The DOI matches its Crossref record; 206 of the 206 references it cites were found in a registry or an index.
Release of mycobacterial antigens
Abstract
Summary: Mycobacterium tuberculosis has evolved from a Mycobacterium canettii‐like progenitor pool into one of the most successful and widespread human pathogens. The pathogenicity of M. tuberculosis is linked to its ability to secrete/export/release selected mycobacterial proteins, and it is also established that active release of mycobacterial antigens is a prerequisite for strong immune recognition. Recent research has enabled mycobacterial secretion systems and vesicle‐based release of mycobacterial antigens to be elucidated, which together with host‐related specificities constitute key variables that determine the outcome of infection. Here, we discuss recently discovered, novel aspects on the nature and the regulation of antigen release of the tuberculosis agent with particular emphasis on the biological characterization of mycobacteria‐specific ESX/type VII secretion systems and their secreted proteins, belonging to the Esx, PE, and PPE categories. The importance of specific mycobacterial antigen release is probably best exemplified by the striking differences observed between the cellular events during infection with the ESX‐1‐deficient, attenuated Mycobacterium bovis BCG compared to the virulent M. tuberculosis, which are clearly important for design of more specific diagnostics and more efficient vaccines.
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“In contrast, for ESX-1, ESX-3, and ESX-5, recent research has determined that they all contribute to virulence of M. tuberculosis, although the insights into the exact molecular functions often remain vague; also, because many studies have been undertaken with different mycobacterial species (M.tuberculosis, M. marinum, M. abscessus, and/or Mycobacterium smegmatis), which may show some species-”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [26]
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Sorted by citations
ESX secretion systems: mycobacterial evolution to counter host immunity
Gröschel, M. I., Sayes, F., Simeone, R., Majlessi, L., & Brosch, R. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.131 · Cited by 382
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Self-citationESAT-6–dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo
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Self-citation
Metadata
- Authors
- Majlessi, L., Prados‐Rosales, R., Casadevall, A., & Brosch, R.
- Affiliations
- Institut Pasteur (FR)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Brosch, Roland
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2015-02-20
- Volume
- 264
- Issue
- 1
- Pages
- 25-45
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2081816898
- Cited by
- 93
- References
- 206
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 8 · 2017: 9 · 2016: 17 · 2015: 10
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Community’s Framework Programme 7 (241745)
- Fondation pour la Recherche Médicale FRM (DEQ20130326471)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Keywords
- Mycobacterium tuberculosis, antigen secretion, ESX secretion system, type VII secretion system, ESX-1, Mycobacterium bovis BCG, virulence, host-pathogen interaction, tuberculosis vaccine, tuberculosis diagnosis
- MeSH terms
- SEC Translocation Channels, SecA Proteins, Adenosine Triphosphatases, Animals, Antigens, Bacterial, Bacterial Proteins, Biological Transport, Humans, Mycobacterium tuberculosis, Tuberculosis, Secretory Vesicles, Membrane Transport Proteins, Secretory Pathway, Bacterial Secretion Systems
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