Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients
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Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response.
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NF-κB-dependent proinflammatory mediators can drive accumulation of pathogenic neutrophils and macrophages in the lung, perpetuating cytokine and chemokine elevation in BALF and circulation.
“Accumulation of NF-κB-dependent proinflammatory mediators can provoke an accumulation of pathogenic inflammatory neutrophils and macrophages in the lung”
From COVID-19 and the human innate immune system (2021) · cites this paper as Xiong et al., 2020
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RetractedHydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis
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The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections
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The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules
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COVID-19 Hyperinflammation: What about Neutrophils?
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The trans-omics landscape of COVID-19
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Self-citationThe potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19
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The SARS-CoV-2 subgenome landscape and its novel regulatory features
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Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity
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Immune and Metabolic Signatures of COVID-19 Revealed by Transcriptomics Data Reuse
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NK cells: A double edge sword against SARS-CoV-2
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- Authors
- Xiong, Y., Liu, Y., Cao, L., Wang, D., Guo, M., Jiang, A., Guo, D., Hu, W., Yang, J., Tang, Z., Wu, H., Lin, Y., Zhang, M., Zhang, Q., Shi, M., Liu, Y., Zhou, Y., Lan, K., & Chen, Y.
- Affiliations
- Wuhan University (CN)
- Sun Yat-sen University (CN)
- BGI Group (China) (CN)
- State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University
- The Centre for Infection and Immunity Studies, School of Medicine, Sun Yat-sen University
- Corresponding author
- Zhou, Yu
- Lan, Ke
- Chen, Yu
- ORCID
- Venue
- Emerging Microbes & Infections
- Publisher
- Informa UK Limited
- Published
- 2020-01
- Volume
- 9
- Issue
- 1
- Pages
- 761-770
- ISSN
- 2222-1751 (ISSN-L)
- PMC
- PMC7170362
- OpenAlex
- W3013843138
- Cited by
- 1,076
- References
- 53
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 68 · 2023: 121 · 2022: 206 · 2021: 370 · 2020: 272
- FWCI
- 31.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Emerging Microbes & Infections (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Funders
- National Natural Science Foundation of China (31871316, COVID-19)
- Wuhan University
- National Science and Technology Major Project (#2018ZX10733403)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- COVID-19 pandemic, SARS-CoV-2, bronchoalveolar lavage fluid, peripheral blood mononuclear cells, host immune response, inflammatory cytokines, chemokines, lymphopenia, apoptosis, p53 pathway, lymphocyte activation, transcriptome
- MeSH terms
- Betacoronavirus, RNA-Seq, COVID-19, SARS-CoV-2, Bronchoalveolar Lavage Fluid, Humans, Leukocytes, Mononuclear, Lymphopenia, Pneumonia, Viral, Signal Transduction, Tumor Suppressor Protein p53, Cytokines, Apoptosis, Coronavirus Infections, Chemokines, Pandemics, Transcriptome
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