COVID‐19 severity from Omicron and Delta SARS‐CoV‐2 variants
Open accessAbstract
The Omicron variant of SARS‐CoV‐2 achieved worldwide dominance in late 2021. Early work suggests that infections caused by the Omicron variant may be less severe than those caused by the Delta variant. We sought to compare clinical outcomes of infections caused by these two strains, confirmed by whole genome sequencing, over a short period of time, from respiratory samples collected from SARS‐CoV‐2 positive patients at a large medical center. We found that infections caused by the Omicron variant caused significantly less morbidity, including admission to the hospital and requirement for oxygen supplementation, and significantly less mortality than those caused by the Delta variant.
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The Delta variant was characterized by higher transmissibility and severity compared to previously circulating SARS-CoV-2 strains.
“The Delta variant was characterized by its higher transmissibility and severity compared to the previously circulating strains [15,16]”
From Vaccine effectiveness and duration of protection of COVID-19 mRNA vaccines against Delta and Omicron BA.1 symptomatic and severe COVID-19 outcomes in adults aged 50 years and over in France (2023) · cites this paper as [16]
The Results and Discussion report greater clinical severity with Delta than with Omicron. But Omicron is not a previously circulating strain relative to Delta, and the paper does not assess Delta’s transmissibility or compare its severity with earlier strains. (LLM, conf=0.84)
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- Authors
- Wrenn, J. O., Pakala, S. B., Vestal, G., Shilts, M. H., Brown, H. M., Bowen, S. M., Strickland, B. A., Williams, T., Mallal, S. A., Jones, I. D., Schmitz, J. E., Self, W. H., & Das, S. R.
- Affiliations
- Vanderbilt University Medical Center (US)
- Corresponding author
- Das, Suman R.
- ORCID
- Venue
- Influenza and Other Respiratory Viruses
- Publisher
- Wiley
- Published
- 2022-04-13
- Volume
- 16
- Issue
- 5
- Pages
- 832-836
- ISSN
- 1750-2640 (ISSN-L)
- 1750-2659
- PMC
- PMC9111734
- OpenAlex
- W4223505801
- Cited by
- 99
- References
- 13
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 20 · 2023: 39 · 2022: 22
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Influenza and Other Respiratory Viruses (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R21AI142321‐02S1, R21AI149262, R21AI154016, R21AI142321)
- National Institutes of Health (G20RR030956, P30EY08126, P30CA68485, UL1RR024975)
- National Heart, Lung, and Blood Institute (R01HL146401, K23HL148638)
- Centers for Disease Control and Prevention (75D3012110094)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Keywords
- COVID-19 pandemic, Omicron variant, Delta variant, SARS-CoV-2, disease severity, clinical outcomes, hospitalization, supplemental oxygen, mortality, variant comparison
- MeSH terms
- COVID-19, SARS-CoV-2, Humans
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