The ectonucleotidases CD 39 and CD 73: Novel checkpoint inhibitor targets

Cites (340)

Items 201–340 of 340

1. Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum
   Thomas C. Markello, Laura K. Pak, Cynthia St. Hilaire · 2011 · Molecular Genetics and Metabolism
2. Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer
   Paul M Hofman, Julien Cherfils‐Vicini, Marie Bazin, Marius Ilié, Thierry Juhel, Xavier Hébuterne, Éric Gilson, Annie Schmid‐Alliana, Olivier Boyer, Sahil Adriouch et al. · 2015 · Cancer Research
3. ATP-Induced Inflammation Drives Tissue-Resident Th17 Cells in Metabolically Unhealthy Obesity
   Julieta Pandolfi, Ariel Ferraro, Inés Sananez, Maria C. Gancedo, Plácida Baz, Luis Ariel Billordo, Leonardo Fainboim, Lourdes Arruvito · 2016 · The Journal of Immunology
4. Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action
   James C. Geoghegan, Gundo Diedrich, Xiaojun Lu, Kim Rosenthal, Kris F. Sachsenmeier, Herren Wu, William F. Dall’Acqua, Melissa M. Damschroder · 2016 · mAbs
5. Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model
   Claudia Sorrentino, Lucio Miele, Amalia Porta, Aldo Pinto, Silvana Morello · 2015 · Oncotarget
6. A Selective High-Affinity Antagonist of the P2Y14 Receptor Inhibits UDP-Glucose–Stimulated Chemotaxis of Human Neutrophils
   Matthew O. Barrett, Juliana I. Sesma, Christopher B. Ball · 2013 · Molecular Pharmacology
7. Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39
   Matthew Craig Hyman, Danica Petrovic‐Djergovic, Scott Visovatti et al. · 2009 · Journal of Clinical Investigation
8. Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7
   Andrea Vergani, Sara Tezza, Francesca D’Addio, Carmen Fotino, Kaifeng Liu, Monika A. Niewczas, Roberto Bassi, Ruth Damaris Molano, Sonja Kleffel, Alessandra Petrelli et al. · 2012 · Circulation
9. Extracellular adenosine regulates naive T cell development and peripheral maintenance
   Caglar Cekic, Duygu Sağ, Yuan‐Ji Day, Joel M Linden · 2013 · The Journal of Experimental Medicine
10. Expression of the P2X7 Receptor Increases the Ca2+ Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis
    Elena Adinolfi, Maria Giulia Callegari, Maria Cirillo, Paolo Pinton, Carlotta Giorgi, Dario Cavagna, Rosario Rizzuto, Francesco Di Virgilio · 2009 · Journal of Biological Chemistry
11. A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental Autoimmune Encephalomyelitis
    Jeffrey H. Mills, Do-Geun Kim, Antje Krenz, Jiang‐Fan Chen, Margaret S. Bynoe · 2012 · The Journal of Immunology
12. Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity.
    Jesus F. Salazar-Gonzalez, Dewey J. Moody, Janis V. Giorgi, O Martínez-Maza, Ronald T. Mitsuyasu, J L Fahey · 1985 · The Journal of Immunology
13. RNAi‐mediated CD73 suppression induces apoptosis and cell‐cycle arrest in human breast cancer cells
    Xiuling Zhi, Yingjian Wang, Xuerui Zhou, Jerry Yu, Rongrong Jian, Shaoxian Tang, Lianhua Yin, Ping Zhou · 2010 · Cancer Science
14. Adenosine suppresses activation of nuclear factor-κB selectively induced by tumor necrosis factor in different cell types
    Sekhar Majumdar, Bharat Bhushan Aggarwal · 2003 · Oncogene
15. Adora2b Adenosine Receptor Engagement Enhances Regulatory T Cell Abundance during Endotoxin-Induced Pulmonary Inflammation
    Heidi Ehrentraut, Joseph A. Westrich, Holger K. Eltzschig, Eric T. Clambey · 2012 · PLoS ONE
16. A3 AND P2Y2 RECEPTORS CONTROL THE RECRUITMENT OF NEUTROPHILS TO THE LUNGS IN A MOUSE MODEL OF SEPSIS
    Yoshiaki Inoue, Yu Chen, Mark Hirsh, Linda Yip, Wolfgang Georg JUNGER · 2008 · Shock
17. Modulation of endothelial cell migration by extracellular nucleotides
    Laurie Erb, Katarzyna Koziak, Robert Jarzyna, Marcia R. Wink, Olaf Guckelberger, Jan Krzysztof Blusztajn, Vickery Trinkaus‐Randall, Gary A. Weisman, Simon Christopher Robson, Elżbieta Kaczmarek · 2005 · Thrombosis and Haemostasis
18. Disordered Purinergic Signaling Inhibits Pathological Angiogenesis in Cd39/Entpd1-Null Mice
    Shaun W. Jackson, Tomokazu Hoshi, Yan Wu · 2007 · American Journal Of Pathology
19. Cultured human follicular dendritic cells. Growth characteristics and interactions with B lymphocytes
    Edward A. Clark, Kenneth H. Grabstein, G L Shu · 1992 · The Journal of Immunology
20. Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells
    Frédéric Marteau, Nathalie Suarez Gonzalez, David Communi, Michel Goldman, Jean‐Marie Boeynaems, Didier Communi · 2005 · Blood
21. The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification
    Francis J. Coffey, Sang-Yun Lee, Terkild B. Buus, Jens-Peter Holst Lauritsen, Gladys W. Wong, Michelle L. Joachims, Linda F. Thompson, Juan Carlos Zúñiga‐Pflücker, Dietmar J. Kappes, David L. Wiest · 2014 · The Journal of Experimental Medicine
22. The A2B Adenosine Receptor Promotes Th17 Differentiation via Stimulation of Dendritic Cell IL-6
    Jeffrey M. Wilson, Courtney C. Kurtz, Steven G. Black, William G. Ross, Mohammed S Alam, Joel M Linden, Peter B. Ernst · 2011 · The Journal of Immunology
23. Tasquinimod Modulates Suppressive Myeloid Cells and Enhances Cancer Immunotherapies in Murine Models
    Li Shen, Anette Sundstedt, Michael J. Ciesielski, Kiersten Marie Miles, Mona Celander, Remi M. Adelaiye-Ogala, Ashley R. Orillion, Eric Stefano Ciamporcero, Swathi Ramakrishnan, Leigh Ellis et al. · 2014 · Cancer Immunology Research
24. Dependence of Immunoglobulin Class Switch Recombination in B Cells on Vesicular Release of ATP and CD73 Ectonucleotidase Activity
    Francesca Schena, Stefano Volpi, Caterina Elisa Faliti, Federica Penco, Spartaco Santi, Michele Proietti, Ursula Schenk, Gianluca Damonte, Annalisa Salis, Marta Bellotti et al. · 2013 · Cell Reports
25. Palmitoylation Targets CD39/Endothelial ATP Diphosphohydrolase to Caveolae
    Katarzyna Koziak, Elżbieta Kaczmarek, Ágnes Kittel et al. · 2000 · Journal of Biological Chemistry
26. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression
    Jessica L. Bowser, Michael R. Blackburn, Gregory L. Shipley, Jose G. Molina, Kenneth Dunner, Russell R. Broaddus · 2015 · Journal of Clinical Investigation
27. Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment
    Christoph Bergmann, Laura Strauss, Reinhard Zeidler · 2007 · Cancer Immunology Immunotherapy
28. CD73-Generated Adenosine Restricts Lymphocyte Migration into Draining Lymph Nodes
    Masahide Takedachi, Dongfeng Qu, Yukihiko Ebisuno et al. · 2008 · The Journal of Immunology
29. CD73 Expression as a Potential Marker of Good Prognosis in Breast Carcinoma
    Anna Maria Supernat, Aleksandra Markiewicz, Marzena Wełnicka-Jaśkiewicz, Barbara Seroczyńska, Jarosław Skokowski, Aleksandra Sejda, Jolanta Szade, Piotr Czapiewski, Wojciech Biernat, Anna Joanna Zaczek · 2011 · Applied immunohistochemistry & molecular morphology
30. Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A–induced hepatitis
    Guido Beldi, Yan Wu, Yara Banz, Michael A. Nowak, Lindsay Miller, Keiichi Enjyoji, Arvand Haschemi, Gennady G. Yegutkin, Daniel Candinas, Mark Adrian Exley et al. · 2008 · Hepatology
31. Cholesterol-dependent Lipid Assemblies Regulate the Activity of the Ecto-nucleotidase CD39
    Agathi Papanikolaou, Alexandra Papafotika, Carol Murphy, Thomais Papamarcaki, Orestes Tsolas, Marek Dráb, Teymuras V. Kurzchalia, Michael E. Kasper, Savvas Christoforidis · 2005 · Journal of Biological Chemistry
32. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier
    Do-Geun Kim, Margaret S. Bynoe · 2016 · Journal of Clinical Investigation
33. Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer in Cd39/Entpd1 null Mice
    Xiaofeng Sun, Lihui Han, Pankaj Seth, Bian Shu, Linglin Li, Eva Csizmadia, Wolfgang Georg JUNGER, Moritz Schmelzle, Anny Usheva, Elliot B. Tapper et al. · 2012 · Hepatology
34. An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering
    Elizabeth Ntantie, Patrick Gonyo, Ellen Lorimer, Andrew D. Hauser, Nathan J. Schuld, Donna M. McAllister, Balaraman Kalyanaraman, Michael B. Dwinell, John A. Auchampach, Carol L. Williams · 2013 · Science Signaling
35. Dual, enzymatic and non-enzymatic, function of ecto-5'-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells.
    Rafał Sądej, Andrzej C. Składanowski · 2012 · Acta Biochimica Polonica
36. Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma
    Giovanni Forte, Rosalinda Sorrentino, Antonella Montinaro, Antonio Luciano, Ian Michael Adcock, Piera Maiolino, Claudio Arra, Carla Cicala, Aldo Pinto, Silvana Morello · 2012 · The Journal of Immunology
37. Hypoxia-Driven Adenosine Accumulation: A Crucial Microenvironmental Factor Promoting Tumor Progression
    Peter W. Vaupel, Arnulf Mayer · 2016 · Advances in experimental medicine and biology
38. Adenosine inhibits the adhesion of anti-CD3-activated killer lymphocytes to adenocarcinoma cells through an A3 receptor.
    Willena M. MacKenzie, David W. Hoskin, Jonathan Blay · 1994 · PubMed
39. CD73 Engagement Promotes Lymphocyte Binding to Endothelial Cells Via a Lymphocyte Function-Associated Antigen-1-Dependent Mechanism
    Laura M. Airas, Jussi Niemelä, Sirpa Jalkanen · 2000 · The Journal of Immunology
40. NADH oxidase-dependent CD39 expression by CD8+ T cells modulates interferon gamma responses via generation of adenosine
    Aiping Bai, Alan C. Moss, Sonja Rothweiler, Maria Serena Longhi, Yan Wu, Wolfgang Georg JUNGER, Simon Christopher Robson · 2015 · Nature Communications
41. Crystal Structure of a Soluble Form of Human CD73 with Ecto‐5′‐Nucleotidase Activity
    Dominic P. H. M. Heuts, Martin J. Weissenborn, Rouslan V. Olkhov, Andrew M. Shaw, Jennet Gummadova, Colin Levy, Nigel Shaun Scrutton · 2012 · ChemBioChem
42. 内皮細胞表面F1‐F0ATPシンターゼはATP合成に働き、アンギオスタチンにより阻害される
    Tammy L. Moser, D Kenan, T A Ashley, Roy J A, Goodman M D, U K Misra, D J Cheek, S Pizzo · 2001
43. Involvement of multiple P2Y receptors and signaling pathways in the action of adenine nucleotides diphosphates on human monocyte-derived dendritic cells
    Frédéric Marteau, Didier Communi, Jean‐Marie Boeynaems, Nathalie Suarez Gonzalez · 2004 · Journal of Leukocyte Biology
44. Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness
    Shannon P. Hilchey, James J. Kobie, Mathew R. Cochran, Shelley Secor‐Socha, Jyh-Chiang E. Wang, Ollivier Hyrien, Richard Burack, Tim R. Mosmann, Sally A. Quataert, Steven H. Bernstein · 2009 · The Journal of Immunology
45. Isolated CD39 Expression on CD4+ T Cells Denotes both Regulatory and Memory Populations
    Qiang Zhou, Jun Yan, Prabhakar Putheti, Yan Wu, X. Sun, Vasilis Toxavidis, John Tigges, Nasim Kassam, Keiichi Enjyoji, Simon Christopher Robson et al. · 2009 · American Journal of Transplantation
46. Extracellular adenosine signaling induces CX3CL1 expression in the brain to promote experimental autoimmune encephalomyelitis
    Jeffrey H. Mills, Leah M. Alabanza, Deeqa Mahamed, Margaret S. Bynoe · 2012 · Journal of Neuroinflammation
47. P2Y6 Receptor Potentiates Pro-Inflammatory Responses in Macrophages and Exhibits Differential Roles in Atherosclerotic Lesion Development
    Ricardo Alexandrino Garcia, Mujing Yan, Debra J. Search, Rongan Zhang, Nancy L. Carson, Carol S. Ryan, Constance Smith-Monroy, Joanna J. Zheng, Jian Chen, Yan Kong et al. · 2014 · PLoS ONE
48. Deletion of Cd39 on Natural Killer Cells Attenuates Hepatic Ischemia/Reperfusion Injury in Mice
    Guido Beldi, Yara Banz, Alexander Kroemer, Xiaofeng Sun, Yan Wu, Nadine Graubardt, Alyssa Rellstab, Martina Nowak, Keiichi Enjyoji, X.C. Li et al. · 2009 · Hepatology
49. Wnt and β-catenin signaling target the expression of ecto-5′-nucleotidase and increase extracellular adenosine generation
    Józef Spychała, Jan Kitajewski · 2004 · Experimental Cell Research
50. CD39 Expression on T Lymphocytes Correlates With Severity of Disease in Patients With Chronic Lymphocytic Leukemia
    Dianne D. Pulte, Richard R. Furman, Marinus Johan Broekman, Joan H.F. Drosopoulos, Harold S. Ballard, Kim E. Olson, Jorge R. Kizer, Aaron J. Marcus · 2011 · Clinical Lymphoma Myeloma & Leukemia
51. Characterization of Human CD39+ Th17 Cells with Suppressor Activity and Modulation in Inflammatory Bowel Disease
    Maria Serena Longhi, Alan C. Moss, Aiping Bai, Yan Wu, Huang Huang, Adam S. Cheifetz, Francisco Javier Quintana, Simon Christopher Robson · 2014 · PLoS ONE
52. Ecto-5′-nucleotidase (CD73) promotes tumor angiogenesis
    Li Wang, Shaoxian Tang, Yingjian Wang, Siguang Xu, Jerry Yu, Xiuling Zhi, Zhouluo Ou, Jiayin Yang, Ping Zhou, Zhimin Shao · 2013 · Clinical & Experimental Metastasis
53. Effects of ecto-5'-nucleotidase on human breast cancer cell growth in vitro and in vivo
    Xuerui Zhou, Xiuling Zhi, Ping Zhou, SF Chen, Fengdi Zhao, Zhimin Shao, Zhouluo Ou, Lianhua Yin · 2007 · Oncology Reports
54. P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment
    Young Nak Joo, Hana Jin, So Young Eun, Sang Won Park, Ki Churl Chang, Hye Jung Kim · 2014 · Oncotarget
55. Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes
    Brian Paul Chadwick, Anna-Maria Frischauf · 1997 · Mammalian Genome
56. Purine and pyrimidine nucleotides potentiate activation of NADPH oxidase and degranulation by chemotactic peptides and induce aggregation of human neutrophils via G proteins
    Roland Seifert, Katharina Wenzel, Fritz Eckstein · 1989 · European Journal of Biochemistry
57. Extracellular Adenosine Production by ecto-5′-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis
    Florian Wirsdörfer, Simone de Leve, Federica Cappuccini, Therese Eldh, Alina Viktorovna Meyer, Eva Gau, Linda F. Thompson, Ning‐Yuan Chen, Harry Karmouty‐Quintana, Ute Fischer et al. · 2016 · Cancer Research
58. CD39: Interface Between Vascular Thrombosis and Inflammation
    Yogendra M. Kanthi, Nadia R. Sutton, David J. Pinsky · 2014 · Current Atherosclerosis Reports
59. CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+T effector cells in patients with head and neck squamous cell carcinoma
    Magis Mandapathil, Mirosław J. Szczepański, Malgorzata Harasymczuk, Jin Ren, Dongmei Cheng, Edwin Kerry Jackson, Elieser Gorelik, Jonas Talmadge Johnson, Stephan Lang, Theresa L. Whiteside · 2012 · OncoImmunology
60. Extracellular adenosine metabolism in immune cells in melanoma
    Viktor Umansky, Ivan Shevchenko, Alexandr V. Bazhin, Jochen Sven Utikal · 2014 · Cancer Immunology Immunotherapy
61. CD 73 is a phenotypic marker of effector memory T h17 cells in inflammatory bowel disease
    Glen A. Doherty, Aiping Bai, Dusan Hanidziar, Maria Serena Longhi, Garrett O. Lawlor, Prabhakar Putheti, Eva Csizmadia, Martina Nowak, Adam S. Cheifetz, Alan C. Moss et al. · 2012 · European Journal of Immunology
62. Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration
    Filip Kukulski, Fethia Ben Yebdri, Joanna Lecka, Gilles Kauffenstein, Sébastien A. Lévesque, Mireia Martı́n-Satué, Jean Sévigny · 2009 · Cytokine
63. Different role of CD73 in leukocyte trafficking via blood and lymph vessels
    Annika Ålgars, Marika Karikoski, Gennady G. Yegutkin, Patrizia Stoitzner, Jussi Niemelä, Marko Salmi, Sirpa Jalkanen · 2011 · Blood
64. Decreased frequency of CD73+CD8+ T cells of HIV-infected patients correlates with immune activation and T cell exhaustion
    Ilona Tóth, Anh Q. Le, Philip Hartjen, Adriana Thomssen, Verena Matzat, Clara Lehmann, Christoph Scheurich, Claudia Beisel, Philipp Busch, Olaf Degen et al. · 2013 · Journal of Leukocyte Biology
65. Adherent Leukocytes Prevent Adenosine Formation and Impair Endothelial Barrier Function by Ecto-5′-nucleotidase/CD73-dependent Mechanism
    Tiina A Henttinen, Sirpa Jalkanen, Gennady G. Yegutkin · 2003 · Journal of Biological Chemistry
66. Natural killer cells acquire CD73 expression upon exposure to mesenchymal stem cells
    Debanjana Chatterjee, Dejene Milkessa Tufa, Heike Baehre · 2014 · Blood
67. Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells
    Chiuhui Mary Wang, Cristina Ploia, Fabio Anselmi, Adélaïda Sarukhan, Antonella Viola · 2014 · The EMBO Journal
68. Peptidoglycan derived fromStaphylococcus epidermidisinduces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells
    Jennifer Robertson, Sue Lang, Peter A. Lambert, Patricia E. Martin · 2010 · Biochemical Journal
69. Improving cancer immunotherapy by targeting the STATe of MDSCs
    Nienke de Haas, Coco C. H. de Koning, Lisanne M. Spilgies, I. Jolanda M. de Vries, Stanleyson V. Hato · 2016 · OncoImmunology
70. ATP secreted by endothelial cells blocks CX3CL1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y11 receptor activation
    Stefania Gorini, Giulia Callegari, Giulia Romagnoli, Caterina Mammi, Domenico Mavilio, Giuseppe M.C. Rosano, Massimo Fini, Francesco Di Virgilio, Sara Gulinelli, Simonetta Falzoni et al. · 2010 · Blood
71. Heightened expression of CD39 by regulatory T lymphocytes is associated with therapeutic remission in inflammatory bowel disease
    Gibson, David J., Elliott, Louise, McDermott, Edel, Tosetto, Miriam, Keegan, Denise, Byrne, Kathryn, Martin, Sean T., Rispens, Theo, Cullen, Garret, Mulcahy, Hugh E. et al. · 2015 · Inflammatory Bowel Diseases
72. Simvastatin inhibits the pro-inflammatory and pro-thrombotic effects of IL-17 and TNF-α on endothelial cells
    A. Hot, Fabien Lavocat, Vanina Lenief, Pierre Miossec · 2012 · Annals of the Rheumatic Diseases
73. The role of glycosyl phosphatidyl inositol (GPI)-anchored cell surface proteins in T-cell activation
    Rolf Loertscher, Paula Lavery · 2002 · Transplant Immunology
74. Reducing CD73 Expression by IL1β-Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors
    Shilpak Chatterjee, Krishnamurthy Thyagarajan, Pravin Kesarwani, Jin Hyang Song, Myroslawa Soloshchenko, Jianing Fu, Stefanie R. Bailey, Chenthamarakshan Vasu, Andrew S. Kraft, Chrystal Mary Paulos et al. · 2014 · Cancer Research
75. Human ectonucleotidase-expressing CD25 high Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions
    Marion Thibaudin, Marie Chaix, Romain Boidot, Frédérique Végran, Valentin Dérangère, Emeric Limagne, Hélène Berger, Sylvain Ladoire, Lionel Apétoh, François Ghiringhelli · 2015 · OncoImmunology
76. CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence
    Laura J. Conter, Eunice Song, Mark Jay Shlomchik, Mary M. Tomayko · 2014 · PLoS ONE
77. CD73 mediates adhesion of B cells to follicular dendritic cells
    Laura M. Airas, Sirpa Jalkanen · 1996 · Blood
78. NAADP+ is an agonist of the human P2Y11 purinergic receptor
    Iliana Moreschi, Santina Bruzzone, Nicoletta Bodrato · 2007 · Cell Calcium
79. Regulatory T Cell–Derived Adenosine Induces Dendritic Cell Migration through the Epac-Rap1 Pathway
    Sabine Ring, Anna A. Pushkarevskaya, Hansjörg Schild · 2015 · The Journal of Immunology
80. Flow-dependent expression of ectonucleotide tri(di)phosphohydrolase-1 and suppression of atherosclerosis
    Yogendra M. Kanthi, Matthew Craig Hyman, Hui Liao, Amy E. Baek, Scott Visovatti, Nadia R. Sutton, Sascha N. Goonewardena, Mithun K. Neral, Hanjoong Jo, David J. Pinsky · 2015 · Journal of Clinical Investigation
81. Early Prediction of Persistent Organ Failure by Soluble CD73 in Patients With Acute Pancreatitis*
    Mikael Maksimow, Lea Kyhälä, Anne Nieminen, Leena Kylänpää, Kristiina Aalto, Kati Elima, Panu Juhani Mentula, Mari S. Lehti, Pauli Antero Puolakkainen, Gennady G. Yegutkin et al. · 2014 · Critical Care Medicine
82. Juxta-articular joint-capsule mineralization in CD73 deficient mice: Similarities to patients with NT5E mutations
    Qiaoli Li, Thea P. Price, John P. Sundberg · 2014 · Cell Cycle
83. Combining phenotypic and proteomic approaches to identify membrane targets in a ‘triple negative’ breast cancer cell type
    Steven J. Rust, Sandrine Guillard, Kris F. Sachsenmeier, Carl M. Hay, Max Davidson, Anders Karlsson, Roger Karlsson, Erin Brand, David Lowne, John G. Elvin et al. · 2013 · Molecular Cancer
84. CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease
    Rodrigo Liberal, Charlotte R. Grant, Yun Ma, Eva Csizmadia, Zhenghui Gordon Jiang, Michael A. Heneghan, Eric U. Yee, Giorgina Mieli‐Vergani, Diego Vergani, Simon Christopher Robson et al. · 2016 · Journal of Autoimmunity
85. Transmembrane Domains Confer Different Substrate Specificities and Adenosine Diphosphate Hydrolysis Mechanisms on CD39, CD39L1, and Chimeras
    Alison Grinthal, Guido Guidotti · 2002 · Biochemistry
86. CD39 as a Caveolar-Associated Ectonucleotidase
    Ágnes Kittel, Elżbieta Kaczmarek, Jean Sévigny, K. Lengyel, Eva Csizmadia, Simon Christopher Robson · 1999 · Biochemical and Biophysical Research Communications
87. Increased CD39 expression on CD4+ T lymphocytes has clinical and prognostic significance in chronic lymphocytic leukemia
    Chava Perry, Inbal Hazan‐Halevy, Sigi Kay, Michal Cipok, Dan Grisaru, Varda R. Deutsch, Aaron Polliack, Elizabeth Naparstek, Yair Herishanu · 2012 · Annals of Hematology
88. Mammalian Plasma Membrane Ecto-nucleoside Triphosphate Diphosphohydrolase 1, CD39, Is Not Active Intracellularly
    Xiaotian Zhong, Rajeev Kumar Malhotra, Rachel V. Woodruff · 2001 · Journal of Biological Chemistry
89. CD39, NTPDase 1, is attached to the plasma membrane by two transmembrane domains. Why?
    Alison Grinthal, Guido Guidotti · 2006 · Purinergic Signalling
90. Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer
    Bertrand Allard, Martin Turcotte, John Stagg · 2014 · Expert Opinion on Therapeutic Targets
91. Purine catabolism in polymorphonuclear neutrophils. Phorbol myristate acetate-induced accumulation of adenosine owing to inactivation of extracellularly released adenosine deaminase.
    Geert van Waeg, Greet Van den Berghe · 1991 · Journal of Clinical Investigation
92. IL-7 Modulates In Vitro and In Vivo Human Memory T Regulatory Cell Functions through the CD39/ATP Axis
    Mehwish Younas, Sophie Hüe, Christine Lacabaratz, Aurélie Guguin, Aurélie Wiedemann, Mathieu Surénaud, Stéphanie Beq, Thérèse Croughs, Jean‐Daniel Lelièvre, Yves Lévy · 2013 · The Journal of Immunology
93. The structure of the nucleoside triphosphate diphosphohydrolases (NTPDases) as revealed by mutagenic and computational modeling analyses
    Terence L. Kirley, Patrick A. Crawford, Thomas M. Smith · 2006 · Purinergic Signalling
94. Regulation of peripheral T cell activation by calreticulin
    Simona Porcellini, Elisabetta Traggiai, Ursula Schenk, Denise Ferrera, Michela Matteoli, Antonio Lanzavecchia, Marek Michalak, Fabio Grassi · 2006 · The Journal of Experimental Medicine
95. IL‐12 and IL‐4 activate a CD39‐dependent intrinsic peripheral tolerance mechanism in CD8+ T cells
    Alistair Noble, Hema Mehta, Andrew Lovell · 2016 · European Journal of Immunology
96. Hypoxia/Reoxygenation Inhibits P2Y11 Receptor Expression and Its Immunosuppressive Activity in Human Dendritic Cells
    Stéphanie Chadet, Fabrice Ivanés, Lauriane Benoist, Charlotte Salmon Gandonnière, Roseline Guibon, Florence Velge-Roussel, Dominique Babuty, Christophe Baron, Sébastien Roger, Denis Angoulvant · 2015 · The Journal of Immunology
97. Identification and characterization of latency-associated peptide-expressing γδ T cells
    Rafael Machado Rezende, Andre Pires da Cunha, Chantal Kuhn, Stephen J. Rubino, Hanane M’Hamdi, Galina Gabriely, Tyler Vandeventer, Shirong Liu, Ron Cialic, Natália Pinheiro-Rosa et al. · 2015 · Nature Communications
98. Purinergic Signaling to Terminate TLR Responses in Macrophages
    Kajal Hamidzadeh, David M. Mosser · 2016 · Frontiers in Immunology
99. CD73 Plays a Protective Role in Collagen-Induced Arthritis
    Pavel Chrobák, Roxanne Charlebois, Pavel Rejtar, Rana El Bikai, Bertrand Allard, John Stagg · 2015 · The Journal of Immunology
100. Purinergic Signaling as a Regulator of Th17 Cell Plasticity
     Dominique Fernández, Felipe Flores‐Santibáñez, Jocelyn Neira, Francisco Osorio‐Barrios, Gabriela Tejón, Sarah Núñez, Yessia Hidalgo, Maria Jose Fuenzalida, Daniel Meza, Gonzalo Ureta et al. · 2016 · PLoS ONE
101. High expression of CD39/ENTPD1 in malignant epithelial cells of human rectal adenocarcinoma
     Bin Zhang, Bo Cheng, Fengsheng Li · 2015 · Tumor Biology
102. CD73 Activity is Dispensable for the Polarization of M2 Macrophages
     Dominik Eichin, Juha P. Laurila, Sirpa Jalkanen, Marko Salmi · 2015 · PLoS ONE
103. Oxidized ATP inhibits T‐cell‐mediated autoimmunity
     Philipp Alexander Lang, Doron Merkler, Pauline Funkner et al. · 2010 · European Journal of Immunology
104. Purinergic P2X7 Receptor Drives T Cell Lineage Choice and Shapes Peripheral γδ Cells
     Michela Frascoli, Jessica Marcandalli, Ursula Schenk, Fabio Grassi · 2012 · The Journal of Immunology
105. Pulmonary Natural Killer T Cells Play an Essential Role in Mediating Hyperoxic Acute Lung Injury
     Martina Nowak-Machen, Moritz Schmelzle, Dusan Hanidziar et al. · 2013 · American Journal of Respiratory Cell and Molecular Biology
106. Expression of P2X5 in lymphoid malignancies results in LRH‐1‐specific cytotoxic T‐cell‐mediated lysis
     Ingrid M. Overes, B. de Rijke, Agnes van Horssen-Zoetbrood et al. · 2008 · British Journal of Haematology
107. CD73 Expressed on γδ T Cells Shapes Their Regulatory Effect in Experimental Autoimmune Uveitis
     Dongchun Liang, Aijun Zuo, Ronglan Zhao, Hui Shao, Willi K. Born, Rebecca L. O’Brien, Henry J. Kaplan, Deming Sun · 2016 · PLoS ONE
108. CD39: A new surface marker of mouse regulatory γδ T cells
     Atsushi Otsuka, Sho Hanakawa, Yoshiki Miyachi, Kenji Kabashima · 2013 · Journal of Allergy and Clinical Immunology
109. Tenascin C interacts with Ecto-5′-nucleotidase (eN) and regulates adenosine generation in cancer cells
     Rafał Sądej, Kunihiro Inai, Zenon Rajfur · 2007 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
110. Rheumatoid Factor B Cell Memory Leads to Rapid, Switched Antibody-Forming Cell Responses
     Rebecca A. Sweet, Jaime L. Cullen, Mark Jay Shlomchik · 2013 · The Journal of Immunology
111. Blockade of murine T cell activation by antagonists of P2Y6 and P2X7 receptors
     Mitsutoshi Tsukimoto, Akihiro Tokunaga, Hitoshi Harada, Shuji Kojima · 2009 · Biochemical and Biophysical Research Communications
112. CD73 Inhibition Shifts Cardiac Macrophage Polarization toward a Microbicidal Phenotype and Ameliorates the Outcome of Experimental Chagas Cardiomyopathy
     N. Ponce, L. Sanmarco, N. Eberhardt, Mónica C García, H. W. Rivarola, R. Cano, M. Aoki · 2016 · Journal of Immunology
113. Ecto‐5′‐nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature
     Gennady G. Yegutkin, Kaisa Auvinen, Pia Rantakari · 2014 · European Journal of Immunology
114. Activation of B lymphocyte maturation by a human follicular dendritic cell line, FDC-1
     Edward A. Clark, Kenneth H. Grabstein, Allen M. Gown · 1995 · The Journal of Immunology
115. E-NTPDases in human airways: Regulation and relevance for chronic lung diseases
     Lauranell H. Burch, Maryse Picher · 2006 · Purinergic Signalling
116. Intestinal immunopathology is associated with decreased CD73-generated adenosine during lethal infection
     V Francois, Hussein Shehade, Valérie Acolty, Nicolas Preyat, P. Delrée, Muriel Moser, Guillaume Oldenhove · 2014 · Mucosal Immunology
117. CD 73‐mediated adenosine production promotes stem cell‐like properties in mouse Tc17 cells
     Felipe Flores‐Santibáñez, Dominique Fernández, Daniel Meza, Gabriela Tejón, Leonardo Vargas, Lorena Varela‐Nallar, Sebastián B. Arredondo, Victoria Guixé, Mario S. Rosemblatt, Marı́a Rosa Bono et al. · 2015 · Immunology
118. Calcification of joints and arteries: second report with novel NT5E mutations and expansion of the phenotype
     Zeng Zhang, Zeng Zhang, Jin-Wei He · 2015 · Journal of Human Genetics
119. Roles of the Adenosine Receptor and CD73 in the Regulatory Effect of γδ T Cells
     Dongchun Liang, Aijun Zuo, Hui Shao, Mingjiazi Chen, Henry J. Kaplan, Deming Sun · 2014 · PLoS ONE
120. The CD39 molecule defines distinct cytotoxic subsets within alloactivated human CD8‐positive cells
     Cécile Gouttefangeas, Indra Gusti Mansur, Michel Schmid · 1992 · European Journal of Immunology
121. Attenuation of ecto-5'-nucleotidase activity and adenosine release in activated human polymorphonuclear leukocytes.
     Masafumi Kitakaze, M Hori, 敏一 森岡 · 1993 · Circulation Research
122. Biochemical and mass spectrometric characterization of soluble ecto-5'-nucleotidase from bull seminal plasma
     Carlo Fini, Fabio Talamo, Silvia CHERRI · 2003 · Biochemical Journal
123. The inhibitory effects of extracellular ATP on the growth of nasopharyngeal carcinoma cells via P2Y2 receptor and osteopontin
     Guang Yang, Shenghong Zhang, Yanling Zhang · 2014 · Journal of Experimental & Clinical Cancer Research
124. Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens
     Georg Gruenbacher, Hubert Gander, Andrea Rahm, Marco Idzko, Oliver Nussbaumer, Martin Thurnher · 2016 · Cell Reports
125. Purinergic Signalling and Endothelium
     Geoffrey Burnstock · 2016 · Current Vascular Pharmacology
126. Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17
     Christopher C. Paustian, Patricia Taylor, Terrence D. Johnson, Min Xu, Nancy Ramirez, Kenneth S. Rosenthal, Suyu Shu, Peter A. Cohen, Brian J. Czerniecki, Gary K. Koski · 2013 · PLoS ONE
127. Identification of a novel human memory T-cell population with the characteristics of stem-like chemo-resistance
     Kenji Murata, Tomohide Tsukahara, Makoto Emori, Yuji Shibayama, Emi Mizushima, Hiroshi Matsumiya, Keiji Yamashita, Mitsunori Kaya, Yoshihiko Hirohashi, Takayuki Kanaseki et al. · 2016 · OncoImmunology
128. CD73 and Adhesion of B-Cells to Follicular Dendritic Cells
     Laura M. Airas · 1998 · Leukemia & lymphoma/Leukemia and lymphoma
129. Induction of murine adenosine A2A receptor expression by LPS: analysis of the 5′ upstream promoter
     Genie Elson, M Eisenberg, Charu Garg, Shalini Persaud Outram, Christopher Ferrante, György Haskó, S. Joseph Leibovich · 2013 · Genes and Immunity
130. 1α,25‐dihydroxyvitamin D3 acts via transforming growth factor‐β to up‐regulate expression of immunosuppressive CD73 on human CD4+ Foxp3– T cells
     Elizabeth H. Mann, Emma S. Chambers, Yin‐Huai Chen, David F. Richards, Catherine M. Hawrylowicz · 2015 · Immunology
131. γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes
     Hideyuki Ujiie, Ethan M. Shevach · 2016 · The Journal of Immunology
132. Altered phenotype of regulatory T cells associated with lack of human immunodeficiency virus (HIV)-1-specific suppressive function
     Catherine Burton, Samantha J. Westrop, Ijeoma G. Eccles-James, Adriano Boasso, M.R. Nelson, Mark Bower, Nesrina Imami · 2011 · Clinical & Experimental Immunology
133. Antisense to Epstein Barr Virus-encoded LMP1 does not affect the transcription of viral and cellular proliferation-related genes, but induces phenotypic effects on EBV-transformed B lymphocytes
     Silvia Masciarelli, Benedetta Mattioli, Roberta Galletti · 2002 · Oncogene
134. Adenosine regulates radiation therapy-induced anti-tumor immunity
     Erik Wennerberg, Noriko Kawashima, Sandra Demaria · 2015 · Journal for ImmunoTherapy of Cancer
135. Human Placental Ecto-5′-nucleotidase: Isoforms and Chemical Crosslinking Products of the Membrane-Bound and Isolated Enzyme
     S Buschette-Brambrink, Wolf Gutensohn · 1989 · Biological Chemistry Hoppe-Seyler
136. Abstract 1476: A therapeutic antibody that inhibits CD73 activity by dual mechanisms
     Bryan C. Barnhart, Emanuela I. Sega, Aaron P. Yamniuk et al. · 2016 · Cancer Research
137. Abstract 1538: Levels and enzyme activity of CD73 in primary samples from cancer patients
     Qihui Huang, Nicholas M. Durham, Erin Sult et al. · 2015 · Cancer Research
138. Abstract 3361: CD73 expression on tumor-infiltrating breast cancer leukocytes
     Laurence Buisseret, Soizic Garaud, Bertrand Allard · 2015 · Cancer Research
139. Abstract 2344: Discovery and characterization of new original blocking antibodies targeting the CD73 immune checkpoint for cancer immunotherapy
     Marc Giraudon Paoli, Séverine Augier, Marilyne Royannez Blemont et al. · 2016 · Cancer Research
140. Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3)
     2002