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The immune response to Prevotella bacteria in chronic inflammatory disease
Open accessAbstract
The microbiota plays a central role in human health and disease by shaping immune development, immune responses and metabolism, and by protecting from invading pathogens. Technical advances that allow comprehensive characterization of microbial communities by genetic sequencing have sparked the hunt for disease-modulating bacteria. Emerging studies in humans have linked the increased abundance of Prevotella species at mucosal sites to localized and systemic disease, including periodontitis, bacterial vaginosis, rheumatoid arthritis, metabolic disorders and low-grade systemic inflammation. Intriguingly, Prevotella abundance is reduced within the lung microbiota of patients with asthma and chronic obstructive pulmonary disease. Increased Prevotella abundance is associated with augmented T helper type 17 (Th17) -mediated mucosal inflammation, which is in line with the marked capacity of Prevotella in driving Th17 immune responses in vitro. Studies indicate that Prevotella predominantly activate Toll-like receptor 2, leading to production of Th17-polarizing cytokines by antigen-presenting cells, including interleukin-23 (IL-23) and IL-1. Furthermore, Prevotella stimulate epithelial cells to produce IL-8, IL-6 and CCL20, which can promote mucosal Th17 immune responses and neutrophil recruitment. Prevotella-mediated mucosal inflammation leads to systemic dissemination of inflammatory mediators, bacteria and bacterial products, which in turn may affect systemic disease outcomes. Studies in mice support a causal role of Prevotella as colonization experiments promote clinical and inflammatory features of human disease. When compared with strict commensal bacteria, Prevotella exhibit increased inflammatory properties, as demonstrated by augmented release of inflammatory mediators from immune cells and various stromal cells. These findings indicate that some Prevotella strains may be clinically important pathobionts that can participate in human disease by promoting chronic inflammation.
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“In vitro experiments have shown that Prevotella can stimulate the production of IL-8, IL-6, and CCL20 in lung epithelial cells, which promotes mucosal Th17 immune response and neutrophil recruitment (Larsen, 2017).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Larsen, 2017
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“In vitro experiments have shown that Prevotella can stimulate the production of IL-8, IL-6, and CCL20 in lung epithelial cells, which promotes mucosal Th17 immune response and neutrophil recruitment (Larsen, 2017).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Larsen, 2017
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Tett, A., Pasolli, E., Masetti, G., Ercolini, D., & Segata, N. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-021-00559-y · Cited by 748
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Metadata
- Authors
- Larsen, J. M.
- Affiliations
- Metropolitan University College (DK)
- Corresponding author
- Larsen, Jeppe Madura
- ORCID
- Larsen, Jeppe Madura
- Venue
- Immunology
- Publisher
- Wiley
- Published
- 2017-06-20
- Volume
- 151
- Issue
- 4
- Pages
- 363-374
- ISSN
- 0019-2805 (ISSN-L)
- 1365-2567
- PMC
- PMC5506432
- OpenAlex
- W2618503740
- Cited by
- 1,343
- References
- 105
- Citations by year
- 2026: 118 · 2025: 219 · 2024: 245 · 2023: 170 · 2022: 190 · 2021: 165 · 2020: 116 · 2019: 78 · 2018: 34 · 2017: 8
- FWCI
- 9.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Immunology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- Prevotella, gut microbiota, chronic inflammation, Th17 cells, mucosal inflammation, TLR2, IL-23, interleukin-1, interleukin-8, CCL20, neutrophil recruitment, asthma, chronic obstructive pulmonary disease, periodontitis, bacterial vaginosis, rheumatoid arthritis, metabolic disorders, pathobionts, systemic inflammation
- MeSH terms
- Animals, Chronic Disease, Humans, Immunity, Inflammation, Intestinal Mucosa, Cytokines, Bacteroidaceae Infections, Prevotella, Toll-Like Receptor 2, Immunomodulation, Th17 Cells, High-Throughput Nucleotide Sequencing, Microbiota
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