Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling
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Genetic targeting experiments indicate a fundamental role for mitochondrial fusion proteins in mammalian physiology. However, owing to the multiple functions of fusion proteins, their related phenotypes are not necessarily caused by altered mitochondrial fusion. Perhaps the biggest mystery is presented by skeletal muscle, where mostly globular-shaped mitochondria are densely packed into the narrow intermyofilamental space, limiting the interorganellar interactions. We show here that mitochondria form local networks and regularly undergo fusion events to share matrix content in skeletal muscle fibers. However, fusion events are less frequent and more stable in the fibers than in nondifferentiated myoblasts. Complementation among muscle mitochondria was suppressed by both in vivo genetic perturbations and chronic alcohol consumption that cause myopathy. An Mfn1-dependent pathway is revealed whereby fusion inhibition weakens the metabolic reserve of mitochondria to cause dysregulation of calcium oscillations during prolonged stimulation. Thus, fusion dynamically connects skeletal muscle mitochondria and its prolonged loss jeopardizes bioenergetics and excitation–contraction coupling, providing a potential pathomechanism contributing to myopathies.
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Mitochondrial fusion enables redistribution of energy in the form of mitochondrial potential, metabolites, proteins, and mtDNA, improving calcium handling and ATP synthesis.
“This process enables the redistribution of energy in the form of mitochondrial potential, metabolites, proteins, and mtDNA, improving calcium handling, and ATP synthesis [24, 54–57].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [54]
Mitochondrial fusion in skeletal muscle is necessary to adapt to the cell's specific functional needs and support skeletal muscle myofiber contractile function.
“mitochondrial fusion in skeletal muscle is necessary to adapt to the cell's specific functional needs and support skeletal muscle myofibers contractile function [54].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [54]
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- Authors
- Eisner, V., Lenaers, G., & Hajnóczky, G.
- Affiliations
- Thomas Jefferson University (US)
- Inserm (FR)
- Corresponding author
- Hajnóczky, György
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2014-04-21
- Volume
- 205
- Issue
- 2
- Pages
- 179-195
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- PMC
- PMC4003250
- OpenAlex
- W2007546912
- Cited by
- 177
- References
- 74
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 16 · 2023: 11 · 2022: 20 · 2021: 21 · 2020: 19 · 2019: 10 · 2018: 12 · 2017: 17 · 2016: 16 · 2015: 14 · 2014: 2
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Cell Biology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Duchenne Parent Project
- National Institutes of Health
- Hospital Universiti Sains Malaysia
- National Institute on Alcohol Abuse and Alcoholism (R01AA017773, U01AA021122, AA017773, RC2AA019416)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK051526)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial fusion, skeletal muscle, excitation-contraction coupling, Mfn1, mitochondrial network, myoblasts, chronic alcohol consumption, myopathy, calcium oscillations
- MeSH terms
- Animals, Cell Line, Female, Humans, Male, Membrane Proteins, Mitochondria, Muscle, Muscle Contraction, Muscle, Skeletal, Calcium Signaling, GTP Phosphohydrolases, Mitochondrial Proteins, Mitochondrial Membrane Transport Proteins, Mice, Rats, Mitochondrial Dynamics
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