CoChat
Sign Up
Cited by 2Phytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stressPomegranate: compositions and health benefits

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Effects of isomerisation and oxidation on the immunomodulatory activity of chlorogenic acid in RAW264.7 macrophages

Guo, Chongting, Bi, Jinfeng, Li, Xuan, Lyu, Jian, Liu, Xuan, Liu, Jianing, Xu, Ye, Hu, Jiaxing·2022·International Journal of Food Science & Technology
DOI 10.1111/ijfs.15442
Open this paper in CoChat — free account

Abstract

Summary: Chlorogenic acid (CA) is one of the major polyphenols in fruit that contributes to most bioactivities. However, it is susceptible to isomerisation and oxidation in processing and thus displays varied bioactivity. This study aimed to evaluate the isomerisation and oxidation effects of CA on the potential immunomodulatory activity in RAW264.7 macrophages through the NF‐E2‐related factor‐2 (Nrf2) and nuclear factor‐kappa B (NF‐ κ B) signalling pathways. The results showed that isomerisation significantly affected the immunomodulation of CA by reducing Nrf2 and increasing NF‐ κ B nuclear translocation. The oxidation of CA weakened the effect of immune regulation in macrophages through impacts on the nucleic translocation of Nrf2 and NF‐ κ B, cellular reactive oxygen species (ROS) accumulation, antioxidant enzyme (superoxide dismutase, SOD) activity and cytokine expression. Consequently, isomerisation and oxidation remarkably affect the immunomodulation of CA via the Nrf2 and NF‐ κ B pathways.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/ijfs.15442

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 55

  1. 10.1111/ijfs.14060 · DOI
  2. 10.1002/mnfr.201800840 · DOI
  3. 10.1016/j.jcs.2018.04.011 · DOI
  4. 10.1093/jn/138.5.833 · DOI
  5. 10.1177/011542650802300149 · DOI
  6. Dai Y., 2015, Immunoregulation effect of chlorogenic acid on mouse peritoneal macrophages, Natural Product Research Development, 27, 2128
  7. 10.1002/mnfr.201400568 · DOI
  8. Ding Y.P., 2017, Progress in catechins oxidation products and their formation mechanism, China J. Chin. Mater. Med, 42, 239
  9. 10.1016/j.pestbp.2019.03.017 · DOI
  10. 10.1080/15384101.2019.1612697 · DOI
  11. 10.1016/j.tifs.2020.01.010 · DOI
  12. 10.1016/j.foodchem.2020.127931 · DOI
  13. 10.1016/j.freeradbiomed.2019.04.014 · DOI
  14. 10.1021/acs.jafc.7b05894 · DOI
  15. 10.1517/14728222.5.6.697 · DOI
  16. 10.1016/j.jnutbio.2013.05.007 · DOI
  17. 10.1016/j.fbio.2020.100636 · DOI
  18. 10.1007/s11064-015-1659-1 · DOI
  19. 10.1038/s41590-018-0113-3 · DOI
  20. Lee J.H., 2017, Determination of miroestrol and isomiroestrol from Pueraria mirifica (white kwao krua) in dietary supplements by LC‐MS‐MS and LC‐Q‐Orbitrap/MS, Journal of Chromatographic Science, 55, 214
  21. 10.1039/C2FO30093A · DOI
  22. 10.1007/s11010-019-03516-9 · DOI
  23. 10.1021/acs.jafc.8b03983 · DOI
  24. 10.1016/j.lwt.2015.04.052 · DOI
  25. 10.1016/j.lfs.2014.12.028 · DOI
  26. 10.1111/1541-4337.12797 · DOI
  27. 10.1007/s00394-012-0435-0 · DOI
  28. 10.1007/s11947-009-0241-8 · DOI
  29. 10.1002/mnfr.201501017 · DOI
  30. 10.1023/B:PHYT.0000047811.13837.fb · DOI
  31. 10.1021/jf00023a015 · DOI
  32. 10.1016/j.foodres.2019.05.029 · DOI
  33. 10.1016/j.indcrop.2018.09.027 · DOI
  34. 10.4028/www.scientific.net/AMR.550-553.1270 · DOI
  35. 10.1016/j.biopha.2018.12.074 · DOI · Paper page
  36. 10.1016/j.intimp.2017.11.007 · DOI
  37. 10.1016/j.clnu.2016.03.002 · DOI
  38. 10.1016/j.foodchem.2014.06.100 · DOI
  39. 10.1021/jf202561p · DOI
  40. 10.1002/mnfr.201200540 · DOI
  41. Spelman K., 2006, Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators, Altern. Med. Rev, 11, 128
  42. 10.1007/s00011-013-0674-4 · DOI
  43. 10.1021/jf0207530 · DOI
  44. 10.1172/JCI11830 · DOI · Paper page
  45. 10.1038/nrd2803 · DOI · Paper page
  46. 10.1016/S0024-3205(97)01150-8 · DOI
  47. 10.1016/j.fct.2018.08.061 · DOI
  48. 10.1073/pnas.94.10.5361 · DOI
  49. 10.1021/jf303771s · DOI
  50. 10.1016/j.cgh.2014.07.029 · DOI
  51. 10.1039/C8FO01281D · DOI
  52. 10.1016/j.jep.2020.113402 · DOI
  53. 10.1039/C7FO01754E · DOI
  54. 10.1016/j.intimp.2020.106436 · DOI
  55. 10.1021/jf991188c · DOI

Metadata

Authors
Guo, C., Bi, J., Li, X., Lyu, J., Liu, X., Liu, J., Xu, Y., & Hu, J.
Affiliations
  • Shenyang Agricultural University (CN)
  • Institute of Food Science and Technology (CN)
Corresponding author
  • Bi, Jinfeng
  • Li, Xuan
ORCID
Venue
International Journal of Food Science & Technology
Publisher
Oxford University Press (OUP)
Published
2021-11-21
Volume
57
Issue
2
Pages
951-962
ISSN
  • 0950-5423 (ISSN-L)
  • 1365-2621
DOI
10.1111/ijfs.15442
OpenAlex
W3214083231
Cited by
2
References
1
Citations by year
2026: 1 · 2022: 1
FWCI
0.14
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
International Journal of Food Science & Technology (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords
chlorogenic acid, isomerization, oxidation, immunomodulation, RAW 264.7 macrophages, Nrf2 signaling, NF-κB signaling, reactive oxygen species, superoxide dismutase, cytokine expression, polyphenols, food processing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review