CoChat
Sign Up
Cited by 83Acne and Rosacea Treatments and EffectsDermatology and Skin DiseasesDermatologic Treatments and Research

Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris

Khodaeiani, Effat, Fouladi, Rohollah Fadaei, Amirnia, Mehdi, Saeidi, Majid, Karimi, Elham Razagh·2013·International Journal of Dermatology
DOI 10.1111/ijd.12002
Open this paper in CoChat — free account

Abstract

Nicotinamide and clindamycin gels are two popular topical medications for acne vulgaris. This study aimed to compare efficacy of the topical 4% nicotinamide and 1% clindamycin gels in these patients. In this randomized, double‐blind clinical trial, patients with moderate inflammatory facial acne vulgaris were randomly allocated to receive either topical 4% nicotinamide (n = 40) or 1% clindamycin gels (n = 40) twice daily. In each group, they were further categorized in two subgroups with oily and non‐oily types of facial skin. The Cook's acne grade was determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased from an average of 5.93 ± 0.83 at baseline to 4.03 ± 1.33 at week 4 and 2.08 ± 1.59 at week 8 in nicotinamide receivers, and from an average of 5.70 ± 0.94 at baseline to 3.85 ± 1.66 at week 4 and 2.03 ± 1.53 at week 8 in the clindamycin group (within‐group P < 0.001, between‐group P > 0.05). Comparing with each other, nicotinamide and clindamycin gels were significantly more efficacious in oily and non‐oily skin types, respectively. No major side effect was encountered by any patient. Skin type is a significant factor in choosing between topical nicotinamide and clindamycin in patients with acne vulgaris.

Integrity signals

Registry

Crossref · 10.1111/ijd.12002

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Among the randomized controlled trials on global acne severity, three showed that dermocosmetics were significantly superior to comparators or placebo in improving acne.

    “three showed that dermocosmetics were significantly superior in improving acne versus comparators or placebo”

    From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [19]

  • Among the randomized controlled trials on global acne severity, two showed that dermocosmetic products had an effect on acne severity comparable to benzoyl peroxide 2.5% or 5% and retinoic acid 0.025%.

    “two showed that dermocosmetic products had an effect on acne severity comparable to BPO 2.5% or 5% and retinoic acid 0.025%.”

    From International expert consensus recommendations for the use of dermocosmetics in acne. (2025) · cites this paper as [19]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Khodaeiani, E., Fouladi, R. F., Amirnia, M., Saeidi, M., & Karimi, E. R.
Affiliations
  • Department of Dermatology Sina Hospital Tabriz Iran
  • Tabriz University of Medical Sciences (IR)
  • Faculty of Pharmacy Sari University of Medical Sciences Sari Iran
Corresponding author
Fouladi, Rohollah Fadaei
ORCID
Amirnia, Mehdi
Venue
International Journal of Dermatology
Publisher
Wiley
Published
2013-06-20
Volume
52
Issue
8
Pages
999-1004
ISSN
  • 0011-9059 (ISSN-L)
  • 1365-4632
DOI
10.1111/ijd.12002
OpenAlex
W2158204858
Cited by
83
References
33
Citations by year
2026: 5 · 2025: 9 · 2024: 7 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 1 · 2014: 13 · 2013: 3
FWCI
8.57
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • International Journal of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
acne, nicotinamide, clindamycin, topical gel, inflammatory acne, oily skin, skin type, treatment efficacy, facial acne
MeSH terms
Acne Vulgaris, Administration, Topical, Adolescent, Adult, Anti-Bacterial Agents, Clindamycin, Double-Blind Method, Female, Humans, Male, Niacinamide, Severity of Illness Index, Vitamin B Complex, Treatment Outcome, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review