjertaas, K., Zhao, Y., & Chait, B. T. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.635 · Cited by 1,400
Regulation of JAK–STAT signalling in the immune system
Shuai, K., & Liu, B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1226 · Cited by 1,372
Sequence requirements for nuclear location of simian virus 40 large-T antigen
Kalderon, D., Richardson, W. D., Markham, A. F., & Smith, A. E. (1984) · Nature · doi:10.1038/311033a0 · Cited by 1,286
Malim, M. H., Hauber, J., Le, S.-Y., Maizel, J. V., & Cullen, B. R. (1989) · Nature · doi:10.1038/338254a0 · Cited by 1,280
Cited by
Types of nuclear localization signals and mechanisms of protein import into the nucleus
Lu, J., Wu, T., Zhang, B., Liu, S., Song, W., Qiao, J., & Ruan, H. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00741-y · Cited by 459
Wong, R. W., Mamede, J. I., & Hope, T. J. (2015) · Journal of Virology · doi:10.1128/jvi.01669-15 · Cited by 45
Disruption of nucleocytoplasmic trafficking as a cellular senescence driver.
Park, J.-H., Ryu, S. J., Kim, B. J., Cho, H.-J., Park, C. H., Choi, H. J. C., Jang, E.-J., Yang, E. J., Hwang, J.-A., Woo, S.-H., et al. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00643-6 · Cited by 44
Metadata
- Authors
- Cautain, B., Hill, R., de Pedro, N., & Link, W.
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2014-12-22
- Volume
- 282
- Issue
- 3
- Pages
- 445-462
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W2066239225
- Cited by
- 272
- References
- 193
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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