Cited by 748Gut microbiota and healthOral microbiology and periodontitis researchMicrobial Community Ecology and Physiology

Prevotella Diversity, Niches and Interactions with the Human Host

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Tett, Adrian, Pasolli, Edoardo, Masetti, Giulia, Ercolini, Danilo, Segata, Nicola·2021·Nature Reviews Microbiology

Abstract

The genus Prevotella includes more than 50 characterized species that occur in varied natural habitats, although most Prevotella spp. are associated with humans. In the human microbiome, Prevotella spp. are highly abundant in various body sites, where they are key players in the balance between health and disease. Host factors related to diet, lifestyle and geography are fundamental in affecting the diversity and prevalence of Prevotella species and strains in the human microbiome. These factors, along with the ecological relationship of Prevotella with other members of the microbiome, likely determine the extent of the contribution of Prevotella to human metabolism and health. Here we review the diversity, prevalence and potential connection of Prevotella spp. in the human host, highlighting how genomic methods and analysis have improved and should further help in framing their ecological role. We also provide suggestions for future research to improve understanding of the possible functions of Prevotella spp. and the effects of the Western lifestyle and diet on the host-Prevotella symbiotic relationship in the context of maintaining human health.

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Crossref · 10.1038/s41579-021-00559-y

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  • The genus Prevotella, including P. denticola, acts on the early and middle steps of oral biofilm formation with cellular adhesion for later colonizers and supports the biofilm formation of Aggregatibacter actinomycetemcomitans.

    “The genus Prevotella, including P. denticola, acts on the early and middle steps of oral biofilm formation with cellular adhesion for later colonizers and, in particular, supports the biofilm formation of Aggregatibacter actinomycetemcomitans [22,23].”

    From Analysis of Chemical Structure and Antibiofilm Properties of Exopolysaccharides from Lactiplantibacillus plantarum EIR/IF-1 Postbiotics (2022) · cites this paper as [23]

    In “Prevotella in the oral cavity” (page not supplied), the review names P. denticola among species that may promote cell–cell adhesion in early and middle biofilm formation, and says Prevotella spp. can support Aggregatibacter actinomycetemcomitans. The citing sentence presents these qualified roles as established and does not distinguish the genus-level support for Aggregatibacter from the species named for early biofilm formation. (LLM, conf=0.83)

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Research works printed but not linked: 1

  1. [3]Shah HN, Chattaway MA, Rajakurana L. & Gharbia SE Prevotella. Bergey’s Manual of Systematics of Archaea and Bacteria 1– 25 (Springer, 2015).

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Authors
Tett, A., Pasolli, E., Masetti, G., Ercolini, D., & Segata, N.
Affiliations
  • University of Vienna (AT)
  • University of Naples Federico II (IT)
  • University of Trento (IT)
Corresponding author
  • Ercolini, Danilo
  • Segata, Nicola
Venue
Nature Reviews Microbiology
Published
2021-05-28
Volume
19
Issue
9
Pages
585-599
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W3165588742
Cited by
748
References
195
Citations by year
2026: 130 · 2025: 181 · 2024: 216 · 2023: 137 · 2022: 77 · 2021: 7
FWCI
12.25
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Iris (University of Trento) (submittedVersion, other-oa)
Funders
  • Joint Programming Initiative A healthy diet for a healthy life
  • Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN_2017, 20174FHBWR_005, H2020, RBFR13EWWI_001)
  • National Institutes of Health (1u01ca230551-01a1, 1U01CA230551)
  • Horizon 2020 Framework Programme (MASTER-818368, OncoBiome 825410, 818368, 825410)
  • National Cancer Institute (1U01CA230551, U01 CA230551, R01CA230551)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords
Prevotella, bacterial diversity, human microbiome, host-microbe interactions, gut microbiota, diet and microbiome, Western lifestyle, host-symbiont association
MeSH terms
Autoimmune Diseases, Humans, Phylogeny, Genetic Variation, Bacteroidaceae Infections, Prevotella, Microbiota

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