Platelet to lymphocyte ratio is associated with the severity of coronary artery disease and clinical outcomes of percutaneous coronary intervention in the Chinese Han population
Open accessAbstract
The aim of the present study was to evaluate whether the ratio of the absolute number of platelets to the number of lymphocytes (PLR) correlates with the severity of coronary artery disease (CAD) and major adverse cardiovascular disease (CVD) events in Chinese patients with CAD. PLR was calculated as follows: PLR=platelet count/lymphocyte count, using the complete blood counts of 854 Chinese Han subjects. CAD severity was determined using angiographic evidence by cardiologists unaware of the study aims. The association between PLR and CAD severity was analyzed by logistic regression. Clinical endpoints were evaluated during a median follow-up period of 42 months. The association between PLR and CVD events was assessed using Cox regression models. Patients with PLR>171 exhibited more severe coronary artery stenosis [odds ratio, 2.393; 95% confidence intervals (CI), 1.394-4.108; P=0.002] and worse prognoses, with a higher rate of major adverse CVD events during five years of follow-up (hazard ratio, 1.982; 95% CI, 1.329-2.957; P=0.001). A Kaplan-Meier curve demonstrated that the CVD event rate of 34.27% in patients with PLR>171 was significantly higher than that in patients with PLR<100 (P<0.001). These findings suggest that PLR is independently associated with CAD severity and long-term major adverse CVD events; therefore, high PLR may predict poor prognosis of CAD in the Chinese Han population.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PLR exhibited an independent association with both the severity of coronary heart disease and the occurrence of long-term Major Adverse Cardiovascular Events (MACEs) following PCI.
“Their findings indicated that PLR exhibited an independent association with both the severity of coronary heart disease and the occurrence of long-term Major Adverse Cardiovascular Events (MACEs) following PCI [34].”
From Residual Cardiovascular Risk: Role of Remnants Cholesterol, Monocyte/HDL Ratio and Lipoprotein Ratios on Personalized Cardiovascular Prevention (2024) · cites this paper as [34]
MHR was found to be independently correlated to the presence of metabolic syndrome.
“Furthermore, a peculiarity found is that this relationship was found to be independently correlated to the presence of metabolic syndrome [34].”
From Residual Cardiovascular Risk: Role of Remnants Cholesterol, Monocyte/HDL Ratio and Lipoprotein Ratios on Personalized Cardiovascular Prevention (2024) · cites this paper as [34]
Patients with PLR > 171 had more severe coronary stenosis and a worse prognosis, with a higher incidence of MACE during a 5-year follow-up.
“Patients with PLR > 171 had more severe coronary stenosis and a worse prognosis, with a higher incidence of MACE during a 5-year follow-up.”
From Residual Cardiovascular Risk: Role of Remnants Cholesterol, Monocyte/HDL Ratio and Lipoprotein Ratios on Personalized Cardiovascular Prevention (2024) · cites this paper as [34]
Cites
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,748 · see citing works
A more meaningful scoring system for determining the severity of coronary heart disease
Gensini, G. G. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80105-2 · Cited by 2,171 · see citing works
The inflammatory response in myocardial infarction
Frangogiannis, N. G. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00434-5 · Cited by 2,013 · see citing works
Tamhane, U. U., Aneja, S., Montgomery, D., Rogers, E., Eagle, K., & Gurm, H. (2008) · American Journal of Cardiology · doi:10.1016/j.amjcard.2008.05.006 · Cited by 918 · see citing works
Jono, S., Ikari, Y., Shioi, A., Mori, K., Miki, T., Hara, K., & Nishizawà, Y. (2002) · Circulation · doi:10.1161/01.cir.0000031524.49139.29 · Cited by 483 · see citing works
Thaulow, E., Erikssen, J., Sandvik, L., Stormorken, H., & Cohn, P. F. (1991) · Circulation · doi:10.1161/01.cir.84.2.613 · Cited by 458 · see citing works
Jennings, L. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-03-0192 · Cited by 436 · see citing works
Arbel, Y., Finkelstein, A., Halkin, A., Birati, E. Y., Revivo, M., Zuzut, M. E., Shevach, A., Berliner, S. A., Herz, I., Keren, G., et al. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.09.009 · Cited by 387 · see citing works
Platelets mediate cytotoxic T lymphocyte–induced liver damage
Iannacone, M., Sitia, G., Isogawa, M., Marchese, P., Castro, M., Lowenstein, P., Chisari, F., Ruggeri, Z., & Guidotti, L. (2005) · Nature Medicine · doi:10.1038/nm1317 · Cited by 347 · see citing works
B-Lymphocyte Deficiency Increases Atherosclerosis in LDL Receptor–Null Mice
Major, A. S., Fazio, S., & Linton, M. F. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000039169.47943.ee · Cited by 331 · see citing works
Turkmen, K., Erdur, F. M., Ozcicek, F., Ozcicek, A., Akbas, E. M., Ozbicer, A., Demirtas, L., Turk, S., & Tonbul, H. Z. (2013) · Hemodialysis International · doi:10.1111/hdi.12040 · Cited by 309 · see citing works
Usefulness of the Lymphocyte Concentration as a Prognostic Marker in Coronary Artery Disease
Ommen, S. R., Gibbons, R. J., Hodge, D. O., & Thomson, S. P. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)00878-8 · Cited by 302 · see citing works
Low Lymphocyte Count and Cardiovascular Diseases
Nunez, J., Minana, G., Bodı́, V., Nunez, E., Sanchís, J. M., Hüsser, O., & Llácer, Á. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711796391633 · Cited by 298 · see citing works
Gary, T., Pichler, M., Belaj, K., Hafner, F., Gerger, A., Froehlich, H., Eller, P., Rief, P., Hackl, G., Pilger, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067688 · Cited by 296 · see citing works
Akpek, M., Kaya, M. G., Lam, Y. Y., Şahin, Ö., Elçik, D., Celık, T., Ergin, A., & Gibson, C. M. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.041 · Cited by 233 · see citing works
Sunbul, M., Gerin, F., Durmuş, E., Kıvrak, T., Sari, I., Tigen, K., & Cincin, A. (2014) · Clinical and experimental hypertension · doi:10.3109/10641963.2013.804547 · Cited by 224 · see citing works
Platelet-vessel wall interactions in atherosclerotic disease
Langer, H., & Gawaz, M. (2008) · Thrombosis and Haemostasis · doi:10.1160/th07-11-0685 · Cited by 204 · see citing works
Akboğa, M. K., Canpolat, U., Yayla, Ç., Özcan, F., Özeke, Ö., Topaloğlu, S., & Aras, D. (2015) · Angiology · doi:10.1177/0003319715583186 · Cited by 149 · see citing works
Vaduganathan, M., Ambrosy, A. P., Greene, S. J., Mentz, R. J., Subacius, H. P., Maggioni, A. P., Swedberg, K. B., Nodari, S., Zannad, F. M., Konstam, M. A., et al. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.970525 · Cited by 133 · see citing works
Platelet aggregation is dependent on platelet count in patients with coronary artery disease
Würtz, M., Hvas, A., Kristensen, S. D., & Grove, E. L. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.08.019 · Cited by 114 · see citing works
Akboğa, M. K., Canpolat, U., Yüksel, M., Yayla, Ç., Yılmaz, S., Turak, O., Özeke, Ö., Topaloğlu, S., & Aras, D. (2015) · Platelets · doi:10.3109/09537104.2015.1064518 · Cited by 114 · see citing works
Çetin, E. H. Ö., Çetin, M. S., Aras, D., Topaloğlu, S., Temizhan, A., Kisacik, H. L., & Aydoğdu, S. (2015) · Angiology · doi:10.1177/0003319715591751 · Cited by 106 · see citing works
Çiçek, G., Açi̇kgöz, S. K., Bozbay, M., Altay, S., Uğur, M., Uluganyan, M., & Uyarel, H. (2014) · Angiology · doi:10.1177/0003319714535970 · Cited by 95 · see citing works
Estimation of LDL cholesterol based on the Friedewald formula and on apo B levels
Bairaktari, E. T., Hatzidimou, K., Tzallas, C. S., Vini, M. P., Katsaraki, A., Tselepis, A. D., Elisaf, M., & Tsolas, O. (2000) · Clinical Biochemistry · doi:10.1016/s0009-9120(00)00162-4 · Cited by 93 · see citing works
Thymidine Phosphorylase Participates in Platelet Signaling and Promotes Thrombosis
Li, W., Gigante, A. E. I., Pérez‐Pérez, M., Yue, H., Hirano, M., McIntyre, T. M., & Silverstein, R. L. (2014) · Circulation Research · doi:10.1161/circresaha.115.304591 · Cited by 59 · see citing works
Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties
Wirtz, T. H., Tillmann, S., Strüßmann, T., Kraemer, S., Heemskerk, J. W. M., Grottke, O., Gawaz, M., von Hundelshausen, P., & Bernhagen, J. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.039 · Cited by 57 · see citing works
Alarcón, M. A., Eduardo Fuentes, Q., Olate, N., Navarrete, S., Carrasco, G. A., & Palomo, I. F. (2014) · Platelets · doi:10.3109/09537104.2014.898747 · Cited by 52 · see citing works
Platelet to lymphocyte ratio: A simple and valuable prognostic marker for acute coronary syndrome
Akkaya, E., Gül, M., & Uğur, M. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.143 · Cited by 52 · see citing works
Platelet, Not Endothelial, P-Selectin Is Required for Neointimal Formation After Vascular Injury
Wang, K., Zhou, X., Zhou, Z., Mal, N., Fan, L., Zhang, M., Lincoff, A. M., Plow, E. F., Topol, E. J., & Penn, M. S. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000172687.01179.d4 · Cited by 41 · see citing works
Complications of selective coronary arteriography by the Judkins technique and their prevention
Shah, A., Gnoj, J., & Fisher, V. J. (1975) · American Heart Journal · doi:10.1016/0002-8703(75)90325-7 · Cited by 29 · see citing works
Weng, T., Fu, T., Chao-Hung, W., Hsu, C., & Wang, J. (2014) · Clinical Science · doi:10.1042/cs20130789 · Cited by 21 · see citing works
Hong, L.-F., Li, X., Luo, S.-H., Guo, Y., Liu, J., Zhu, C., Qing, P., Xu, R., Wu, N., Jiang, L., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090663 · Cited by 19 · see citing works
Suzuki, T., Futami‐Suda, S., Igari, Y., Watanabe, K., Ouchi, M., Suzuki, K., Sekimizu, K.-I., Kigawa, Y., Nakano, H., & Oba, K. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-31 · Cited by 17 · see citing works
Cong, Y., Jin, D., Wang, H., Okada, T., & Peng, Z.-H. (2003) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Platelet to Lymphocyte Ratio in Cardiovascular Diseases: A Systematic Review
Kurtul, A., & Örnek, E. (2019) · Angiology · doi:10.1177/0003319719845186 · Cited by 194 · see citing works
Kalyoncuoğlu, M., & Durmuş, G. (2019) · Coronary Artery Disease · doi:10.1097/mca.0000000000000768 · Cited by 78 · see citing works
Urbanowicz, T. K., Olasińska‐Wiśniewska, A., Michalak, M., Rodzki, M., Witkowska, A., Straburzyńska‐Migaj, E., Perek, B., & Jemielity, M. (2021) · Biology · doi:10.3390/biology11010034 · Cited by 65 · see citing works
Chen, T., & Yang, M. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106063 · Cited by 54 · see citing works
Russu, E., Mureṣan, A., Arbănași, E.-M., Kaller, R., Hosu, I., Voidăzan, S., Arbănași, E.-M., & Coșarcă, C. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092620 · Cited by 52 · see citing works
Qiu, Z., Jiang, Y., Jiang, X., Yang, R., Wu, Y., Xu, Y., & Cheng, X. (2020) · Angiology · doi:10.1177/0003319720943810 · Cited by 48 · see citing works
Arbănași, E. M., Mureșan, A. V., Coșarcă, C. M., Kaller, R., Bud, T. I., Hosu, I., Voidăzan, S. T., Arbănași, E. M., & Arbănași, E. M. (2022) · Life · doi:10.3390/life12060822 · Cited by 46 · see citing works
Mangalesh, S., Dudani, S., & Mahesh, N. K. (2023) · Angiology · doi:10.1177/00033197231151564 · Cited by 41 · see citing works
Manoochehri, H., Gheitasi, R., Pourjafar, M., Amini, R., & Ahmadieh-Yazdi, A. (2021) · Medical Journal of the Islamic Republic of Iran · doi:10.47176/mjiri.35.85 · Cited by 38 · see citing works
Wang, H., Li, L., & Ma, Y. (2023) · Clinical Cardiology · doi:10.1002/clc.24002 · Cited by 39 · see citing works
Platelet to lymphocyte ratio in acute aortic dissection
Sbarouni, E., Γεωργιάδου, Π., Kosmas, I., Analitis, A., & Voudris, V. A. (2018) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22447 · Cited by 32 · see citing works
Gao, X., Liu, Y., Tian, Y., Rao, C., Shi, F., Bu, H., Liu, J., Zhang, Y., Shan, W., Ding, Z., et al. (2021) · Journal of International Medical Research · doi:10.1177/03000605211010059 · Cited by 21 · see citing works
Prognostic Value of Multiple Complete Blood Count-Derived Indices in Intermediate Coronary Lesions
Yang, Y., Song, C., Jia, L., Dong, Q., Song, W., Yin, D., & Dou, K. (2023) · Angiology · doi:10.1177/00033197231198678 · Cited by 20 · see citing works
Króliczewska, B., Miśta, D., Ziarnik, A., Żuk, M., Szopa, J., Pecka‐Kiełb, E., Zawadzki, W., & Króliczewski, J. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0726-4 · Cited by 21 · see citing works
Lareyre, F., Carboni, J., Chikande, J., Massiot, N., Voury-Pons, A., Umbdenstock, E., Jean‐Baptiste, E., Hassen‐Khodja, R., & Raffort, J. (2018) · Vascular and Endovascular Surgery · doi:10.1177/1538574418789046 · Cited by 19 · see citing works
Tangjitgamol, S., Udayachalerm, W., Wanishsawad, C., Kaewwanna, W., & Ativanichayapong, N. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s447750 · Cited by 19 · see citing works
Sucato, V., Coppola, G., Testa, G., Amata, F., Martello, M., Siddique, R., Galassi, A. R., Novo, G., & Corrado, E. (2021) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.04.007 · Cited by 15 · see citing works
Xu, R., Chen, L., Yan, C.-S., Xu, H., & Cao, G.-Q. (2025) · The Journal of Clinical Hypertension · doi:10.1111/jch.14980 · Cited by 13 · see citing works
Wang, Y., & Peng, Z. (2021) · Medicine · doi:10.1097/md.0000000000026942 · Cited by 13 · see citing works
Sucato, V., Comparato, F., Ortello, A., Galassi, A. R., & Novo, G. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14050460 · Cited by 12 · see citing works
“Their findings indicated that PLR exhibited an independent association with both the severity of coronary heart disease and the occurrence of long-term Major Adverse Cardiovascular Events (MACEs) following PCI [34].”
BackgroundHafezi, S. G., Ahari, R. K., Saberi‐Karimian, M., Giski, Z. E., Mansoori, A., Ferns, G. A., Ebrahimi, M., Heidari‐Bakavoli, A., Moohebati, M., Yousefian, S., et al. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05122-w · Cited by 8 · see citing works
Clinical Value of Platelet Indices in Premature Coronary Artery Disease
Chen, K., Zhang, R., Chen, S., Fan, X., Shen, L., & Yuan, H. (2023) · International Heart Journal · doi:10.1536/ihj.22-442 · Cited by 6 · see citing works
Zhen, Y., Chang, Z., Liu, Z., & Zheng, J. (2020) · BMC Cardiovascular Disorders · doi:10.1186/s12872-019-01314-1 · Cited by 6 · see citing works
Karakurt, A., & Yıldız, C. (2018) · International Journal of the Cardiovascular Academy · doi:10.4103/ijca.ijca_29_18 · Cited by 5 · see citing works
Pek, E., Beyazıt, F., & Korkmaz, N. (2020) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.37.1.2774 · Cited by 4 · see citing works
Hematological Biomarkers, Mortality, Transfusion and Acute Heart Disease
Rahimi‐Levene, N., Preisler, Y., Koren‐Michowitz, M., Peer, V., Zeidenstein, R., Golik, A., & Ziv‐Baran, T. (2021) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2021.04.017 · Cited by 4 · see citing works
Kofos, C., Papazoglou, A., Fyntanidou, B., Samaras, A., Stachteas, P., Nasoufidou, A., Apostolopoulou, A., Karakasis, P., Arvanitaki, A., Bantidos, M. G., et al. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12090334 · Cited by 9 · see citing works
The relationship between platelet to lymphocyte ratio and the diurnal variation of hypertension
ÇELEBİ, S. (2020) · Turkish Journal of Clinics and Laboratory · doi:10.18663/tjcl.648347 · Cited by 2 · see citing works
邵, 彩. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.113181 · Cited by 2 · see citing works
Zhao, J., Li, Z., Fu, S., Fu, M., Fu, S., & Fu, S. (2025) · European journal of medical research · doi:10.1186/s40001-025-03494-3 · Cited by 1 · see citing works
Sastrawan, I. P. Y., & Shalim, C. P. (2019) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2020.v13i1.35609 · Cited by 1 · see citing works
Abdullah, K., Afrizal, A., Diah, M., & Gani, A. (2022) · International Journal of Research Publications · doi:10.47119/ijrp1001021620223246 · Cited by 1 · see citing works
Predictive Value of HALP Score in The Early Stage of NSTEMI
Yıldız, G., Ayyıldız, F. A., & Yıldırım, Ö. T. (2024) · Cukurova Anestezi ve Cerrahi Bilimler Dergisi · doi:10.36516/jocass.1396148 · Cited by 1 · see citing works
The Importance of Hemogram Parameters in Family Medicine for Coronary Artery Disease
Özsarı, S., & Ozsari, E. (2017) · Eurasian Journal of Medicine and Oncology · doi:10.14744/ejmo.2017.26818
ALI, M. D. H. R. S. T. (2019) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2019.59319
Muliana, M., Rahmat, B., & Priyambodo, S. (2020) · Mutiara Medika: Jurnal Kedokteran dan Kesehatan · doi:10.18196/mm.200136
Çakır, H., Toprak, C., Karagöz, A., Uysal, S., Havan, N., Kuzeytemiz, M., Kaymaz, C., & Demir, M. (2022) · The European Research Journal · doi:10.18621/eurj.1125452
Tosun, V. (2023) · International Journal Of Medical Science And Clinical Invention · doi:10.18535/ijmsci/v10i10.01
Hafezi, S. G., Behkamal, B., Rashidmayvan, M., Hosseini, M., Yadegari, M., Ghoflchi, S., Mansoori, A., Ghamsary, M. G., Ferns, G., Saberi, M. R., et al. (2024) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2024.105446
Króliczewska, B., Miśta, D., Ziarnik, A., Żuk, M., Szopa, J., Pecka‐Kiełb, E., Wojciech, Z., & Króliczewski, J. (2020) · Figshare · doi:10.6084/m9.figshare.11981334
- Authors
- Zhou, D., Wang, G., Fan, Y., Wan, Z., & Liu, X.
- Affiliations
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Guangxi Zhuang Autonomous Region Brain Hospital (CN)
- Venue
- Experimental and Therapeutic Medicine
- Publisher
- Spandidos Publications
- Published
- 2016-12-22
- Volume
- 13
- Issue
- 2
- Pages
- 731-738
- ISSN
- 1792-0981 (ISSN-L)
- 1792-1015
- PMC
- PMC5348707
- OpenAlex
- W2564729975
- Cited by
- 40
- References
- 34
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Experimental and Therapeutic Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2012CB517804, 81025002)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Keywords
- platelet-to-lymphocyte ratio, coronary artery disease, disease severity, major adverse cardiovascular events, prognostic factors, percutaneous coronary intervention, coronary artery stenosis, Han Chinese
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
