Cited by 161Rheumatoid Arthritis Research and TherapiesNatural Compounds in Disease TreatmentAutoimmune and Inflammatory Disorders Research

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Mechanisms involved in triggering rheumatoid arthritis

Catrina, Anca I., Joshua, Vijay, Klareskog, Lars, Malmström, Vivianne·2016·Immunological Reviews

DOI 10.1111/imr.12379

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Abstract

Summary: Rheumatoid arthritis (RA) is a chronic inflammatory syndrome with a strong autoimmune component. The autoantigens in RA are neither tissue nor organ‐specific, but comprise a broad collection of post‐translational modified proteins, such as citrullinated proteins. These modifications are likely to be triggered by innate stimuli. In genetically susceptible hosts, they can lead to a more substantiated secondary autoimmune reaction targeting the joints and precipitating the clinical onset of RA. Both innate and adaptive mechanisms will then closely interplay to promote chronic joint inflammation in the several absence of appropriate treatment. This scenario, is shared with other autoimmune diseases where potentially pathogenic immune responses are present already before disease onset. Better understanding of these processes will allow both earlier diagnosis of RA and identification of those healthy individuals that are at risk of developing disease, opening possibilities for disease prevention. In this review, we discuss the iterative processes of innate and adaptive immunity responsible for the (longitudinal) development of immune reactions that may contribute to the development of RA.

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Authors: Catrina, A. I., Joshua, V., Klareskog, L., & Malmström, V.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Malmström, Vivianne
ORCID: Catrina, Anca I.
Joshua, Vijay
Klareskog, Lars
Malmström, Vivianne
Venue: Immunological Reviews
Publisher: Wiley
Published: 2015-12-19
Volume: 269
Issue: 1
Pages: 162-174
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/imr.12379
OpenAlex: W2211397752
Cited by: 160
References: 122
Citations by year: 2026: 9 · 2025: 7 · 2024: 10 · 2023: 15 · 2022: 13 · 2021: 15 · 2020: 20 · 2019: 17 · 2018: 16 · 2017: 22 · 2016: 15 · 2015: 1
FWCI: 2.80
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Immunological Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Knut and Alice Wallenberg foundation
Margareta af Ugglas foundation
Swedish Research Council
Swedish Cancer Society
IMI consortia BTCure (115142-2)
European Research Council (260167)
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: rheumatoid arthritis, autoimmunity, citrullinated proteins, post-translational protein modification, innate immunity, adaptive immunity, autoantigens, joint inflammation, disease onset, early diagnosis, disease prevention, genetic susceptibility
MeSH terms: Animals, Arthritis, Rheumatoid, Autoantigens, Citrulline, Humans, Immunity, Innate, Protein Processing, Post-Translational, Disease Progression, Genetic Predisposition to Disease, Adaptive Immunity

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