Effect of IL-6, IL-8/CXCL8, IP-10/CXCL 10 levels on the severity in COVID 19 infection
Open accessAbstract
BACKGROUND: COVID 19 was first observed in December 2019 and has affected the world entire. Effective laboratory markers and prognostic indicators are needed to predict the clinical progression of the disease. AIMS: The purpose of this study was to investigate IL6, IL8/CXCL8, and IP10/CXCL10, and biochemical parameters associated with SARS, MERS, and SARS-CoV-2 infections and their significance on prognosis in healthy volunteers and mild-moderate and severe COVID 19 patients. METHODS: Healthy volunteers (n = 30), and patients with mild-moderate (n = 30) and severe (n = 30) COVID-19 patients were included in the study. IL-6, IL-8, and IP-10 levels and biochemical parameters were assessed among the groups and their correlations with each other were subjected to statistical analysis. RESULTS: Blood serum IL-6, IL-8, and IP-10 levels were the highest in the severe patient group (P = .001), and also higher in the mild-moderate group as compared with the healthy volunteers (P = .001). Statistically significant positive correlations were identified between serum IL-8 and IL-6 levels (P = .001, r = 0.660), between serum IP-10 and IL-6 (P = .001, r = 0.599) and between serum IP-10 and IL-8 (P = .001, r = 0.729). CONCLUSIONS: A statistically significant difference was found in WBC, NE%, NE, LY%, LY, HB, BUN, total protein, albumin, d-dimer, sedimentation differed significantly between the groups. Biomarkers of potential significance in terms of the severity of COVID 19 disease were examined, and high IL-6, IL-8, IP-10, CRP, PCT, and LY parameters values emerged as associated with the severity of the disease.
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Elevated levels of IL-6 and IL-8 may indicate infection as the causative agent of AIN.
“In a similar context, elevated levels of IL-6 and IL-8 may indicate infection as the causative agent of AIN [59, 98–101].”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [99]
The Results (page unavailable) report higher serum IL-6 and IL-8 in patients with COVID-19 than in healthy volunteers. The paper does not examine AIN or establish that elevated levels indicate infection as its causative agent. (LLM, conf=0.87)
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CYTOKINES AS POTENTIAL MARKERS OF COVID-19 SEVERITY AND OUTCOMES
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- Authors
- Kesmez Can, F., Özkurt, Z., Öztürk, N., & Sezen, S.
- Affiliations
- Department of Infectious Diseases and Clinical Microbiology Atatürk University School of Medicine Erzurum Turkey
- Atatürk University (TR)
- Venue
- International Journal of Clinical Practice
- Publisher
- Wiley
- Published
- 2021-10-22
- Volume
- 75
- Issue
- 12
- Pages
- e14970-e14970
- ISSN
- 1368-5031 (ISSN-L)
- 1742-1241
- PMC
- PMC8646602
- OpenAlex
- W3205294997
- Cited by
- 66
- References
- 30
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 19 · 2023: 19 · 2022: 14 · 2021: 1
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- International Journal of Clinical Practice (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Atatürk Üniversitesi (THD‐2020‐8619)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- COVID-19 pandemic, SARS-CoV-2, interleukin-6, interleukin-8, CXCL10, disease severity, prognostic factors, C-reactive protein, procalcitonin, lymphocyte percentage, D-dimer, serum cytokines
- MeSH terms
- COVID-19, SARS-CoV-2, Humans, Prognosis, Severity of Illness Index, Biomarkers, Interleukin-6, Interleukin-8, Chemokine CXCL10
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