Antioxidative and prooxidative effects of quercetin on A549 cells
Abstract
Quercetin, a common plant polyphenol, has been reported to show both antioxidant and prooxidant properties. We studied the effects of quercetin on A549 cells in in vitro culture. We found that low concentrations of the flavonoid stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; while higher concentrations of the flavonoid decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase. Quercetin decreased production of reactive oxygen species in the cells but produced peroxides in the medium. The cellular effects of quercetin are therefore complex and include both antioxidant effects and induction of oxidative stress due to formation of reactive oxygen species in the extracellular medium.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
High doses of some antioxidants, such as quercetin and flavonoids, reduce cell survival.
“Studies have also suggested that high doses of some antioxidants, such as quercetin and flavonoids, reduce cell survival35,37,38.”
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Antioxidant activity applying an improved ABTS radical cation decolorization assay
Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,298 · see citing works
Habig, W. H., Pabst, M. J., & Jakoby, W. B. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42083-8 · Cited by 18,396 · see citing works
Misra, H. P., & Fridovich, I. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45228-9 · Cited by 9,097 · see citing works
A SPECTROPHOTOMETRIC METHOD FOR MEASURING THE BREAKDOWN OF HYDROGEN PEROXIDE BY CATALASE
Beers, R. F., & Sizer, I. W. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50881-x · Cited by 6,781 · see citing works
Antioxidant and Prooxidant Behavior of Flavonoids: Structure-Activity Relationships
Cao, G., Sofic, E., & Prior, R. L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00351-6 · Cited by 2,415 · see citing works
Royall, J. A., & Ischiropoulos, H. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1222 · Cited by 1,123 · see citing works
Twentyman, P., & Luscombe, M. (1987) · British Journal of Cancer · doi:10.1038/bjc.1987.190 · Cited by 988 · see citing works
Oxidative stress and redox regulation of lung inflammation in COPD
Rahman, I., & Adcock, I. M. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00053805 · Cited by 943 · see citing works
Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective
Ratnam, D. V., Ankola, D. D., Bhardwaj, V., Sahana, D. K., & Kumar, M. N. V. R. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.015 · Cited by 885 · see citing works
Myhre, O., Andersen, J. M., Aarnes, H., & Fonnum, F. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00083-2 · Cited by 624 · see citing works
Galati, G. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00198-1 · Cited by 530 · see citing works
Metodiewa, D., Jaiswal, A. K., Čėnas, N., Dičkancaitė, E., & Segura‐Aguilar, J. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00167-1 · Cited by 515 · see citing works
Techniques in Free Radical Research
(1991) · Laboratory techniques in biochemistry and molecular biology · doi:10.1016/s0075-7535(08)x7003-2 · Cited by 441 · see citing works
Cho, S., Park, S., Kwon, M.-J., Jeong, T., Bok, S., Choi, W., Jeong, W., Ryu, S., Hee, S., Lee, C., et al. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1021624520740 · Cited by 352 · see citing works
Alía, M., Mateos, R., Ramos, S., Lecumberri, E., Bravo, L., & Goya, L. (2005) · European Journal of Nutrition · doi:10.1007/s00394-005-0558-7 · Cited by 259 · see citing works
A comparison of the anticarcinogenic properties of four red wine polyphenols
Soleas, G. J., Grass, L., Josephy, P. D., Goldberg, D. M., & Diamandis, E. P. (2002) · Clinical Biochemistry · doi:10.1016/s0009-9120(02)00275-8 · Cited by 251 · see citing works
Reactive Oxygen Species and Regulation of Gene Expression
Turpaev, K. T. (2002) · Biochemistry (Moscow) · doi:10.1023/a:1014819832003 · Cited by 249 · see citing works
Bratosin, D., Mitrofan, L. M., Palii, C. G., Estaquier, J., & Montreuil, J. (2005) · Cytometry Part A · doi:10.1002/cyto.a.20152 · Cited by 237 · see citing works
Phenolic compounds protect HepG2 cells from oxidative damage: Relevance of glutathione levels
Lima, C. F., Fernandes‐Ferreira, M., & Pereira‐Wilson, C. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.042 · Cited by 231 · see citing works
Sieuwerts, A. M., Klijn, J. G. M., Peters, H. A., & Foekens, J. A. (1995) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1995.33.11.813 · Cited by 208 · see citing works
Mamani‐Matsuda, M., Kauss, T., Al-Kharrat, A., Rambert, J., Fawaz, F., Thiolat, D., Moynet, D. J., Coves, S., Malvy, D. J.-M., & Mossalayi, M. D. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.001 · Cited by 201 · see citing works
Antioxidant and Prooxidant Effects of Phenolics on Pancreatic β-Cells in Vitro
Lapidot, T., WALKER, M. D., & Kanner, J. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020615a · Cited by 196 · see citing works
The production of reactive oxygen species by dietary flavonols
Canada, A. T., Giannella, E., Nguyen, T. D., & Mason, R. P. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90022-b · Cited by 146 · see citing works
Antihypertensive Effect of Quercetin in Rats Fed with a High-Fat High-Sucrose Diet
Yamamoto, Y., & Eriko, O. U. E. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.933 · Cited by 139 · see citing works
Redox signalling in anchorage-dependent cell growth
Chiarugi, P., & Fiaschi, T. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.11.009 · Cited by 134 · see citing works
Sahu, S. C., & Gray, G. C. (1996) · Cancer Letters · doi:10.1016/0304-3835(96)04251-6 · Cited by 116 · see citing works
Distinct mechanisms of DNA damage in apoptosis induced by quercetin and luteolin
Yamashita, N., & Kawanishi, S. (2000) · Free Radical Research · doi:10.1080/10715760000301141 · Cited by 112 · see citing works
Antiproliferative Effects of Dietary Phenolic Substances and Hydrogen Peroxide
Lee, K. W., Hur, H. J., Lee, H. J., & Lee, C. Y. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0486040 · Cited by 108 · see citing works
Quercetin Induces Necrosis and Apoptosis in SCC-9 Oral Cancer Cells
Haghiac, M., & Walle, T. (2005) · Nutrition and Cancer · doi:10.1207/s15327914nc5302_11 · Cited by 106 · see citing works
Antimutagenic and Antioxidant Properties of Phenolic Fractions from Andean Purple Corn (Zea mays L.)
Pedreschi, R., & Cisneros‐Zevallos, L. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0531050 · Cited by 105 · see citing works
Ferraresi, R., Troiano, L., Roat, E., Lugli, E., Nemes, E., Nasi, M., Pinti, M., Garcia‐Fernandez, M. I., Cooper, E. L., & Cossarizza, A. (2005) · Free Radical Research · doi:10.1080/10715760500306935 · Cited by 98 · see citing works
Thiols are Main Determinants of Total Antioxidant Capacity of Cellular Homogenates
Balcerczyk, A., & Bartosz, G. (2003) · Free Radical Research · doi:10.1080/1071576031000083189 · Cited by 84 · see citing works
Self-citationKhramtsov, V. V., Yelinova, V. I., Glazachev, Y. I., Резников, В. А., & Zimmer, G. (1997) · Journal of Biochemical and Biophysical Methods · doi:10.1016/s0165-022x(97)00035-3 · Cited by 65 · see citing works
A comparison of the anticarcinogenic properties of four red wine polyphenols
(2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.04.014 · Cited by 54 · see citing works
Flow cytometry in the study of cell death
Bertho, Á. L., Santiago, M. A., & Coutinho, S. G. (2000) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762000000300020 · Cited by 53 · see citing works
Yeomans, V. C., Linseisen, J., & Wolfram, G. (2005) · European Journal of Nutrition · doi:10.1007/s00394-005-0546-y · Cited by 45 · see citing works
Genotoxicity of chloroquine in rat liver cells: Protective role of free radical scavengers
Farombi, E. O. (2006) · Cell Biology and Toxicology · doi:10.1007/s10565-006-0173-2 · Cited by 42 · see citing works
Son, Y., Lee, K., Kook, S., Lee, J., Kim, J., Jeon, Y., & Jang, Y. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.09.012 · Cited by 39 · see citing works
In vitro basal and metabolism-mediated cytotoxicity of flavonoids
Soares, V. C. G., Varanda, E. A., & Raddi, M. S. G. (2005) · Food and Chemical Toxicology · doi:10.1016/j.fct.2005.11.006 · Cited by 38 · see citing works
Antioxidant activity: what do we measure?
Bartosz, G., & Bartosz, M. (1999) · Acta Biochimica Polonica · doi:10.18388/abp.1999_4180 · Cited by 32 · see citing works
Self-citationFlow cytometry analysis of atherosclerotic plaque cells from human carotids: a validation study
Bonanno, E., Mauriello, A., Partenzi, A., Anemona, L., & Spagnoli, L. G. (2000) · Cytometry · doi:10.1002/(sici)1097-0320(20000201)39:2 · Cited by 29 · see citing works
Rice-Evans, C. A., Diplock, A. T., & Symons, M. C. R. (1991) · Laboratory techniques in biochemistry and molecular biology · doi:10.1016/s0075-7535(08)70040-8 · Cited by 21 · see citing works
Tv, S. (1999) · PubMed · Cited by 19 · see citing works
Coadjustment of quercetin and hydrogen peroxide: the role of ROS in the cytotoxicity of quercetin.
Chen, J., Yingxian, O., Da, W.-M., & Kang, J. (2004) · PubMed · Cited by 14 · see citing works
Gakhramanov, F. S. (2005) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-005-0469-x · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Bartosz G., 2003, The other face of oxygen. Free radicals in nature
Cited by
Sorted by citations
Bouayed, J., & Bohn, T. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.4.12858 · Cited by 1,095 · see citing works
“In this regard, recent studies employing cell models have highlighted the prooxidative activity of several polyphenols already known as antioxidants such as quercetin, catechins including epicatechin and epigallocatechin-3-gallate (EGCG) and gallic acid.50-55 For example, at high doses, it has been demonstrated that q…”
BackgroundInfluentialMultitargeted cancer prevention by quercetin
Murakami, A., Ashida, H., & Terao, J. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.046 · Cited by 729 · see citing works
Biancatelli, R. M. L. C., Berrill, M., Catravas, J. D., & Marik, P. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01451 · Cited by 512 · see citing works
“Studies suggest that quercetin supplementation may promote antioxidant (9), antiinflammatory, antiviral (10), and immunoprotective effects (11).”
BackgroundSrivastava, S., Somasagara, R. R., Hegde, M. B., Nishana, M., Tadi, S. K., Srivastava, M., Choudhary, B., & Raghavan, S. C. (2016) · Scientific Reports · doi:10.1038/srep24049 · Cited by 484 · see citing works
Quercetin and Cancer Chemoprevention
Gibellini, L., Pinti, M., Nasi, M., Montagna, J. P., Biasi, S. D., Roat, E., Bertoncelli, L., Cooper, E. L., & Cossarizza, A. (2010) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/neq053 · Cited by 453 · see citing works
“Similar effects on the cell cycle have also been reported in SW872 cells [112].”
BackgroundQuercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry
Wu, W., Li, R., Li, X., He, J. G., Jiang, S., Liu, S., & Yang, J. W. (2015) · Viruses · doi:10.3390/v8010006 · Cited by 427 · see citing works
“Numerous experiments have shown that quercetin exerts antiproliferative [20], antioxidative [21], antibacterial [22], anticancer [23] and antiviral [24] effects.”
BackgroundAntiproliferative Effects of Honey and of Its Polyphenols: A Review
Jaganathan, S. K., & Mandal, M. (2009) · BioMed Research International · doi:10.1155/2009/830616 · Cited by 316 · see citing works
“They also found incubating with low concentrations of quercetin led to a small increase in Total Antioxidant Capacity (TAC) of cell extracts but higher concentrations of the quercetin led to a progressive decrease in the TAC of cell extracts.”
BackgroundInfluentialMolecular Targets Underlying the Anticancer Effects of Quercetin: An Update
Khan, F., Niaz, K., Maqbool, F., Hassan, F. I., Abdollahi, M. R., Venkata, K. C. N., Nabavi, S. M., & Bishayee, A. (2016) · Nutrients · doi:10.3390/nu8090529 · Cited by 287 · see citing works
Youl, E., Bardy, G., Magous, R., Cros, G. H., Sejalon, F., Virsolvy, A., Richard, S., Quignard, J., Gross, R., Petit, P., et al. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00910.x · Cited by 259 · see citing works
“Finally, the fact that quercetin was able to inhibit glucose-induced insulin secretion in the INS-1 cells at a concentration 10-fold higher than that displaying insulin secretion potentiation (200 mmol·L-1) raises the possibility of a toxicity linked to prooxidant effects, as recently described on human non-small lung…”
BackgroundPérez-Torres, I., Guarner‐Lans, V., & Rubio-Ruiz, M. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102098 · Cited by 252 · see citing works
Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions
Suganthy, N., Devi, K. P., Nabavi, S. F., Braidy, N., & Nabavi, S. M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.011 · Cited by 236 · see citing works
Antioxidant dietary approach in treatment of fatty liver: New insights and updates
Ferramosca, A., Giacomo, M. D., & Zara, V. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i23.4146 · Cited by 180 · see citing works
Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets
Pratheeshkumar, P., Sreekala, C., Zhang, Z., Budhraja, A., Ding, S., Son, Y., Wang, X., Hitron, J. A., Hyun-Jung, K., Wang, L., et al. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012803833035 · Cited by 178 · see citing works
“Quercetin at lower concentration enhanced the cancer cell prolifearation whereas at higher concentrations showed the concentration dependent cytotoxicity [99].”
BackgroundSite-Specific Anticancer Effects of Dietary Flavonoid Quercetin
Sak, K. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2014.864418 · Cited by 170 · see citing works
Antioxidant Properties of Honey and Its Role in Preventing Health Disorder
Khalil, M. I., Sulaiman, S. A., & Boukraâ, L. (2010) · The Open Nutraceuticals Journal · doi:10.2174/18763960010030100006 · Cited by 165 · see citing works
“It has been reported that quercetin in low concentration promoted cell proliferation of A-549 cells, whereas in higher concentration it inhibited cell proliferation and survival [43].”
Tchantchou, F., Lacor, P. N., Cao, Z., Lao, L., Hou, Y., Cui, C., Klein, W. L., & Luo, Y. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1189 · Cited by 163 · see citing works
“This biphasic effect of quercetin was also demonstrated by others, which show the phosphorylation of CREB at low dose and cytotoxicity at higher ones [40,53,54].”
BackgroundMesoporous silica as topical nanocarriers for quercetin: characterization and in vitro studies
Sapino, S., Ugazio, E., Gastaldi, L., Miletto, I., Berlier, G., Zonari, D., & Oliaro‐Bosso, S. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.11.022 · Cited by 160 · see citing works
“Growth inhibition at concentrations ranging from 50 lM to 100 lM was also observed in different cancer cell lines [9,67,68], while the toxicity of Q in normal, non tumor cells, was detected at concentrations higher than 100 lM [10].”
BackgroundCancer Chemoprevention: A Strategic Approach Using Phytochemicals
Mohan Shankar, G., Swetha, M., Keerthana, C. K., Rayginia, T. P., & Anto, R. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.809308 · Cited by 142 · see citing works
Chang, J., Lai, S.-L., Chen, W.-S., Hung, W.-Y., Chow, J., Hsiao, M., Lee, W.-J., & Chien, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.06.017 · Cited by 129 · see citing works
“The decrease in the intracellular glutathione (GSH) concentration was demonstrated in response to very different apoptotic stimuli, including quercetin-induced cell death in lung cancer [22].”
BackgroundMechanism of antioxidant properties of quercetin and quercetin-DNA complex
Song, X., Wang, Y., & Gao, L. (2020) · Journal of Molecular Modeling · doi:10.1007/s00894-020-04356-x · Cited by 129 · see citing works
Flavonoids: Potential Wnt/beta-catenin signaling modulators in cancer
Amado, N. G., Fonseca, B. F., Cerqueira, D. M., Neto, V. M., & Abreu, J. G. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.05.003 · Cited by 125 · see citing works
Xu, W., Lu, H., Yuan, Y., Deng, Z., Zheng, L., & Li, H. (2022) · Foods · doi:10.3390/foods11162439 · Cited by 122 · see citing works
“Moreover, higher concentrations of the flavonoid diminished cell viability and total antioxidant capacity, as well as the activities of catalase, superoxide dismutase, and glutathione S-transferase [57].”
BackgroundQuercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission
Cui, L., Li, Z., Chang, X., Cong, G., & Hao, L. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.11.006 · Cited by 120 · see citing works
Rutin and Total Quercetin Content in Amaranth (Amaranthus spp.)
Kalinová, J., & Dadáková, E. (2008) · Plant Foods for Human Nutrition · doi:10.1007/s11130-008-0104-x · Cited by 119 · see citing works
“Both compounds, rutin and quercetin, are important antioxidants that significantly inhibit the oxidation of HDL cholesterol [ 19 ].”
BackgroundAlam, M., Alam, S., Shamsi, A., Adnan, M., Elasbali, A. M., Al‐Soud, W. A., Alreshidi, M. M., Hawsawi, Y. M., Tippana, A., Pasupuleti, V. R., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.869672 · Cited by 118 · see citing works
Pandey, S. K., Patel, D. K., Thakur, R. K., Mishra, D. P., Maiti, P., & Haldar, C. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.02.011 · Cited by 106 · see citing works
Lee, W.-J., Hsiao, M., Chang, J.-L., Yang, S., Tseng, T., Cheng, C., Chow, J., Lin, K.-H., Lin, Y.-W., Liu, C.-C., et al. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1300-0 · Cited by 106 · see citing works
“1998); whereas, it was also reported to be an antioxidant (De Marchi et al. 2009; Robaszkiewicz et al. 2007).”
Mostafavi‐Pour, Z., Ramezani, F., Keshavarzi, F., & Samadi, N. (2017) · Oncology Letters · doi:10.3892/ol.2017.5619 · Cited by 100 · see citing works
“By contrast, low doses of Q augment the total antioxidant capacity of cancer cells and counteract the cytotoxic effects of antineoplastic drugs in lung cancer A549, colorectal cancer HCT116 and ovarian cancer cells (22).”
RetractedQuercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo
Hu, X., Ding, C., Zhou, N., & Chen, X. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.007 · Cited by 96 · see citing works
Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92 · see citing works
Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2‐deoxyglucose and etomoxir
Hernlund, E., Ihrlund, L. S., Khan, O. M., Ateş, Y. Ö., Linder, S. T., Panaretakis, T., & Shoshan, M. C. (2008) · International Journal of Cancer · doi:10.1002/ijc.23525 · Cited by 91 · see citing works
Fan, J.-J., Hsu, W.-H., Lee, K., Chen, K., Lin, C., Lee, Y.-L., Ko, T., Lee, L.-T., Lee, M., Chang, M.-S., et al. (2019) · Antioxidants · doi:10.3390/antiox8110557 · Cited by 90 · see citing works
Kandeil, A., Mostafa, A., Kutkat, O., Moatasim, Y., Al-Karmalawy, A. A., Rashad, A. A., Kayed, A. E., Kayed, A. E., El‐Shesheny, R., Kayali, G., et al. (2021) · Pathogens · doi:10.3390/pathogens10060758 · Cited by 90 · see citing works
“Quercetin has several therapeutic properties including antioxidant [15], antibacterial [16], anticancer [17], and antiviral effects [18,19].”
BackgroundLewińska, A., Adamczyk‐Grochala, J., Kwasniewicz, E., Deręgowska, A., & Wnuk, M. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.11.018 · Cited by 90 · see citing works
Li, N., Sun, C., Zhou, B., Xing, H., Ma, D., Chen, G., & Weng, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100314 · Cited by 89 · see citing works
“found that Quercetin at concentrations of 5 mM and 10 mM could increase the efficacy of 100 mM doxorubicin in breast cancer cells in vitro [17,18], while other researchers came to different conclusions [8,9].”
BackgroundResultDiosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line
Lewińska, A., Siwak, J., Rzeszutek, I., & Wnuk, M. (2014) · Toxicology in Vitro · doi:10.1016/j.tiv.2014.12.005 · Cited by 88 · see citing works
“Low concentrations of quercetin stimulated cell proliferation and increased total antioxidant capacity (TAC) of the cells; whilst higher concentrations of quercetin decreased cell survival and viability, thiol content, TAC and activities of superoxide dismutase, catalase and glutathione S-transferase (Robaszkiewicz et…”
BackgroundOral administration of quercetin inhibits bone loss in rat model of diabetic osteopenia
Liang, W., Luo, Z., Ge, S., Li, M., Du, J., Yan, M., Yan, M., Ye, Z., & Luo, Z. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.08.014 · Cited by 87 · see citing works
“(ALP) activity in MG-63 osteoblasts (Robaszkiewicz et al., 2007).”
The protective role of plant biophenols in mechanisms of Alzheimer's disease
Omar, S. H., Scott, C., Hamlin, A. S., & Obied, H. K. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.02.016 · Cited by 82 · see citing works
“In another study, quercetin showed opposing activities based on its concentration and position [144].”
BackgroundAnti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression
Varghese, E., Líšková, A., Kubatka, P., Samuel, S. M., & Büsselberg, D. (2020) · Biomolecules · doi:10.3390/biom10020191 · Cited by 80 · see citing works
“1–20 μM) while showing pro‐oxidant activity at a higher dose (> 50 μM) in relation to glutathion concentration and super oxide dismutase activity as tested in A549 cells [142].”
BackgroundGalluzzo, P., Martini, C., Bulzomi, P., Leone, S., Bolli, A., Pallottini, V., & Marino, M. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800239 · Cited by 80 · see citing works
“, urate, ascorbate and tocopherols) act as antioxidants in vivo and consequently lower the incidence of some diseases [35–39].”
BackgroundQuercetin solid lipid microparticles: A flavonoid for inhalation lung delivery
Scalia, S., Haghi, M., Losi, V., Trotta, V., Young, P. M., & Traini, D. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.03.009 · Cited by 79 · see citing works
Potential harms of supplementation with high doses of antioxidants in athletes
Li, S., Fasipe, B., & Laher, I. (2022) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2022.06.001 · Cited by 78 · see citing works
Hatahet, T., Morille, M., Shamseddin, A., Aubert‐Pouëssel, A., Devoisselle, J., & Bégu, S. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.12.043 · Cited by 77 · see citing works
Henríquez, G., Gomez, A., Guerrero, E., & Narayan, M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00381 · Cited by 83 · see citing works
Effects of quercetin on oxidative stress and memory retrieval in kindled rats
Nassiri‐Asl, M., Moghbelinejad, S., Abbasi, E., Yonesi, F., Haghighi, M.-R., Lotfizadeh, M., & Bazahang, P. (2013) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.04.019 · Cited by 75 · see citing works
“Thus, it has been suggested that quercetin has complex oxidative and antioxidative effects [40].”
BackgroundMansour, S. M., Bahgat, A. K., El-Khatib, A. S., & Khayyal, M. T. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.01.014 · Cited by 75 · see citing works
Liposomal quercetin: evaluating drug deliveryin vitroand biodistributionin vivo
Wang, G., Jie, W. J., Zhang, P., Ming, D., Ying, L. J., Wang, L., & Ye, F. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.679926 · Cited by 75 · see citing works
“QUE contains both antioxidant and pro-oxidant properties; thus, in different cellular models low concentrations of QUE induce cell proliferation and increase the antioxidant capacity of the cells, whereas higher concentrations of QUE decrease antioxidant capacity and thiol content, ultimately causing cell death [5].”
BackgroundLinking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal
Romano, A., Serviddio, G., Calcagnini, S., Villani, R., Giudetti, A. M., Cassano, T., & Gaetani, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.046 · Cited by 77 · see citing works
Gadacha, W., Ben‐Attia, M., Bonnefont‐Rousselot, D., Aouani, E., Ghanem‐Boughanmi, N., & Touitou, Y. (2009) · Redox Report · doi:10.1179/135100009x466131 · Cited by 74 · see citing works
Mahbub, A. A., Maitre, C. L. L., Haywood‐Small, S., McDougall, G. J., Cross, N. A., & Jordan, N. (2013) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/18715206113139990303 · Cited by 73 · see citing works
“M), in breast (MDA-MB-231 and MDA-MB-453 [29, 30], MCF-7 [31]), cervical (HeLa) [32-34], liver (HepG2) [35], lung (A-549) [36] and leukemia cell lines (HL-60 and K562) [17, 37].”
Chen, R., Lin, J., Hong, J., Han, D., Zhang, A. D., Lan, R., Fu, L., Wu, Z., Lin, J., Zhang, W., et al. (2014) · Toxicology Reports · doi:10.1016/j.toxrep.2014.07.014 · Cited by 73 · see citing works
UVA and UVB radiation-induced oxidation products of quercetin
Fahlman, B. M., & Krol, E. S. (2009) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2009.08.009 · Cited by 73 · see citing works
Khadrawy, O., Gebremedhn, S., Salilew‐Wondim, D., Taqi, M. O., Neuhoff, C., Tholen, E., Hoelker, M., Schellander, K., & Tesfaye, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071635 · Cited by 69 · see citing works
“The antioxidant activity of Que was reported at low concentration, while higher concentrations resulted in decrease cellular proliferation as a result of induced apoptosis [96], stimulate the generation of superoxide radicals (O2) and subsequently affecting mitochondrial activity [97].”
BackgroundOršolić, N., Goluža, E., Đikić, D., Lisičić, D., Sašilo, K., Rođak, E., Jeleč, Ž., Lazarus, M. V., & Orct, T. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0622-7 · Cited by 69 · see citing works
Quercetin attenuates, indomethacin-induced acute gastric ulcer in rats
Al-Kushi, A. G., & ElSawy, N. A. (2016) · Folia Morphologica · doi:10.5603/fm.a2016.0067 · Cited by 67 · see citing works
“Studies have shown that daily intake of quercetin may decrease the risks of cardiovascular diseases [39], tumour development, strokes and neurodegenerative diseases [53] by protection against oxidative DNA damage [21], lipid peroxidation [38] and inhibition of the release of inflammatory mediators [41].”
BackgroundHatahet, T., Morille, M., Hommoss, A., Devoisselle, J., Müller, R. H., & Bégu, S. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.03.019 · Cited by 67 · see citing works
“This higher viability percentage was previously observed with crude quercetin on A549 cells especially at a low dose of quercetin (Robaszkiewicz et al., 2007).”
BackgroundEffects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells.
Cumaoğlu, A., Račková, L., Štefek, M., Kartal, M., Maechler, P., & Karasu, Ç. (2011) · Acta Biochimica Polonica · doi:10.18388/abp.2011_2284 · Cited by 66 · see citing works
“These polyphenols have been shown to decrease production of ROS in the cells but also trigger the production of peroxides in the medium in the presence of H2O2 (Raza & John, 2005; Robaszkiewicz et al., 2007).”
BackgroundHu, J., Yu, Q., Zhao, F., Ji, J., Jiang, Z., Chen, X., Gao, P. J., Ren, Y., Shao, S., Zhang, L., et al. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.08.004 · Cited by 66 · see citing works
Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by Quercetin
Li, Z., Cao, H., Cheng, Y., Zhang, X., Zeng, W., Sun, Y., Chen, S., He, Q., & Han, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218095 · Cited by 65 · see citing works
“Previous studies have reported that quercetin possesses antioxidative [8], anticancer [9], antibacterial [10], and antiviral [11] effects.”
BackgroundPro-oxidant activity of apocynin radical
Castor, L. R. G., Locatelli, K. A., & Ximenes, V. F. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.010 · Cited by 63 · see citing works
Ishii, T., Ishikawa, M., Miyoshi, N., Yasunaga, M., Akagawa, M., Uchida, K., & Nakamura, Y. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900148k · Cited by 63 · see citing works
Roshchupkina, G. I., Bobko, A. A., Bratasz, A., Резников, В. А., Kuppusamy, P., & Khramtsov, V. V. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.019 · Cited by 63 · see citing works
Fabiani, R., Fuccelli, R., Pieravanti, F., Bartolomeo, A. D., & Morozzi, G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800376 · Cited by 62 · see citing works
Dual Effects ofGinkgo bilobaLeaf Extract on Human Red Blood Cells
He, J., Lin, J., Li, J., Zhang, J., Sun, X., & Zeng, C. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00354.x · Cited by 62 · see citing works
Multitarget Effects of Quercetin in Leukemia
Maso, V., Calgarotto, A. K., Franchi, G. C., Nowill, A. E., Filho, P. L., Vassallo, J., & Saad, S. T. O. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0383 · Cited by 61 · see citing works
“The antioxidant and anti-inflammatory properties of quercetin have been associated with the amelioration of adverse side effects derived from cancer therapy, which is considered a good strategy to prevention and treatment of cancer (27).”
BackgroundAntiaging effects of dietary supplements and natural products
Gao, L., Liu, X., Luo, X., Lou, X., Li, P., Li, X., & Liu, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1192714 · Cited by 60 · see citing works
“1–10 μM) and decrease in thiol content, total antioxidant capacity, cell proliferation, and induction of cell apoptosis and necrosis at higher concentrations of the quercetin (>50 mM) (Robaszkiewicz et al., 2007).”
BackgroundDurgo, K., Belščak‐Cvitanović, A., Stančić, A., Franekić, J., & Komes, D. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2011.0087 · Cited by 60 · see citing works
“49 In our previous study, 50 we had shown that constitutive levels of GSH are higher in cisplatin-resistant CK2 cells of laryngeal carcinoma than in the parental HEp2 cells, but also that quercetin induces a significant increase in the GSH levels of both cell lines, again pointing toward the…”
Overview of biological effects of Quercetin on ovary
Rashidi, Z., Khosravizadeh, Z., Talebi, A., Khodamoradi, K., Ebrahimi, R., & Amidi, F. (2020) · Phytotherapy Research · doi:10.1002/ptr.6750 · Cited by 59 · see citing works
Xing, Z., Meng, W., Yuan, J., Moon, S., Jeong, Y., & Kang, I. (2012) · Journal of Nanomaterials · doi:10.1155/2012/202608 · Cited by 58 · see citing works
Martinelli, E., Granato, D., Azevedo, L. C., Gonçalves, J. E., Lorenzo, J. M., Munekata, P. E. S., Simal‐Gándara, J., Barba, F. J., Carrillo, C., Rajoka, M. S. R., et al. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.07.024 · Cited by 57 · see citing works
Khan, A. P., Iqtadar, S., Mumtaz, S. U., Heinrich, M., Pascual-Figal, D. A., Livingstone, S. J., & Abaidullah, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.898062 · Cited by 55 · see citing works
“Extensive in vivo studies have revealed the anti-inflammatory, antiviral, immunoprotective, and antioxidant effects of quercetin (Nair et al., 2002; Robaszkiewicz et al., 2007; Uchide and Toyoda, 2011; Colunga Biancatelli et al., 2020; Salehi et al., 2020).”
BackgroundKusaczuk, M., Krętowski, R., Naumowicz, M., Stypułkowska, A., & Cechowska‐Pasko, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031345 · Cited by 54 · see citing works
“, as an antioxidant scavenging free radicals and preventing apoptosis and as a pro-oxidative agent decreasing levels of glutamate-stimulating hormones (GSH) and facilitating apoptosis) [44].”
BackgroundAbarikwu, S. O., Pant, A. B., & Farombi, E. O. (2012) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21449 · Cited by 54 · see citing works
“On the other hand, QT can also exhibit prooxidant effects [4].”
BackgroundRole of flavonoids against adriamycin toxicity
Navarro‐Hortal, M. D., Varela‐López, A., Romero‐Márquez, J. M., Rivas‐García, L., Speranza, L., Battino, M. A., & Quiles, J. L. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111820 · Cited by 52 · see citing works
Ulla, A., Uchida, T., Miki, Y., Sugiura, K., Higashitani, A., Kobayashi, T., Ohno, A., Nakao, R., Hirasaka, K., Sakakibara, I., et al. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108873 · Cited by 55 · see citing works
A review of propolis antitumour action in vivo and in vitro
Oršolić, N. (2010) · Journal of ApiProduct and ApiMedical Science · doi:10.3896/ibra.4.02.1.01 · Cited by 51 · see citing works
Nrf2 Expression and Apoptosis in Quercetin-treated Malignant Mesothelioma Cells
Lee, Y.-J., Lee, D. M., & Lee, S.-H. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.2268 · Cited by 49 · see citing works
“cells and antagonized the cytotoxic effects of antineoplastic agents in lung cancer A549, colorectal cancer HCT116, and ovarian cancer cells (Li et al., 2014; Robaszkiewicz et al., 2007; Samuel et al, 2012).”
BackgroundOrtega, R., & Garcı́a, N. (2009) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-009-9198-6 · Cited by 49 · see citing works
“The controversy is based on the characteristics exhibited by flavonoids as antioxidants and pro-oxidants (Cano et al. 2002; Sekher Pannala et al. 2001; Robaszkiewicz et al. 2007).”
Guo, C., Bi, J., Li, X., Lyu, J., Liu, X., Wu, X., & Liu, J. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127931 · Cited by 48 · see citing works
Ossola, B., Kääriäinen, T. M., Raasmaja, A., & Männistö, P. T. (2008) · Toxicology · doi:10.1016/j.tox.2008.04.001 · Cited by 48 · see citing works
Influence of polyphenols on Escherichia coli resistance to oxidative stress
Smirnova, G. V., Samoilova, Z., Muzyka, N. G., & Oktyabrsky, O. N. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.017 · Cited by 47 · see citing works
González-Esquivel, A. E., Charles-Niño, C. L., Pacheco-Moisés, F. P., Ortíz, G. G., Jaramillo‐Juárez, F., & Rincón‐Sánchez, A. R. (2015) · Toxicology Mechanisms and Methods · doi:10.3109/15376516.2015.1006491 · Cited by 46 · see citing works
A Review on Antiproliferative and Apoptotic Activities of Natural Honey
Jaganathan, S. K., Balaji, A., Vellayappan, M. V., Asokan, M., Subramanian, A., John, A., Supriyanto, E., Razak, S. I. A., & Marvibaigi, M. (2014) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520614666140722084747 · Cited by 46 · see citing works
Zubčić, K., Radovanović, V., Vlainić, J., Hof, P. R., Oršolić, N., Šimić, G., & Jembrek, M. J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9834742 · Cited by 46 · see citing works
“Furthermore, depending on the dose, it may exert antioxidative as well as prooxidative effects [33].”
BackgroundResultThe Stability and Antioxidant Activity of Anthocyanins from Blueberry
He, R., Li, Z. M., & Wang, B. C. (2010) · University of Zagreb University Computing Centre (SRCE) · Cited by 45 · see citing works
García‐Rodríguez, M. D. C., Nicolás-Méndez, T., Montaño-Rodriguez, A., & Altamirano-Lozano, M. A. (2014) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2013.865006 · Cited by 43 · see citing works
“Studies demonstrated that flavonoids such as quercetin may exert pro-oxidant damage in vivo (Mazumdar et al., 2011) and in vitro (Boots et al., 2007; Resende et al., 2012; Robaszkiewicz et al., 2007).”
BackgroundBekhet, O. H., & Eid, M. E. (2021) · Translational Cancer Research · doi:10.21037/tcr-21-629 · Cited by 45 · see citing works
“, quercetin at higher concentrations (>50 μM) can initiate ROS generation especially O2 ; and in another study, it was observed to decrease cell viability, and TAC (77).”
BackgroundAngiogenic and osteogenic effects of flavonoids in bone regeneration
Shanmugavadivu, A., Balagangadharan, K., & Selvamurugan, N. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28162 · Cited by 42 · see citing works
“Quercetin showed a wide range of bioactivities such as antioxidant (Robaszkiewicz et al., 2007), antiviral (Uchide & Toyoda, 2011), anti‐inflammatory (Lesjak et al., 2017), and immunoprotective effects (Nair et al., 2002).”
BackgroundFlavonoids: Precipitation Kinetics and Interaction with Surfactant Micelles
Löf, D., Schillén, K., & Nilsson, L. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02103.x · Cited by 42 · see citing works
Strugała, P., Gładkowski, W., Kucharska, A. Z., Sokół‐Łętowska, A., & Gabrielska, J. (2015) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201500001 · Cited by 42 · see citing works
Inhibition of Nrf2 enhances the anticancer effect of 6-O-angeloylenolin in lung adenocarcinoma
Wang, Y., Yu, R., Zhang, J., Zhang, W., Huang, Z., Hu, H., Li, Y.-L., Li, B., & He, Q. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.01.006 · Cited by 40 · see citing works
Önal, H., Arslan, B., Ergun, N. Ü., Topuz, H. Ş., Semerci, S. Y., KURNAZ, M. E., Yulet Miray, M. O. L. U., Bozkurt, M. A., Suner, N., & Kocataş, A. (2021) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-2104-16 · Cited by 40 · see citing works
“Quercetin, as a widely available plant flavonoid, has antioxidant, anti-inflammatory, antiviral and immunoprotective effects (Nair et al., 2002; Robaszkiewicz et al., 2007; Uchide et al., 2011).”
BackgroundSiddiqui, S., Ahmad, E., Gupta, M., Rawat, V., Shivnath, N., Banerjee, M., Khan, M. S., & Arshad, M. (2015) · Cell Proliferation · doi:10.1111/cpr.12195 · Cited by 40 · see citing works
Fernández-Blanco, C., Font, G., & Ruiz, M.-J. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.01.011 · Cited by 39 · see citing works
Complementary and Alternative Medicine Use in Radiotherapy: What Are Patients Using?
Gillett, J., Ientile, C. S., Hiscock, J., Plank, A. W., & Martin, J. M. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2011.0334 · Cited by 39 · see citing works
“It should also be acknowledged that antioxidant compounds, such as quercetin 22 and the lipophilic derivative of vitamin C 23 may act as prooxidants depending on the concentration taken.”
Wang, G., Wang, J., Luo, J. D., Wang, L., Chen, X.-L., Zhang, L., & Jiang, S. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34607 · Cited by 38 · see citing works
RetractedIsoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status
Sun, C., Zhang, H., Ma, X., Zhou, X. H., Gan, L., Liu, Y.-Y., & Wang, Z. (2012) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-012-9447-x · Cited by 37 · see citing works
Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models
Nassiri‐Asl, M., Hajiali, F., Taghiloo, M., Abbasi, E., Mohseni, F., & Yousefi, F. (2014) · Toxicology and Industrial Health · doi:10.1177/0748233713518603 · Cited by 37 · see citing works
“Subsequently, it has been suggested that quercetin has complex oxidative and antioxidative effects (Robaszkiewicz et al., 2007).”
BackgroundNwokocha, C. R., Baker, A., Douglas, D., McCalla, G., Nwokocha, M., & Brown, P. D. (2013) · Cardiovascular Toxicology · doi:10.1007/s12012-013-9216-0 · Cited by 36 · see citing works
“[33] and may underlie some of the recent findings regarding beneficial and/or deleterious effects of this chemical as well as others with pro-oxidant characteristics [34, 35].”
Kaempferol inhibits Entamoeba histolytica growth by altering cytoskeletal functions
Bolaños, V., Díaz-Martínez, A., Soto‐Sánchez, J., Marchat, L. A., Monroy, V. S., & Ramírez‐Moreno, E. (2015) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2015.11.004 · Cited by 38 · see citing works
- Authors
- Robaszkiewicz, A., Balcerczyk, A., & Bartosz, G.
- Affiliations
- University of Łódź (PL)
- Corresponding author
- Robaszkiewicz, Agnieszka
- Venue
- Cell Biology International
- Publisher
- Wiley
- Published
- 2007-10
- Volume
- 31
- Issue
- 10
- Pages
- 1245-1250
- ISSN
- 1065-6995 (ISSN-L)
- 1095-8355
- OpenAlex
- W2086381409
- Cited by
- 279
- References
- 46
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 16 · 2022: 31 · 2021: 25 · 2020: 23 · 2019: 9 · 2018: 10 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 17
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell Biology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- quercetin, flavonoids, plant polyphenols, A549 cells, lung epithelial cells, antioxidant capacity, pro-oxidant activity, oxidative stress, reactive oxygen species, superoxide dismutase, catalase, glutathione S-transferase, thiol content, cell proliferation, cell viability, peroxide formation
- MeSH terms
- Antioxidants, Carcinoma, Non-Small-Cell Lung, Catalase, Glutathione Transferase, Humans, Lung Neoplasms, Quercetin, Sulfhydryl Compounds, Superoxide Dismutase, Tumor Cells, Cultured, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
