Role of mitochondria in renal ischemia-reperfusion injury
Open accessAbstract
Acute kidney injury (AKI) induced by renal ischemia–reperfusion injury (IRI) has a high morbidity and mortality, representing a worldwide problem. The kidney is an essential organ of metabolism that has high blood perfusion and is the second most mitochondria‐rich organ after the heart because of the high ATP demands of its essential functions of nutrient reabsorption, acid–base and electrolyte balance, and hemodynamics. Thus, these energy‐intensive cells are particularly vulnerable to mitochondrial dysfunction. As the bulk of glomerular ultrafiltrate reabsorption by proximal tubules occurs via active transport, the mitochondria of proximal tubules must be equipped for detecting and responding to fluctuations in energy availability to guarantee efficient basal metabolism. Any insults to mitochondrial quality control mechanisms may lead to biological disruption, blocking the clearance of damaged mitochondria and resulting in morphological change and tissue dysfunction. Extensive research has shown that mitochondria have pivotal roles in acute kidney disease, so in this article, we discuss the role of mitochondria, their dynamics and mitophagy in renal ischemia–reperfusion injury.
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Upon reperfusion, abrupt reoxygenation triggers a burst of mitochondrial superoxide production and a transient increase in tissue ROS.
“Upon reperfusion, abrupt reoxygenation triggers a burst of mitochondrial superoxide production and a transient increase in tissue ROS”
From Material-dependent oxygen transport governs ischemia-reperfusion injury and drug response in a kidney microphysiological system (2026) · cites this paper as Huang et al., 2024
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Kutsuzawa, N., Nakamura, H., Shinha, K., & Kimura, H. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1854389
- Authors
- Huang, R., Zhang, C., Xiang, Z., Lin, T., Ling, J., & Hu, H.
- Affiliations
- Second Affiliated Hospital of Nanchang University (CN)
- Corresponding author
- Hu, Honglin
- Venue
- The FEBS Journal
- Publisher
- Wiley
- Published
- 2024-04-03
- Volume
- 291
- Issue
- 24
- Pages
- 5365-5378
- ISSN
- 1742-464X (ISSN-L)
- 1742-4658
- OpenAlex
- W4393856043
- Cited by
- 72
- References
- 10
- Citations by year
- 2026: 35 · 2025: 32 · 2024: 5
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- FEBS Journal (publishedVersion)
- SSRN Electronic Journal (acceptedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondria, renal ischemia-reperfusion injury, acute kidney injury, mitochondrial dysfunction, mitophagy, mitochondrial dynamics, proximal tubule, mitochondrial quality control, energy metabolism
- MeSH terms
- Animals, Humans, Kidney, Mitochondria, Reperfusion Injury, Acute Kidney Injury, Mitophagy
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