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Circulating irisin levels as a predictive biomarker for sarcopenia: a cross-sectional community-based study
Open accessAbstract
Aim: Myokines are peptides released by the skeletal muscle, and have gained popularity as potential biomarkers for sarcopenia. Irisin is a recently identified myokine, but its role in pathological sarcopenia remains unclear. We investigated the validity and accuracy of circulating irisin levels as a potential biomarker for sarcopenia. Methods: We evaluated the anthropometrics, body composition, sarcopenia‐related parameters and serum irisin levels of 715 community‐dwelling Koreans. Sarcopenia was determined on the basis of the clinical diagnostic criteria of muscle atrophy and weakness, which were proposed by the Asian Working Group for Sarcopenia. Results: Circulating irisin levels were correlated with appendicular lean mass/height 2 (rmen = 0.275; rwomen = 0.321) and handgrip strength (rmen = 0.219; rwomen = 0.312) in both sexes (all P < 0.01). Furthermore, the mean circulating irisin levels were lower in the sarcopenia group than in the normal group (all P < 0.05). In the logistic regression models, the association between serum irisin concentration and incident sarcopenia persisted even after adjusting for potential confounders, such as sex, age and fat indices (odds ratio 0.20, 95% CI 0.07–0.60; P for trend <0.01). The predictive values of serum irisin for sarcopenia were <1.0 μg/mL in men and <1.16 μg/mL in women, with the area under the receiver operating characteristic curves of 0.87 (95% CI 0.77–0.99) and 0.68 (95% CI 0.55–0.81), respectively (all P < 0.01). Conclusions: A low level of circulating irisin is a sensitive marker for muscle weakness and atrophy. Irisin is a potential biomarker for muscle dysfunction that could help predict the onset of sarcopenia and provide new avenues for monitoring age‐related muscle changes. Geriatr Gerontol Int 2017; 17: 2266–2273.
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“However, several studies have documented that the content of myostatin is upregulated while irisin is downregulated in sarcopenia (44).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [44]
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“Production of myostatin, a growth-inhibiting myokine, is upregulated in sarcopenia64, whereas that of muscle-mass-stimulating irisin seems to be downregulated65.”
From Sarcopenic obesity in older adults: a clinical overview (2024) · cites this paper as [65]
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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
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Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909
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FNDC5/irisin is not only a myokine but also an adipokine
Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612
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Cited by
Sorted by citations
Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment
Chen, L.-K., Woo, J., Assantachai, P., Auyeung, T.-W., Chou, M.-Y., Iijima, K., Jang, H. C., Kang, L., Kim, M., Kim, S., et al. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.12.012 · Cited by 7,070
Cardoso, A. L., Fernandes, A. M. A., Aguilar‐Pimentel, J. A., de Angelis, M. H., Guedes, J. R., Brito, M. A., Ortolano, S., Pani, G., Athanasopoulou, S., Gonos, E. S., et al. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.004 · Cited by 483
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Sarcopenic obesity in older adults: a clinical overview
Prado, C. M., Batsis, J. A., Donini, L. M., Gonzalez, M. C., & Siervo, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00943-z · Cited by 355
Irisin: A Hope in Understanding and Managing Obesity and Metabolic Syndrome
Arhire, L. I., Mihalache, L., & Covașă, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00524 · Cited by 317
Metadata
- Authors
- Chang, J. S., Kim, T. H., Nguyen, T. T., Park, K., Kim, N., & Kong, I. D.
- Affiliations
- Yonsei University (KR)
- Department of Physiology Tan Tao University College of Medicine Long An Vietnam
- Keimyung University (KR)
- Corresponding author
- Kong, In Deok
- Venue
- Geriatrics & Gerontology International
- Publisher
- Wiley
- Published
- 2017-04-10
- Volume
- 17
- Issue
- 11
- Pages
- 2266-2273
- ISSN
- 1444-1586 (ISSN-L)
- 1447-0594
- OpenAlex
- W2606294901
- Cited by
- 166
- References
- 33
- Citations by year
- 2026: 16 · 2025: 30 · 2024: 15 · 2023: 27 · 2022: 29 · 2021: 15 · 2020: 14 · 2019: 9 · 2018: 7 · 2017: 4
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Geriatrics and gerontology international/Geriatrics & gerontology international (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- KUMeL Repository (Keimyung University) (submittedVersion, cc-by-nc-nd)
- Funders
- Research Grants, Yonsei University Wonju College of Medicine (YUWCM-2013-24)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- irisin, sarcopenia, myokines, serum biomarkers, muscle weakness, muscle atrophy, Asian Working Group for Sarcopenia criteria, community-dwelling older adults, age-related muscle loss, predictive value
- MeSH terms
- Cross-Sectional Studies, Female, Fibronectins, Humans, Male, Predictive Value of Tests, Biomarkers, Sarcopenia
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