The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
The impact of foot ulceration and amputation on mortality in diabetic patients. I: From ulceration to death, a systematic review
Open accessAbstract
A great deal of emphasis, clinical and financial, is placed on limb salvage efforts in diabetic patients suffering from lower extremity ulceration. This is because of the impression that amputation in such patients may be a proximal cause of death. While amputation is certainly a negative clinical outcome, it is not entirely clear that it causes death. In this systematic review, we examine the available literature to attempt to understand the role that the ulceration itself may play in mortality. In brief, we searched for human studies in OVID,CINAHL and the COCHRANE CENTRAL DATABASE from 1980 to 2013, looking for articles related to ulcer or wound of the foot, in patients with diabetes or peripheral vascular disease, and death. We looked for articles with 5 years of follow‐up, or Kaplan–Meier estimates of 5‐year mortality, and excluded reviews and letters. Articles were assessed for quality and potential bias using the Newcastle–Ottawa scale. We find that while the patient populations studied varied widely in terms of demographics and comorbidities, limiting generalisability, 5‐year mortality rates after ulceration were around 40%. Risk factors for death commonly identified were increased age, male gender, peripheral vascular disease and renal disease.
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Citations
Cites
Wound healing and its impairment in the diabetic foot
Falanga, V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67700-8 · Cited by 2,639
Incidence, outcomes, and cost of foot ulcers in patients with diabetes.
Ramsey, S. D., Newton, K., Blough, D., McCulloch, D. K., Sandhu, N., Reiber, G. E., & Wagner, E. H. (1999) · Diabetes Care · doi:10.2337/diacare.22.3.382 · Cited by 1,062
Prompers, L., Schaper, N., Apelqvist, J., Edmonds, M., Jude, E., Mauricio, D., Uccioli, L., Urbancic, V., Bakker, K., Holstein, P., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-0940-0 · Cited by 1,019
Gailey, R. (2008) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2006.11.0147 · Cited by 809
Amputation and Mortality in New-Onset Diabetic Foot Ulcers Stratified by Etiology
Moulik, P. K., Mtonga, R., & Gill, G. V. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.491 · Cited by 613
Long‐term prognosis for diabetic patients with foot ulcers
APELQVIST, J., LARSSON, J., & AGARDH, C. ‐. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb01003.x · Cited by 491
Long-Term Prognosis of Diabetic Foot Patients and Their Limbs
Morbach, S., Furchert, H., Gröblinghoff, U., Hoffmeier, H., Kersten, K., Klauke, G.-T., Klemp, U., Roden, T., Icks, A., Haastert, B., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0200 · Cited by 446
An Update on the Etiology and Epidemiology of Diabetes Mellitus
ADEGHATE, E., SCHATTNER, P., & DUNN, E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.029 · Cited by 388
Apelqvist, J., Bakker, K., van Houtum, W. H., Schaper, N. C., & on behalf of the International Working Group on the Diabetic Foot (IWGDF) Editorial Board (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.848 · Cited by 341
Increased Mortality Associated with Diabetic Foot Ulcer
Boyko, E. J., Ahroni, J. H., Smith, D. G., & Davignon, D. (1996) · Diabetic Medicine · doi:10.1002/(sici)1096-9136(199611)13:11<967::aid-dia266>3.0.co;2-k · Cited by 270
Cited by
Gornik, H. L., Aronow, H. D., Goodney, P. P., Arya, S., Brewster, L. P., Byrd, L., Chandra, V., Drachman, D. E., Eaves, J. M., Ehrman, J. K., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001251 · Cited by 771
Association of diabetic foot ulcer and death in a population‐based cohort from the United Kingdom
Walsh, J. W., Hoffstad, O. J., Sullivan, M. O., & Margolis, D. J. (2016) · Diabetic Medicine · doi:10.1111/dme.13054 · Cited by 532
Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2019 update)
Bus, S. A., Lavery, L. A., Monteiro‐Soares, M., Rasmussen, A., Raspovic, A., Sacco, I. C. N., van Netten, J. J., & on behalf of the International Working Group on the Diabetic Foot (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3269 · Cited by 517
The cost of diabetic foot ulcers and amputations to the National Health Service in England
Kerr, M., Barron, E., Chadwick, P., Evans, T., Kong, W. M., Rayman, G., Sutton‐Smith, M., Todd, G., Young, B., & Jeffcoate, W. J. (2019) · Diabetic Medicine · doi:10.1111/dme.13973 · Cited by 458
Prevention of foot ulcers in the at‐risk patient with diabetes: a systematic review
van Netten, J. J., Price, P. E., Lavery, L. A., Monteiro‐Soares, M., Rasmussen, A., Jubiz, Y., Bus, S. A., & on behalf of the International Working Group on the Diabetic Foot (IWGDF) (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2701 · Cited by 422
Metadata
- Authors
- Jupiter, D. C., Thorud, J. C., Buckley, C. J., & Shibuya, N.
- Venue
- International Wound Journal
- Publisher
- Wiley
- Published
- 2015-01-20
- Volume
- 13
- Issue
- 5
- Pages
- 892-903
- ISSN
- 1742-4801 (ISSN-L)
- 1742-481X
- OpenAlex
- W2105871752
- Cited by
- 340
- References
- 38
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The impact of foot ulceration and amputation on mortality in diabetic patients. I: From ulceration to death, a systematic review. https://app.cochat.ai/papers/10.1111/iwj.12404
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- Jupiter, D. C., Thorud, J. C., Buckley, C. J., & Shibuya, N. (2016). The impact of foot ulceration and amputation on mortality in diabetic patients. I: From ulceration to death, a systematic review. International Wound Journal. https://doi.org/10.1111/iwj.12404
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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