Diet impact on mitochondrial bioenergetics and dynamics
Open accessAbstract
Diet induced obesity is associated with impaired mitochondrial function and dynamic behavior. Mitochondria are highly dynamic organelles and the balance in fusion/fission is strictly associated with their bioenergetics. Fusion processes are associated with the optimization of mitochondrial function, whereas fission processes are associated with the removal of damaged mitochondria. In diet-induced obesity, impaired mitochondrial function and increased fission processes were found in liver and skeletal muscle. Diverse dietary fat sources differently affect mitochondrial dynamics and bioenergetics. In contrast to saturated fatty acids, omega 3 polyunsaturated fatty acids induce fusion processes and improve mitochondrial function. Moreover, the pro-longevity effect of caloric restriction has been correlated with changes in mitochondrial dynamics leading to decreased cell oxidative injury. Noteworthy, emerging findings revealed an important role for mitochondrial dynamics within neuronal populations involved in central regulation of body energy balance. In conclusion, mitochondrial dynamic processes with their strict interconnection with mitochondrial bioenergetics are involved in energy balance and diet impact on metabolic tissues.
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Mitochondrial dysfunction plays an important role in obesity and obesity-related diseases such as insulin resistance and fatty liver.
“A considerable body of evidence demonstrate that mitochondrial dysfunction also plays an important role in obesity and obesity-related diseases such as insulin resistance and fatty liver.”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Putti et al., 2015
Impaired mitochondrial function and dynamics are associated with diet-induced obesity, mainly affecting liver and skeletal muscle.
“Impaired mitochondrial function and dynamics have been associated with diet induced obesity mainly affecting liver and skeletal muscle (Putti et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Putti et al., 2015
Mitochondrial dysfunctions in diet-induced obesity are modulated by caloric restriction and exercise.
“These dysfunctions have been modulated by CR and exercise (Putti et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Putti et al., 2015
Impaired mitochondrial function and dynamics have been associated with diet induced obesity mainly affecting liver and skeletal muscle.
“Impaired mitochondrial function and dynamics have been associated with diet induced obesity mainly affecting liver and skeletal muscle (Putti et al., 2015).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Putti et al., 2015
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- Authors
- Putti, R., Sica, R., Migliaccio, V., & Lionetti, L.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Lionetti, Lillà
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2015-04-08
- Volume
- 6
- Pages
- 109-109
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC4389347
- OpenAlex
- W2114167392
- Cited by
- 192
- References
- 58
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 20 · 2023: 17 · 2022: 18 · 2021: 19 · 2020: 31 · 2019: 31 · 2018: 14 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- diet-induced obesity, mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, mitochondrial bioenergetics, omega-3 polyunsaturated fatty acids, dietary fat, saturated fatty acids, caloric restriction, longevity, oxidative stress, energy balance, liver, skeletal muscle, neurons
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