The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
Open accessAbstract
MicroRNAs (miRNAs) are initially expressed as long transcripts that are processed in the nucleus to yield ∼65-nucleotide (nt) RNA hairpin intermediates, termed pre-miRNAs, that are exported to the cytoplasm for additional processing to yield mature, ∼22-nt miRNAs. Here, we demonstrate that human pre-miRNA nuclear export, and miRNA function, are dependent on Exportin-5. Exportin-5 can bind pre-miRNAs specifically in vitro, but only in the presence of the Ran-GTP cofactor. Short hairpin RNAs, artificial pre-miRNA analogs used to express small interfering RNAs, also depend on Exportin-5 for nuclear export. Together, these findings define an additional cellular cofactor required for miRNA biogenesis and function.
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The microRNAs of Caenorhabditis elegans
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miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
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Cited by
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
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Metadata
- Authors
- Yi, R., Qin, Y., Macara, I. G., & Cullen, B. R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-01-01
- Volume
- 17
- Issue
- 24
- Pages
- 3011-3016
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2014064723
- Cited by
- 3,010
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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