Cited by 99SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 epidemiological studies

COVID‐19 severity from Omicron and Delta SARS‐CoV‐2 variants

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Wrenn, Jesse O., Pakala, Suman B., Vestal, Grant, Shilts, Meghan H., Brown, Hunter M., Bowen, Sara M., Strickland, Britton A., Williams, Timothy +5 more·2022·Influenza and Other Respiratory Viruses

Abstract

The Omicron variant of SARS‐CoV‐2 achieved worldwide dominance in late 2021. Early work suggests that infections caused by the Omicron variant may be less severe than those caused by the Delta variant. We sought to compare clinical outcomes of infections caused by these two strains, confirmed by whole genome sequencing, over a short period of time, from respiratory samples collected from SARS‐CoV‐2 positive patients at a large medical center. We found that infections caused by the Omicron variant caused significantly less morbidity, including admission to the hospital and requirement for oxygen supplementation, and significantly less mortality than those caused by the Delta variant.

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Research works printed but not linked: 1

  1. Lewnard JA, Hong VX, Patel MM, Kahn R, Lipsitch M, Tartof SY. Clinical outcomes among patients infected with Omicron (B. 1.1. 529) SARS-CoV-2 variant in southern California. medRxiv. 2022.

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Authors
Wrenn, J. O., Pakala, S. B., Vestal, G., Shilts, M. H., Brown, H. M., Bowen, S. M., Strickland, B. A., Williams, T., Mallal, S. A., Jones, I. D., Schmitz, J. E., Self, W. H., & Das, S. R.
Affiliations
Vanderbilt University Medical Center (US)
Corresponding author
Das, Suman R.
Venue
Influenza and Other Respiratory Viruses
Publisher
Wiley
Published
2022-04-13
Volume
16
Issue
5
Pages
832-836
ISSN
  • 1750-2640 (ISSN-L)
  • 1750-2659
OpenAlex
W4223505801
Cited by
99
References
13
Citations by year
2026: 7 · 2025: 11 · 2024: 20 · 2023: 39 · 2022: 22
FWCI
11.23
Type
journal article
Language
en
Open access
Locations
  • Influenza and Other Respiratory Viruses (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (R21AI142321‐02S1, R21AI149262, R21AI154016, R21AI142321)
  • National Institutes of Health (G20RR030956, P30EY08126, P30CA68485, UL1RR024975)
  • National Heart, Lung, and Blood Institute (R01HL146401, K23HL148638)
  • Centers for Disease Control and Prevention (75D3012110094)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
Keywords
COVID-19 pandemic, Omicron variant, Delta variant, SARS-CoV-2, disease severity, clinical outcomes, hospitalization, supplemental oxygen, mortality, variant comparison
MeSH terms
COVID-19, SARS-CoV-2, Humans

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