The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Mechanisms involved in triggering rheumatoid arthritis
Abstract
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory syndrome with a strong autoimmune component. The autoantigens in RA are neither tissue nor organ‐specific, but comprise a broad collection of post‐translational modified proteins, such as citrullinated proteins. These modifications are likely to be triggered by innate stimuli. In genetically susceptible hosts, they can lead to a more substantiated secondary autoimmune reaction targeting the joints and precipitating the clinical onset of RA. Both innate and adaptive mechanisms will then closely interplay to promote chronic joint inflammation in the several absence of appropriate treatment. This scenario, is shared with other autoimmune diseases where potentially pathogenic immune responses are present already before disease onset. Better understanding of these processes will allow both earlier diagnosis of RA and identification of those healthy individuals that are at risk of developing disease, opening possibilities for disease prevention. In this review, we discuss the iterative processes of innate and adaptive immunity responsible for the (longitudinal) development of immune reactions that may contribute to the development of RA.
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“Circulating levels of IL-1, TNF, and IL-6 have often been found to peak during sleep or in the early morning hours (reviewed in Refs. 95, 321).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [95]
In the citing paper
“The production of many inflammatory markers varies across the 24-h day”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [95]
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1 retracted
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Cited by
Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“The immunopathology in RA is reasonably well understood and is characterized by inappropriate production of various cytokines, in particular TNF, among several other immunological abnormalities (94, 188).”
BackgroundPathogenetic insights from the treatment of rheumatoid arthritis
McInnes, I. B., & Schett, G. A. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31472-1 · Cited by 1,420
Immunopathogenesis of Rheumatoid Arthritis
Firestein, G. S., & McInnes, I. B. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.006 · Cited by 1,301
Horta‐Baas, G., Romero-Figueroa, M. D. S., Montiel-Jarquín, Á. J., Pizano-Zárate, M. L., Garcı́a-Mena, J., & Ramírez‐Durán, N. (2017) · Journal of Immunology Research · doi:10.1155/2017/4835189 · Cited by 337
Genetics of rheumatoid arthritis
Padyukov, L. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00912-0 · Cited by 219
Metadata
- Authors
- Catrina, A. I., Joshua, V., Klareskog, L., & Malmström, V.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Malmström, Vivianne
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2015-12-19
- Volume
- 269
- Issue
- 1
- Pages
- 162-174
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2211397752
- Cited by
- 160
- References
- 122
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 13 · 2021: 15 · 2020: 20 · 2019: 17 · 2018: 16 · 2017: 22 · 2016: 15 · 2015: 1
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Knut and Alice Wallenberg foundation
- Margareta af Ugglas foundation
- Swedish Research Council
- Swedish Cancer Society
- IMI consortia BTCure (115142-2)
- European Research Council (260167)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- rheumatoid arthritis, autoimmunity, citrullinated proteins, post-translational protein modification, innate immunity, adaptive immunity, autoantigens, joint inflammation, disease onset, early diagnosis, disease prevention, genetic susceptibility
- MeSH terms
- Animals, Arthritis, Rheumatoid, Autoantigens, Citrulline, Humans, Immunity, Innate, Protein Processing, Post-Translational, Disease Progression, Genetic Predisposition to Disease, Adaptive Immunity
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