Platelet‐to‐lymphocyte ratio better predicts inflammation than neutrophil‐to‐lymphocyte ratio in end‐stage renal disease patients
Abstract
Neutrophil‐to‐lymphocyte ratio ( NLR ) was introduced as a potential marker to determine inflammation in end‐stage renal disease ( ESRD ) patients. Recently, platelet‐to‐lymphocyte ratio ( PLR ) and NLR were found to positively correlated with inflammatory markers including tumor necrosis factor‐α ( TNF ‐α) and interleukin ( IL )‐6 in cardiac and noncardiac patients. Data regarding PLR and its association with inflammation are lacking in hemodialysis ( HD ) and peritoneal dialysis ( PD ) patients. Hence, we aimed to determine the relationship between PLR , NLR , and inflammation in ESRD patients. This was a cross‐sectional study involving 62 ESRD patients (29 females, 33 males; mean age, 49.6 ± 14.6 years) receiving PD or HD for ≥6 months in the D ialysis U nit of N ecmettin E rbakan U niversity. PLR , NLR , C ‐reactive protein, TNF ‐α, IL ‐6 levels were measured. PLR , NLR , serum high sensitive C ‐reactive protein, IL ‐6, and TNF ‐α levels were significantly higher in PD patients when compared with HD patients. ESRD patients with PLR ≥ 140 had significantly higher NLR , IL ‐6, and TNF ‐α levels when compared to patients with PLR < 139. In the bivariate correlation analysis, PLR was positively correlated with NLR , IL ‐6, and TNF ‐α in this population. When we compared the association of PLR and NLR with IL ‐6 (r = 0.371, P = 0.003 vs. r = 0.263, P = 0.04, respectively) and TNF ‐α (r = 0.334, P = 0.008 vs. r = 0.273, P = 0.032, respectively), PLR was found to be superior to NLR in terms of inflammation in ESRD patients. Simple calculation of PLR can predict inflammation better than NLR in ESRD patients.
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- Authors
- Turkmen, K., Erdur, F. M., Ozcicek, F., Ozcicek, A., Akbas, E. M., Ozbicer, A., Demirtas, L., Turk, S., & Tonbul, H. Z.
- Affiliations
- Department of Nephrology Erzincan University Mengucek Gazi Training and Reseach Hospital Erzincan Turkey
- Necmettin Erbakan University (TR)
- Department of Internal Medicine Erzincan University Mengucek Gazi Training and Reseach Hospital Erzincan Turkey
- Department of Endocrinology Erzincan University Mengucek Gazi Training and Reseach Hospital Erzincan Turkey
- Department of Nephrology Necmettin Erbakan University Meram School of Medicine Konya Turkey
- ORCID
- Tonbul, H. Zeki
- Venue
- Hemodialysis International
- Publisher
- Wiley
- Published
- 2013-03-24
- Volume
- 17
- Issue
- 3
- Pages
- 391-396
- ISSN
- 1492-7535 (ISSN-L)
- 1542-4758
- OpenAlex
- W1868383491
- Cited by
- 309
- References
- 28
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 23 · 2023: 24 · 2022: 34 · 2021: 37 · 2020: 31 · 2019: 29 · 2018: 21 · 2017: 27 · 2016: 28 · 2015: 13 · 2014: 15 · 2013: 5
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hemodialysis International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Keywords
- platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, end-stage renal disease, inflammation, C-reactive protein, interleukin-6, TNF-α, hemodialysis, peritoneal dialysis, inflammatory markers
- MeSH terms
- Blood Platelets, Cross-Sectional Studies, Female, Renal Dialysis, Humans, Inflammation, Kidney Failure, Chronic, Lymphocytes, Male, Middle Aged, Neutrophils
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